Basic Information

Gene Symbol
-
Assembly
GCA_907165295.1
Location
OU015689.1:3811057-3813867[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.012 1.2 9.9 0.8 2 22 121 140 120 140 0.86
2 14 0.015 1.5 9.6 0.8 5 20 150 165 146 168 0.90
3 14 0.12 11 6.8 3.7 1 23 174 197 174 197 0.92
4 14 8.1e-06 0.00078 19.9 0.5 1 23 203 225 203 225 0.98
5 14 5e-05 0.0048 17.4 1.9 1 23 375 397 375 397 0.97
6 14 0.0032 0.3 11.7 0.3 2 21 407 426 406 427 0.93
7 14 0.00028 0.027 15.0 2.6 1 20 449 468 449 471 0.92
8 14 0.013 1.3 9.8 0.7 1 23 476 499 476 499 0.95
9 14 1.2e-06 0.00011 22.5 0.3 1 23 505 527 505 527 0.98
10 14 0.002 0.19 12.4 6.3 1 23 534 556 534 556 0.98
11 14 0.00034 0.032 14.8 0.4 3 23 564 584 562 584 0.97
12 14 0.00038 0.037 14.6 0.2 1 23 590 613 590 613 0.96
13 14 0.21 21 6.0 0.1 1 23 627 649 627 649 0.93
14 14 0.0012 0.12 13.0 0.0 2 23 914 935 913 935 0.96

