Basic Information

Gene Symbol
-
Assembly
GCA_963576755.1
Location
OY755080.1:4030787-4033950[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0029 0.23 12.7 0.7 1 21 64 84 64 85 0.96
2 17 2.4 1.9e+02 3.5 0.3 2 23 113 134 113 134 0.94
3 17 0.0031 0.25 12.6 0.2 2 23 157 178 156 178 0.97
4 17 0.00041 0.032 15.4 0.1 1 23 182 204 182 204 0.97
5 17 0.079 6.3 8.1 0.1 1 23 209 232 209 232 0.80
6 17 0.0004 0.031 15.4 1.1 1 23 238 261 238 261 0.97
7 17 0.0017 0.13 13.4 1.1 1 23 268 291 268 291 0.97
8 17 1.1e-05 0.00087 20.3 0.8 3 23 300 320 298 320 0.97
9 17 7.8e-07 6.2e-05 23.9 2.3 1 23 326 348 326 348 0.98
10 17 0.0091 0.72 11.1 0.2 1 23 425 448 425 448 0.95
11 17 0.12 9.6 7.6 0.2 2 23 475 496 474 496 0.96
12 17 0.022 1.8 9.9 0.8 1 23 518 540 518 540 0.98
13 17 2e-05 0.0016 19.4 1.0 1 23 544 566 544 566 0.98
14 17 0.73 57 5.1 0.2 1 23 571 594 571 594 0.88
15 17 0.0083 0.65 11.2 0.6 1 23 600 623 600 623 0.90
16 17 0.00064 0.051 14.7 0.6 1 23 630 653 630 653 0.97
17 17 4.8e-05 0.0038 18.3 1.9 1 23 660 682 660 682 0.96

