Basic Information

Gene Symbol
-
Assembly
GCA_951802705.1
Location
OX637867.1:9178287-9179435[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 4.8e-06 0.0004 20.9 2.8 2 23 151 172 150 172 0.97
2 8 0.024 2 9.2 0.4 3 23 178 198 177 198 0.97
3 8 9.3e-06 0.00078 19.9 0.5 3 23 206 226 204 226 0.97
4 8 3.3e-07 2.8e-05 24.5 0.4 3 23 234 254 233 254 0.98
5 8 8.2 6.9e+02 1.2 4.4 1 23 263 285 263 286 0.79
6 8 0.15 12 6.7 1.4 3 23 293 312 292 312 0.94
7 8 1.6e-06 0.00013 22.3 2.2 3 23 320 340 319 340 0.97
8 8 2.1e-06 0.00017 22.0 2.3 1 23 346 368 346 368 0.98

Sequence Information

Coding Sequence
ATGAGCACTTGGATGCTACGGAGAGCGAGGAAATTGCGTCGATCGTCTTTGATGAAAATTCCAACGAACGAATATCcggtcgatgaaaaaacattcgagATCGTTGATTCTATCATAAGAGCGGAAGTTGAGGCAGAAAAACGTGAATCGAGATTGTCGAAGCGACAGAGGATGCCAACAACACGATATCATTGCGAATCGAAAGAATCATTACTCCTGCACAGAACCGAGCGACTTCATCAAGTACGACAGAATAATCGTGATAATATCTTATCAGCGTATAATTGTCCTTATAGCgatgaaaaatgtgtaaaaagtACGTCGTTCTTTAAAAATCAGACAGAGCATTGCAGAAAGAGCAAAAAGGTGATAAATACTGGTCCTGATGATCAGGAACAGTTCGATTCGTATCGAACCGAAAGGAACAAACAGTCCCAGTCGGGGTCAGTCGAGTGTGATATTTGTCACAAAAgtttcaagaaaaagaaatacgttCGTGTTCACATGCGCCTTCATGGATCTCCACGAATTTGCGACGTTTGCGGTGCGATTCTGGCCTCAGAGTTTTGTCTCGAGCAGCACAAGAGACGTCACAACTCGGATTACTCGACATTTTGTGAAATTTGTCAAAAGGGCTTCTATAACAAAGCAACGTTGACAATTCATATGGCGAAGCATACGAAAGAGAAGAATGTAGCTTGCGAGATTTGCAAAAAAGCATTCGCCAATCGCGTCTATCTGAGAAGTCATATGAGAACGCATCTTGATCcgaaaacgcgaaagaaatttaaatGCGAAATGTGCAATTTCGAGACATTCTGGAGCTACTGCTACAAGGAACATCGAGAAACTCATACGGGCGAGGGTCGAGTGGCGTGCCCATTATGCGGCAAATACATACGTCGACATTACATGAAGACCCATGCGAAAATGCACGCTGGTGATAAAACGGAGATGTGCGAATTCTGCGGCAAAGGTTTCGTCTCGAGAAAATACTTAAAGAAGCATAGGCGAACTCATACGGGCGAGAAACCTTACTCGTGTTTCGTTTGCGACACAAATTTCACTCAACGCTCCAGTCTCACGAAACATCTCAAGTTGCACGAAAGCAACGAGCTCGAAGGCTCCGCGAACGTCGCGCCGAGCTGA
Protein Sequence
MSTWMLRRARKLRRSSLMKIPTNEYPVDEKTFEIVDSIIRAEVEAEKRESRLSKRQRMPTTRYHCESKESLLLHRTERLHQVRQNNRDNILSAYNCPYSDEKCVKSTSFFKNQTEHCRKSKKVINTGPDDQEQFDSYRTERNKQSQSGSVECDICHKSFKKKKYVRVHMRLHGSPRICDVCGAILASEFCLEQHKRRHNSDYSTFCEICQKGFYNKATLTIHMAKHTKEKNVACEICKKAFANRVYLRSHMRTHLDPKTRKKFKCEMCNFETFWSYCYKEHRETHTGEGRVACPLCGKYIRRHYMKTHAKMHAGDKTEMCEFCGKGFVSRKYLKKHRRTHTGEKPYSCFVCDTNFTQRSSLTKHLKLHESNELEGSANVAPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01057134;
90% Identity
-
80% Identity
-