Sequence Information

Coding Sequence
ATGGAAGCCCATGAAAATGAACAATACGTTACATTTCCCCTCTCAGGGGTGCACGATGGTATGCAAGATAATATTATATCACACGAAGAGATATGTGAACCTGTTGACGAGTGTGTCCTCCAAGAGGGACTCTCAGAGGTATCCGTTACAGATGTTAATTCTGGTATTACAGAGGCACAAGCTGCTGTTGAGATTTTGGCAGAACATTCCGACGAGGAAGATGGGAAATGTATAGTATATCCCATATATATTAAACAAGAAGAACAGCAACAATACACATCAGGAGACGATGAATCTATGGCTGTGGAAGCACTCAGACAACTGGGAGGGATGTATCCTTGCTTCGAAAACAAGAAAGTGTCTTGTCCGAATTGTGGAAACTTTTTTACACAATCGGAGATGACAAAGCATCATAACACTTGCAGCGCTATTAAATTATCTTGTATTACATGCGGGGAGAGATTTGAACGGAAAATAGATTTAACCAATCATATGGTTTGCCATCAAGTTGATCGTCCGCACGCTTGTAGAACTTGCGGTAATTTGTTTCGTTCCAAAAGCAATTTAAGATGTCATATATTGCAAGTGCATCAGGTAGAGAGACCTCACAAATGCGCCATATGCGGAGCAGACTTTCAGAGGCCTTCTAGTCTATCCAATCATATGAAGATTCATACATACGTTGCTGGACGTGCTATCATGCAGTCGCAGGGTAATAATGCATCGCAATCAGAGGAGACATTTAGAAAGTGGCCTGAAAATGTGTCGGAGTCTCAAAATAATCAAATTCCATCTTCCTCTATACAAGCTGTACAAAATTATGATACAGTTCACTGGACGGTTCCGTCATACGATTTTCAGAATGAACAATCAACAGTTAATGCAATATCTAATTCTGAAGAAAAAATAGACACTTTACATGAATTTACTGTAATGCCAAACGGAGAAGTAACGCAATTCGAGTATACGCAACAGAATAACATAGATAATCAAGTCAATCAGCAATACAACATCTCGTTAAACACGTTCAACAATGCTGATACAATTGTGAAAGTTGAAACTTTATACAATAATGAGAATAGGAAAAATTACGTAGAAGTTGAAACGAATAGTACAAAGCAACATACCTGTAGACATTGTGGAATTAGTTTTTCACGTGCAACAGCTCTCGTGTCTCATGAGAAAATTCATGCATCAAAGAATTGGAACATGCCAATCGAATGCGAGTATTGTGATAAGCAATTTCAAGATGGCAATCATTTAGCAACACATCAAACCACATGTGCAAAAAAGCTGATGCAAAATAATATAGAGCAAGGTACACCTAATAATAAATGGGGTAAACATGCCTGTTCTGAATGCGGTAAAAAATTTACTACTAAGCAAAAAATGTTCAGACACCAATGGATTCACAGGAAGAAAACCCATTCCTGTGAAGTCTGTGGATCTCAATTTGAAAAACAAAATCAATTGGACGAGCATAGACTCTCAGCGCATCCTGGGGATTCTCCATTTACTTGTACAGAATGTGGTAAAAGTTTTGTATCTCGTCAAGGACTCTGGGAACATGGTAGAACTCATGCTGGAAGTCCGGCGCATTTTCATTGTGATACATGTTCCAAAACATTTTCATCTAGACAGGGGTATTTGATACATCATAGAACTCATACTGGAGAGAGACCATATGGCTGTAAATTTTGTTGGAAAGCATTTAGGGATGGCGGTACATTGAGGAAACACGAACGTATTCACACAGGAGAAAGACCTCATGTGTGTCCTCTATGTTCAAGGGCATTTAATCAAAAAGTTGTTCTCAGAGAGCACGTTCGATGGGTCCATGCAGCAGGGAAAAATGAAACAGAAGTAACAGGTCCACCATTCCCTTGTCCTATATGCGGTGCACTAAATCAGGATAGAGACGAATTATGTGCACATATTGTTAAACACTCGGATCAGATGATAGCAGAAGCAAAGGCTAAAACGAATAATAATACGCCAAAAACCAAGCCAGTTAAGAAGAAATCAAAATCATCTGCGAGCACAAGCTTACACGGCAAGCACGGGAGTGGGGCTCGCATAATTTCCAAAACGGAAGAGGATGAAGCACTTTTATCTATTACGGAAACGGATAAATCAGATGACCAACAAATTTTAAATGAAAAACAGAACAATACTTTTCTTGTAGTTACGGCCGAAAAGCGTAACGATAACTATATCGCAATATCTGAACTGAAGTCTGAAGATGTGCAGCTATTAGTTGAGGAGAAACAAGACGAAGATATGCATATTTCGCAAAGTAATCACAGCCATGCAGAATCTTTAAATATGATCGCTATGGATAAGCAGAATAATACAAGCCACATAGTAACTACAGAACGAGAAAGAAGTGCACTTCACTCTACAGCCAGTCATAATGAAATAACGACAATGCGTTGTTTAATACAATCATCGAAGCAAAGTAACACTTTACATTTGATATCAAAGCAAAGTGAATCATTGCCTGTTTTAGCATTACCGAACCCACAGAGCCATGAGAATTTTTCAAGTCAAATTGCACAAATAAATGATAGAGATTTACCTATGCATGTGGTGACTCATCATTCAACTAGAGAAGATCGAGATATAAAGGACTGCAATGATGTTGGGCATGATACATTAATTGAAGAGGAAGCATCCCAAACGGCTGTAATACAAGTTGTACAGTATCATCAACAAGAAAGTGATGATGAAGAGGAATTAGTCTGTGGTATTTGTGGAGAAGATTTTAATGATAAAAATGTGTTGATGGAGCATGTTAAAATACATATATAA
Protein Sequence
MEAHENEQYVTFPLSGVHDGMQDNIISHEEICEPVDECVLQEGLSEVSVTDVNSGITEAQAAVEILAEHSDEEDGKCIVYPIYIKQEEQQQYTSGDDESMAVEALRQLGGMYPCFENKKVSCPNCGNFFTQSEMTKHHNTCSAIKLSCITCGERFERKIDLTNHMVCHQVDRPHACRTCGNLFRSKSNLRCHILQVHQVERPHKCAICGADFQRPSSLSNHMKIHTYVAGRAIMQSQGNNASQSEETFRKWPENVSESQNNQIPSSSIQAVQNYDTVHWTVPSYDFQNEQSTVNAISNSEEKIDTLHEFTVMPNGEVTQFEYTQQNNIDNQVNQQYNISLNTFNNADTIVKVETLYNNENRKNYVEVETNSTKQHTCRHCGISFSRATALVSHEKIHASKNWNMPIECEYCDKQFQDGNHLATHQTTCAKKLMQNNIEQGTPNNKWGKHACSECGKKFTTKQKMFRHQWIHRKKTHSCEVCGSQFEKQNQLDEHRLSAHPGDSPFTCTECGKSFVSRQGLWEHGRTHAGSPAHFHCDTCSKTFSSRQGYLIHHRTHTGERPYGCKFCWKAFRDGGTLRKHERIHTGERPHVCPLCSRAFNQKVVLREHVRWVHAAGKNETEVTGPPFPCPICGALNQDRDELCAHIVKHSDQMIAEAKAKTNNNTPKTKPVKKKSKSSASTSLHGKHGSGARIISKTEEDEALLSITETDKSDDQQILNEKQNNTFLVVTAEKRNDNYIAISELKSEDVQLLVEEKQDEDMHISQSNHSHAESLNMIAMDKQNNTSHIVTTERERSALHSTASHNEITTMRCLIQSSKQSNTLHLISKQSESLPVLALPNPQSHENFSSQIAQINDRDLPMHVVTHHSTREDRDIKDCNDVGHDTLIEEEASQTAVIQVVQYHQQESDDEEELVCGICGEDFNDKNVLMEHVKIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2