Basic Information

Gene Symbol
tfap2e
Assembly
GCA_958496325.1
Location
OY292503.1:6771994-6798461[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 4.6e-23 1.3e-18 68.2 0.1 1 44 131 174 131 176 0.98
2 8 1.5e-15 4.3e-11 43.7 0.0 14 44 174 204 174 205 0.97
3 8 5.4e-17 1.5e-12 48.4 0.1 14 46 204 236 203 247 0.95
4 8 3.2e-06 0.089 13.3 0.0 29 48 250 269 246 283 0.87
5 8 1e-12 2.8e-08 34.5 0.0 82 136 446 497 431 500 0.86
6 8 1.6e-12 4.4e-08 33.8 0.0 83 136 517 567 500 571 0.86
7 8 3.8e-05 1 9.8 0.0 85 114 575 604 569 621 0.85
8 8 1e-20 2.9e-16 60.5 0.0 83 196 621 718 602 719 0.86

Sequence Information

Coding Sequence
ATGCTGTCACACGGCGGCTTCAGCTATGGCGGCGGAGAGCGACGGGCGGACTACGGCGCGCGCGAGCAGCACGAGCTGGCCCTGCACCACGCGCTGCACTCCGCCGAGGAGGCGCCGGTACGTCTCATCACCGTCACTAgctcatcaccatcaccagcaGCCTGGCTCCTCGCTGAGCGGACTACGGCGCGCGCGAGCAGCACGAGCTGGCCCTGCACCACGCGCTGCACTCCGCCGAGGAGGCGCCgGGTTACCATACAGAAATATTACGAATCACAATGGCGATCAAGCTGCGCGCATGTTTGGGGCGTGGCGCTGATTGTTAAGGCCTATTCAATGAAAGGGCGCGACGGTCTCGGCGGCAGCGGGTCGTGCGCCCCCAACGACGTGTTCTGCTCGGTGCCGGGGCGGCTGTCGCTGCTGTCGTCCACCAGCAAGTACAAGGTCACCGTGGCGGAGGTGCAGCGCCGCCTGTCGCCGCCGGAGTGCCTCAACGCCTCGCTGCTCGGCGGAGTGCTCAGGAGCAAGTACAAGGTCACCGTGGCGGAGGTGCAGCGCCGCCTGTCGCCGCCGGAGTGCCTCAACGCCTCGCTGCTCGGCGGAGTGCTCAGGAGCAAGTACAAGGTCACCGTGGCGGAGGTGCAGCGCCGCCTGTCGCCGCCGGAGTGCCTCAACGCCTCGCTGCTCGGCGGAGTGCTCAGGAGAGCGAGCCCGCACATTGATAGGCAACCGTTTAGATCGACGGAGTCGGAGCCGGAGTGCCTCAACGCGTCGTTGCTCGGAGGAGTGCTCCGGAGAGCGATAACAGCGAACGACCTCAACTTAACACCACTCAACTTACACGACAGAACACCGCAGAAGAATGAAGAACAAATAGACAGACAcactaaaataaatgaatggacTCAGAAGTCACTGCACGGACGACACCGCCAAGATTTGTGCCAGCCCCACGTCGACAAAGATGCGTCGAACGAATGGCTAAATCGTGGAGAGTTGTTCCCAGAGACCGAGGGTTTCATGATGGCAATCCAAGACCAGGTAATTGAAACGAggaactacaaaaaatatataataagaaaCCACAACTTACCGACTGATATGTGCAGGAAGTGCAATAGTGCATCAGAAACGATTCAGCACATAACAGGAGCGTGTCGAGCTATTGTGCAGACCGATTACAAGCACCGGCACGATCAAGTCGCCAGCATCGTCCATCAGAAGCTAGCCGAGATGTACAAGCTTTTAACGCAACCCCCTATAGCATACTACAAGTACAGCCCAGAACCTGTTCTTGAAAATCAAACTCACAAGATGTATTTTGATAGAGCCATACTAACTGACCCTGAAGCAGTGCACCTAGCCCGCGACTTCGGCTACGTGTGCGAGACGGAGTTcccggcgcgcgcgctggcggaGTACCTCGCGCGGCAGTACGCGGAGCAcgacgcgcgccgccgccgcgacctACTCCAGGCCACCAAGCAGGTGCGGCCACTTACTGTCTCTCCTAGCAAAGCAGTGCACCTAGCCCGCGACTTCGGCTGCGTGTGCGACGAAGCAGTGCACCTAGCCCGCGACTTCGGCTACGTGTGCGAGACGGAGTTcccggcgcgcgcgctggcggaGTACCTCGCGCGGCAGTACGCGGAGCAcgacgcgcgccgccgccgcgacctACTCCAGGCCACCAAGCAGGTGCGGCCACTTACTATCTCTCCTAGCGAAGCAGTGCAcctagcccgcgacttcgcctgCGTGCGAGACGGAGAGTACCTCGCGCGGCAGTACGCGGAGCAcgacgcgcgccgccgccgcgacctGCTACAGGCCACCAAGCAGGTGCGGCCACTTACAATCTCTCCTAGCGAAGCAGTGCACCTAGCCCGCGACTTCGGCTGCGTGTGCGAGACGGAGAGTACCTCGCGCGGCAGTAGAGCACGACGTGACTTACTCCAGGCCACCAAGCAGGTGACGAAGGAGCTCATGGACCTGCTGAACCAGGACCGGTCGCCGCTGTGCAACACGCGGCCGCCGCACCTGCTCGAGCCGGCGATACAGAGGCACCTCACACACTTCTCGCTCATCTCGCACGGCTTCGGCGGCCCGGCCATCGTCGCCGCGCTCACTGCCATACAAAATTTCCTCAACGAGTCGCTCAAGCATTTAGACAAATTATATCCTCAAAGTGGAATGGTATCCTCGTCCATGGACAAAACAAAAATGGACCCCGACATCAAGAAGTAA
Protein Sequence
MLSHGGFSYGGGERRADYGAREQHELALHHALHSAEEAPVRLITVTSSSPSPAAWLLAERTTARASSTSWPCTTRCTPPRRRRVTIQKYYESQWRSSCAHVWGVALIVKAYSMKGRDGLGGSGSCAPNDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRSKYKVTVAEVQRRLSPPECLNASLLGGVLRSKYKVTVAEVQRRLSPPECLNASLLGGVLRRASPHIDRQPFRSTESEPECLNASLLGGVLRRAITANDLNLTPLNLHDRTPQKNEEQIDRHTKINEWTQKSLHGRHRQDLCQPHVDKDASNEWLNRGELFPETEGFMMAIQDQVIETRNYKKYIIRNHNLPTDMCRKCNSASETIQHITGACRAIVQTDYKHRHDQVASIVHQKLAEMYKLLTQPPIAYYKYSPEPVLENQTHKMYFDRAILTDPEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVRPLTVSPSKAVHLARDFGCVCDEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVRPLTISPSEAVHLARDFACVRDGEYLARQYAEHDARRRRDLLQATKQVRPLTISPSEAVHLARDFGCVCETESTSRGSRARRDLLQATKQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQNFLNESLKHLDKLYPQSGMVSSSMDKTKMDPDIKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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