Basic Information

Gene Symbol
-
Assembly
GCA_905163555.1
Location
LR991076.1:7572607-7581756[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0005 0.057 15.5 0.4 1 22 57 78 57 80 0.90
2 14 0.18 21 7.4 4.5 1 23 104 126 104 126 0.96
3 14 0.00042 0.048 15.7 1.1 1 23 138 160 138 160 0.96
4 14 4.4e-05 0.0051 18.8 2.4 1 23 166 188 166 188 0.99
5 14 2.7e-05 0.0031 19.5 7.6 1 23 194 216 194 216 0.97
6 14 3.5e-06 0.0004 22.3 2.3 1 23 224 246 224 246 0.98
7 14 6e-05 0.0069 18.4 3.7 1 23 252 274 252 274 0.97
8 14 8.9e-06 0.001 21.0 3.9 1 23 280 302 280 302 0.97
9 14 1.8e-06 0.00021 23.2 4.4 1 23 316 338 316 338 0.96
10 14 3.5e-06 0.0004 22.3 0.4 1 23 344 366 344 366 0.97
11 14 7.2e-05 0.0082 18.1 1.4 1 23 372 394 372 394 0.97
12 14 0.00098 0.11 14.6 5.4 1 23 400 423 400 423 0.96
13 14 2.5e-05 0.0029 19.6 6.1 1 23 429 451 429 451 0.98
14 14 1.5e-06 0.00017 23.4 1.0 1 23 457 479 457 479 0.98

Sequence Information

Coding Sequence
ATGTACCGCCGTTGTCATCTGACACTTGCAGGAACGGCGCCTATTGGAGGTCAATTTGCTTCGTTACTCATTGCGATATGCTTCGAATGTTGCGCACTTACTGCGCACTACTTGTACCAAGCTCGCTCGTCAGACGTTCGCGCAAATCCCGAACGTGTGCAGGCGTTGTACGAGTGCCTTACATGTCAGAAAAATTTCGACCAGGAGGAGAGTCTCACGAGGCATGTGTTTGCCGTCCACGCTAAACATGTACTATCCAAGGGAGAAGAAGATAAGGATAACCCTGAAGCACTCACCAAGAAGAAAATTCATACATGCGAATACTGCTGCCAATGGTTTAGACTAAAAAGTGATTTAACAAAGCATATGGAGGTACATAAGGTATCGCCCAATGAGAAAAACAATGAGCGATTCTCATGCAAAATATGTGATAAGGAATTTTTGGAGAAATCTTACTTGAAGAGACATGAGCAGGCGCATGGTGCGAAAAAGAATTATCGTTGTGAAGTGTGCGAAAAACAGTTTTTAACTAATTGGCACTTGAATAATCATATGAGATCACACACGGGTGAGAAACCACACGTCTGTCGCTTATGTTCAAAGAGATTTACACGCAAAAGTCACTTATATACTCATATGCAAACTCACAGTGACAATAGGCAATATAAATTCTCTTGTACGATTTGCAAAAAGCAATATGCCCAAAAATCTTCTTTGACTTATCATATGAGGTTGCACACAGGTGAAAAACCTTACTGCTGTGaaatctgtaataaacagtTTGCACTCAAGTCCACCTTAAAAGTCCATCAGCGGTTTCACACAGGCCAAAAACCTCACTCATGTGAAGTATGCCAGAAGAAATTCACGATGAAAAGCACTTTAACCAGGCATTTACTCACTCATGCAGAAACTTTAGACGGAGAATATACTGGAGACGAATGTTTTTGTTGCGAAATATGTGGTAAGCGTTTCCGACATAAAAGTTATTTGACTATACACATAAATGGTCACAAAGGAGTAAAACCATACTTTTGTGACATATGCAACAAACGATTTACCCAGAAAGGTGCCATAAAAGCTCATATGCTAATACACACAGGAGAGAAGTCTTACTGTTGCGAAATATGTCTCAAACAATTCGGGACAAAGGCCActttaaagaatcacatgattgTACACACTGGACAGAAACCGCATTCGTGTCAAATATGTCATAAACAATTTTCGTATAAATGTGCTTTGAACGTTCACGTGAAAGTAGTTCATCTTAGAGAGAGACCGCACACCTGCCATATGTGTAAAAGGTCATTTTCCCTGCAATCTACATTGCGGAGACATATACTGAGTCATACTGGAGAAAGACCTTTCTCTTGTCACATGTGTGGCAAGGCATTCGCAGTGAAAAACGAATTGAAGAAACACCTATTGATCCACAACAGGCACAACTAG
Protein Sequence
MYRRCHLTLAGTAPIGGQFASLLIAICFECCALTAHYLYQARSSDVRANPERVQALYECLTCQKNFDQEESLTRHVFAVHAKHVLSKGEEDKDNPEALTKKKIHTCEYCCQWFRLKSDLTKHMEVHKVSPNEKNNERFSCKICDKEFLEKSYLKRHEQAHGAKKNYRCEVCEKQFLTNWHLNNHMRSHTGEKPHVCRLCSKRFTRKSHLYTHMQTHSDNRQYKFSCTICKKQYAQKSSLTYHMRLHTGEKPYCCEICNKQFALKSTLKVHQRFHTGQKPHSCEVCQKKFTMKSTLTRHLLTHAETLDGEYTGDECFCCEICGKRFRHKSYLTIHINGHKGVKPYFCDICNKRFTQKGAIKAHMLIHTGEKSYCCEICLKQFGTKATLKNHMIVHTGQKPHSCQICHKQFSYKCALNVHVKVVHLRERPHTCHMCKRSFSLQSTLRRHILSHTGERPFSCHMCGKAFAVKNELKKHLLIHNRHN*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-