Sequence Information

Coding Sequence
ATGTATTCTAGATATTACGTAGTGAgaCAACGCTGCGAATCAAACGAAGGTGATTACGAATTAGAAAAGTTACCCAAGCCGAAGTATATTAGAAGTGCTAGAGCCGAAGCCAGGATTATCACCAAGAGTAATGCTTCAGCCATCTTAGAATGCTGGTCACTCCTGCCTTTTAGATGGAAGAAGAACAGATTCAAATGTGCCTACTGCGAAGAGAACTTTACTGAATGTACAGAACTTAGAGACCATGTTCGCATCTGCTCCACAAGTCACAGTATCAAAGATATATACAGCAAATTCAAAGAAATGCCTTTAATCAACGTTGATATTACAAACGCAGTCTGTTCCTTATGTTCTTTGCCTCTTACAAATGCCACTCAAATTAGAGACCACGTAATTCATCACGGTCTAGATTTCAACCCCTATCACCCTGACGGAATACTACCATTTTGTCTCGACAAACAGTCTTGGCAATGTGTAATATGCCCGGAAAAATTCAACAACTTCCTAAAACTTTATGAGCATATGAATGTTCATTACCAACACTATATTTGCGCGACTTGTGGTAAAGGATTCATGACTGCTCCCAGATTGAGGAAACATTTAGAGGTTCATGTATCTGGATCATTTCCGTGCAATAAATGCGGCAGGATCTTTATTATGAGAGCAGCAAGGGATTCGCACAAGGCTTCTGTTCATCCTAAAGCTCCTCGATACGAATGCCCCCACTGCAATATCAGATTTGACAATTATTACGAAAGAATTGATCACATGAAAAACGCACACAGCGAGAGAGAAGTGTCCTATAACTGTGCCCATTGCGAGATGTCTTTTAAAACTAGTGGGAAACGCGCGATTCACGTCCGGACAGTCCATTTTCCACCACAATTGAACTACGGTTGCAGTTATTGCGAGTGGCAATTTAGGACCAACTATGAATTGAAAAGGCATATGGTACGACACACAGGGGAGAAGAATTTTCATTGCTCAGTATGCGGGAAGTCTTTTCCGAGGAATAGAGCGTTGACTTCGCATCTAAAAACTCATCAAGATATGAATGGTTCCGCTATCGAAGCGGTGGGCAATCTAGGAGTTAGACGAATTAGGAAGTTGAAAGAAAACGTAAGCGATCGCCAAATGCGCAGACGACGACGCGCGAACAACCAGCTCCCCGAAGAATCTGAGAAACGAATCTCCAAAACCATGATGCGTCGAAACGCCATGATCCTTCTAGAATGTTCCACAGCGTGGGCCTTTAGATGGTTCCATAGCGCTTTTTATTGTTCTTACTGCGAAGCTAAATTTGTTGATGTACCTCTTCTACGTTCACATGTTAAAGCTTATCACCTAGACGAGTTACCAACTGAAAGAATTTTCTcgaagttaaaagaaaataacatgGTCAAAGTAGATGTAGCTGAACTTAGTTGTAGGTTGTGTAGCAGGATTTTAAATAGCATTGACTCTTTAAAAGATCACCTGCTGATTCATGGAAAGACTTTGAACGTAGAGTACAGTGATGGAGTCCTCCCATTCAAGTTAGATGAAGAAGTATTTACTTGCCAGCTTTGCTTCGCCCAATTCGTAACTTTCGCCAAAATTAATGAGCATATGAATACACACTTTCAAAATTACATCTGCGATTCTTGCGGGAAAGCTTTTGTCTCTAAATCAAGATTTAGAAAACATGTCCAGTCTCATGAAAAGGGTAATTTCCCATGCGGGGAGTGCGGGGAAGTTTTAGAAACACGAGCGTCTCGGATGTGTCATATAATGCGGATTCATAGAAAAGGCGTCCGCTATGCTTGCCCAAGATGTCCTGAAGTCTTCACGACATACCATACAAGGGCGAAGCATTTAGTAGAAACTCACGCTCAACAGAGAAAAGAGTACTATTGTAACGCTTGCGACAAAACCTTTGAAACAAGCTCCAAAAGAGCAGGACATATTCGCGTGACCCATGCTAATGTAGAAAAACGACACTTCTGCCCAAACTGTCCCTCGATATTTGTTAGCAAATCGAAGCTGCTGCGGCATCTAAGAACACATAGAGTAAAATACGACTGA
Protein Sequence
MYSRYYVVRQRCESNEGDYELEKLPKPKYIRSARAEARIITKSNASAILECWSLLPFRWKKNRFKCAYCEENFTECTELRDHVRICSTSHSIKDIYSKFKEMPLINVDITNAVCSLCSLPLTNATQIRDHVIHHGLDFNPYHPDGILPFCLDKQSWQCVICPEKFNNFLKLYEHMNVHYQHYICATCGKGFMTAPRLRKHLEVHVSGSFPCNKCGRIFIMRAARDSHKASVHPKAPRYECPHCNIRFDNYYERIDHMKNAHSEREVSYNCAHCEMSFKTSGKRAIHVRTVHFPPQLNYGCSYCEWQFRTNYELKRHMVRHTGEKNFHCSVCGKSFPRNRALTSHLKTHQDMNGSAIEAVGNLGVRRIRKLKENVSDRQMRRRRRANNQLPEESEKRISKTMMRRNAMILLECSTAWAFRWFHSAFYCSYCEAKFVDVPLLRSHVKAYHLDELPTERIFSKLKENNMVKVDVAELSCRLCSRILNSIDSLKDHLLIHGKTLNVEYSDGVLPFKLDEEVFTCQLCFAQFVTFAKINEHMNTHFQNYICDSCGKAFVSKSRFRKHVQSHEKGNFPCGECGEVLETRASRMCHIMRIHRKGVRYACPRCPEVFTTYHTRAKHLVETHAQQRKEYYCNACDKTFETSSKRAGHIRVTHANVEKRHFCPNCPSIFVSKSKLLRHLRTHRVKYD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00274620;
90% Identity
iTF_00746027;
80% Identity
-