Basic Information

Gene Symbol
-
Assembly
GCA_001412225.1
Location
NW:130183-134708[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 0.00031 0.021 14.7 6.0 1 23 168 190 168 190 0.98
2 21 0.0015 0.1 12.5 0.3 1 23 210 232 210 232 0.98
3 21 7e-06 0.00048 19.8 2.5 1 23 239 262 239 262 0.97
4 21 6.7e-07 4.5e-05 23.1 0.3 1 23 268 290 268 290 0.98
5 21 2.8e-05 0.0019 17.9 1.9 1 23 296 318 296 318 0.93
6 21 4.5e-05 0.0031 17.3 0.7 3 23 326 346 324 346 0.96
7 21 1.4e-05 0.00096 18.9 0.8 1 23 352 374 352 374 0.98
8 21 0.0001 0.0068 16.2 0.8 1 23 380 402 380 402 0.99
9 21 2.4e-05 0.0016 18.2 2.1 1 23 408 430 408 430 0.98
10 21 1.6e-06 0.00011 21.9 0.8 1 23 436 458 436 458 0.98
11 21 0.00033 0.022 14.6 2.5 1 23 649 671 649 671 0.98
12 21 0.098 6.7 6.8 0.2 1 23 699 721 699 721 0.93
13 21 3e-06 0.0002 21.0 5.1 1 23 728 750 728 750 0.98
14 21 8.6e-06 0.00059 19.6 3.4 1 23 756 778 756 778 0.98
15 21 5.5e-07 3.7e-05 23.3 1.8 1 23 784 806 784 806 0.98
16 21 3.2e-05 0.0022 17.8 0.7 1 23 812 834 812 834 0.94
17 21 2e-05 0.0014 18.4 0.3 3 23 842 862 840 862 0.96
18 21 1.9e-06 0.00013 21.6 2.9 1 23 868 890 868 890 0.98
19 21 9.7e-05 0.0066 16.2 0.8 1 23 896 918 896 918 0.99
20 21 2.3e-06 0.00015 21.4 1.0 1 23 924 946 924 946 0.98
21 21 6.6e-07 4.5e-05 23.1 1.2 1 23 952 974 952 974 0.98

Sequence Information

Coding Sequence
ATGGAAGAAGAAAGTATTCCCATGGATATGGATATTTGTCGTTTGTGTATGACAGAAGTGGGTTCCTTTAAATCTGCATTTGATGCTGAAGAAAACACAGGATTAGAAGTTCTTCTTGCAGATATGATTATGGCTTTCACTTCTGTCcaaatGACAATAGGAGATGGTCTACCTGACAAAATATGTGATGTTTGCTATCAAAAAGTACCAgacatgtatatatttaaaaagcaaTGTGAGGAAGCTGATAGAAAACTTAGGATGACTTTAAAGAAATTTCCTTTCAATTTGAATGAGGATGATATGACCCCCATAGAATTAGACAATtcagaaaatgttattattaaacctGACATTTccaatgttaaaattgaagttgTTGATCAACAATCAGATGAAGATGTTGTATGTAATGTAAAAGTGGAGAATGTGGATGAGCATGTCAACTATAATATACAAGATCAAACAATGCAAATCTGCAATGCAGaaaaatccaaattatttgaatgtgATCAGTGCAGCAAATGTTTCAAAAGGGAAGACTTTTTTGTGCGACATAAAAAAACCcatgaaataacatttatccaaataaaagaagaaatcaaAGATATATCACAGGAGCAAGAGTTCAAATGTGCAACATGTAATATGGAATTTGATAGTAATGAGACTTATAATGAACATTTAGAAATTCATAGAGAAAGAGGAGAGCTGTTCCGCTGTCAAATTTGCAGTaaacaatttgcaaaaaattTCCAACTTACAAGGCATATGAAACAAATACATTCTAGTTTAAAACCAtacatatgtaatatttgCTCAAAAGCTTTTAATCAGATTTCAACATTAACTGATCACATGCGTATACACAATGGGGAGAAACCATTTTTGTGTTCAACTTGTGGTAAAAGTTTTAATCATTTAGGCAATTTGAAGCAGCATGCTGTTAGGCATAGTGGAGTAAAGGCGCATTTGTGTAACCTTTGTGGCAATGGTTTTGCTAGTAAAGGAGAATTAAGTGTGCATATGCGAAAACATAcaggTGTACGTCCGTTCGTATGCACGGTTTGTAACAGCGGTTTCACGACTTCCAGCTATCTGGCCAAGCATAAGAGGATACACTCGGGCGAAAAGCCGTACGAATGCGACGTATGTAAGATGAAGTTTTCTCGATCAGGAATTCTTGCGCGTCACAAAAGGACGCATACTGGTGAAAAGCCGTATGTTTGTAAATTCTGTTCAAAAGCTTTTGCTCAGTCGAACGATCTAAGCTCACACCACAGAATACATACAGGCGAAAAACCCTATATCTGCGATCTCTGTGGTCAAGCCTTCCGACAGAGCTCAACACTTAAAACCCATAAAAAGGTTCATATGGACAAAAATAGCCGACAAGATGCAGATGTAAATGTCGCGATATCGAATATACAgcatgttattaataaaatcaagaacgaaaataatatggaaGAGAATAGTTTGCGGAATATTTGTCGTGTTTGCATGACGGAGAAGGGTATTTTTCAATCAGTTTTTGTTTCAGAGGAGAGAACAGGCTTGAAAATTCATCTTGCTGAAATGGTTATGGCTTATACTTCTGTCCAGATAACGTTAGGAGATGGGTTACCAGAAGAGATTTGCTCAGAATGTGCAGAGAGAATACCAGACTTGTACTTATTCAAGATGAAATGCGAAGAGACAGACAGAAATCTGAGATTACGATTGGGGAAGAACCCTTTTAAACTTATAGAACATGAGGAAGaagatttacataattttgatttagaaGATAATGACTCTGAGGATGTCATTATTAAACCAGATATTTGTGatgttaaaatagaaaatttggaAGATATACCAATTGAAAAGTTCGTAGAGTACACAGAACCTAATGATATTTCAACTGATTTGGATAATAGTGGTGATATGCAAGGAAAGTTATTTGAGTGTGGTGAatgcaataaatgttttacCAAAGAGGATATACTTGTTAGGCATAAAAGGTCTCATGAAGCAACagtaatacaaattgaagaagaagatgCTGATGACATTGATGATTTGACGGATCCACtaacaacaaaacaagaatATAAATGTTCAACATGTAATATGGAATTCGATAATGGTATAACTTATGATGAACATTTGGAAATACATAAGGAAAGTGGAGATATTTTCTCATGtggaatttgtaataaaaagtttacGAAAAATTTTCATCTCAACAGACATATGAAGTTGCATGCTGTTGTTAAACCCCATACATGTAAAGTATGCAATAAGGGATACACAAGAGCTGAGCAGCTGAGTCATCATATGAATATTCATACAGGTATCAAACCACATGTTTGTAATGTGTGTTCTAAAgGTTTCAACcagatttcaaatttaaaagatCATATGAGAACCCACAATGGAGAAAAACCATTTTTGTGTTCCACTTGTGGCAAAGGTTTCAATCAATTGGGCAACTTGCGACAACATACTGTCAGGCATAGTGGTATCAAGGCTCATCTATGTAATATATGTGGTAACGGCTTTGCTAGCAAAGGTGAATTATCCGCGCATATTAGAAAACATACAGGTGCACGTCCGTTTGTGTGCTCTATCTGTAATCACGGTTTCACAACATCAAGTTCTCTCACGAAACATAAGCGAATTCACTCGGGCGAAAAACCGTATGAGTGCGAGGTGTGCAAGATGAAGTTTTCGCGTTCGGGAATTCTCGCGCGTCATAAAAGGACGCACACCGGCGAAAAACCCTACGTGTGCAAATTCTGTTCAAAAGCGTTCTCACAGTCAAACGACCTTAGTTCCCATCTCAGAATTCATACAGGCGAGAAGCCCTACATATGTGATCAGTGCGGACAGGCATTTCGTCAGAGTTCCACCCTCAAaaagcacaaaaaaatacacagcGATAAGAACAATATGATCGATTCAGGCGTTGTTATCGGAATGGTGGTACCCTTCCTGAATAACATTTAG
Protein Sequence
MEEESIPMDMDICRLCMTEVGSFKSAFDAEENTGLEVLLADMIMAFTSVQMTIGDGLPDKICDVCYQKVPDMYIFKKQCEEADRKLRMTLKKFPFNLNEDDMTPIELDNSENVIIKPDISNVKIEVVDQQSDEDVVCNVKVENVDEHVNYNIQDQTMQICNAEKSKLFECDQCSKCFKREDFFVRHKKTHEITFIQIKEEIKDISQEQEFKCATCNMEFDSNETYNEHLEIHRERGELFRCQICSKQFAKNFQLTRHMKQIHSSLKPYICNICSKAFNQISTLTDHMRIHNGEKPFLCSTCGKSFNHLGNLKQHAVRHSGVKAHLCNLCGNGFASKGELSVHMRKHTGVRPFVCTVCNSGFTTSSYLAKHKRIHSGEKPYECDVCKMKFSRSGILARHKRTHTGEKPYVCKFCSKAFAQSNDLSSHHRIHTGEKPYICDLCGQAFRQSSTLKTHKKVHMDKNSRQDADVNVAISNIQHVINKIKNENNMEENSLRNICRVCMTEKGIFQSVFVSEERTGLKIHLAEMVMAYTSVQITLGDGLPEEICSECAERIPDLYLFKMKCEETDRNLRLRLGKNPFKLIEHEEEDLHNFDLEDNDSEDVIIKPDICDVKIENLEDIPIEKFVEYTEPNDISTDLDNSGDMQGKLFECGECNKCFTKEDILVRHKRSHEATVIQIEEEDADDIDDLTDPLTTKQEYKCSTCNMEFDNGITYDEHLEIHKESGDIFSCGICNKKFTKNFHLNRHMKLHAVVKPHTCKVCNKGYTRAEQLSHHMNIHTGIKPHVCNVCSKGFNQISNLKDHMRTHNGEKPFLCSTCGKGFNQLGNLRQHTVRHSGIKAHLCNICGNGFASKGELSAHIRKHTGARPFVCSICNHGFTTSSSLTKHKRIHSGEKPYECEVCKMKFSRSGILARHKRTHTGEKPYVCKFCSKAFSQSNDLSSHLRIHTGEKPYICDQCGQAFRQSSTLKKHKKIHSDKNNMIDSGVVIGMVVPFLNNI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-