Basic Information

Insect: Nephrotoma appendiculata
Gene Symbol: ZEB2
Assembly: GCA_947310385.1
Location: OX371223.1:357527343-357540096[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 22 0.075 17 8.2 0.5 1 23 440 463 440 463 0.93

2 22 0.051 11 8.7 1.7 1 23 471 494 471 494 0.97

3 22 7.2e-05 0.016 17.7 6.7 1 23 501 523 501 523 0.98

4 22 1.6e-05 0.0035 19.8 1.0 1 23 529 551 529 551 0.99

5 22 0.00033 0.072 15.6 0.8 1 23 557 580 557 580 0.96

6 22 0.0006 0.13 14.8 0.7 1 20 585 604 585 607 0.94

7 22 0.17 39 7.1 0.4 2 14 615 627 614 628 0.89

8 22 0.13 28 7.5 0.4 1 22 945 966 945 968 0.89

9 22 0.02 4.4 10.0 1.8 1 23 976 999 976 999 0.97

10 22 0.0055 1.2 11.8 5.0 1 23 1006 1028 1006 1028 0.98

11 22 2.7e-05 0.006 19.1 0.8 1 23 1034 1056 1034 1056 0.98

12 22 0.00024 0.054 16.0 0.5 1 23 1062 1085 1062 1085 0.96

13 22 0.0006 0.13 14.8 0.7 1 20 1090 1109 1090 1112 0.94

14 22 0.17 39 7.1 0.4 2 14 1120 1132 1119 1133 0.89

15 22 0.12 27 7.6 2.3 1 23 1336 1358 1336 1359 0.94

16 22 0.015 3.4 10.4 2.6 1 23 1367 1390 1367 1390 0.96

17 22 1.7e-07 3.8e-05 26.0 1.6 1 23 1399 1421 1399 1421 0.98

18 22 0.053 12 8.7 1.9 1 23 1427 1449 1427 1449 0.98

19 22 0.59 1.3e+02 5.4 1.9 1 23 1455 1478 1455 1478 0.94

20 22 1.2e-05 0.0026 20.2 4.0 1 23 1483 1505 1483 1505 0.97

21 22 0.00034 0.076 15.6 6.4 2 23 1512 1533 1511 1533 0.97

22 22 0.014 3.1 10.5 6.7 1 23 1538 1561 1538 1561 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	22	0.075	17	8.2	0.5	1	23	440	463	440	463	0.93
2	22	0.051	11	8.7	1.7	1	23	471	494	471	494	0.97
3	22	7.2e-05	0.016	17.7	6.7	1	23	501	523	501	523	0.98
4	22	1.6e-05	0.0035	19.8	1.0	1	23	529	551	529	551	0.99
5	22	0.00033	0.072	15.6	0.8	1	23	557	580	557	580	0.96
6	22	0.0006	0.13	14.8	0.7	1	20	585	604	585	607	0.94
7	22	0.17	39	7.1	0.4	2	14	615	627	614	628	0.89
8	22	0.13	28	7.5	0.4	1	22	945	966	945	968	0.89
9	22	0.02	4.4	10.0	1.8	1	23	976	999	976	999	0.97
10	22	0.0055	1.2	11.8	5.0	1	23	1006	1028	1006	1028	0.98
11	22	2.7e-05	0.006	19.1	0.8	1	23	1034	1056	1034	1056	0.98
12	22	0.00024	0.054	16.0	0.5	1	23	1062	1085	1062	1085	0.96
13	22	0.0006	0.13	14.8	0.7	1	20	1090	1109	1090	1112	0.94
14	22	0.17	39	7.1	0.4	2	14	1120	1132	1119	1133	0.89
15	22	0.12	27	7.6	2.3	1	23	1336	1358	1336	1359	0.94
16	22	0.015	3.4	10.4	2.6	1	23	1367	1390	1367	1390	0.96
17	22	1.7e-07	3.8e-05	26.0	1.6	1	23	1399	1421	1399	1421	0.98
18	22	0.053	12	8.7	1.9	1	23	1427	1449	1427	1449	0.98
19	22	0.59	1.3e+02	5.4	1.9	1	23	1455	1478	1455	1478	0.94
20	22	1.2e-05	0.0026	20.2	4.0	1	23	1483	1505	1483	1505	0.97
21	22	0.00034	0.076	15.6	6.4	2	23	1512	1533	1511	1533	0.97
22	22	0.014	3.1	10.5	6.7	1	23	1538	1561	1538	1561	0.98

Sequence Information

Coding Sequence: ATGGATTTAATTTGCAGAACGTGTTTGGCATATAATGACGAATTGGAACCCCTATATGCTAAAAAACTAGTGGATACAGACTATGAGGATATAACTACAATGATATTTCTTTGTACTGGATTAGAGATTTCCAAAGGTGATCAACTATCTGATACAATTTGTACGCAATGCATCGATTCGATTATAGCAGCATTTAAATATCGTAAAAAGGTTTGGAAATCAAATAATATCCTACTTGAAACAATGAAAATGTTTCCGGGTGCAACTGAAAAAGCAACAGAATCCGATGAAAATAAGAAAATTTGGTTAGTTGCACCCTTTGAATCAAAGACTGAACCTAAACTAAAAAATTTCGATATTGAACTGTCTAATTTGGAAATACTAAAAGCCGAATTCTTAAACTTTAAACCACCTTCCTATGAAGATGAAATTACGAATGATTCGCAATCCGATCTGAAATCTAACTTTTCTGAAACTACGAGCGAACAGACGTATATTGATCTTGGCCGCGATGATATAAACCTGAGCTTAGAGCAACGCGGCATAGAAAAACCGGATTATCAGAAAAATAATGTCCTACTTGAAGCATCGAAAAAGTTTCCGGGTGCTACTGAAAAAGCAACAGAATCCGATGAAAATAATAAAATTTGGTTAGTTGCCCCTTTTCAATCAAAGGCTGAACCTAAACTTGAAAATTTCGATATTGAACTGTCTAATTTGGAAACACTACAAGCCGAATTCTTAAACTTTGAACCACCTTCCTATGAAGATGAAATTACGAATGATTCGCAATCCGATCTGAAATCTAACTTTTCTGAAACTACGGGCGAACAGACTTTTATTGATCTTGGCCGCGATGATATAAACCTGAGCTTAGAGCAACGCGGCATAGAAAAACCGGATTATCAGAAAAATAATGTCATACTTGAAGCATCGAAAAAGTTTCCGGGTGCAACTGAAAAAGCAAAAGAATCCGATGAAAATAAGAAAATTTGGTTAGTTGCACCCTTTGAATCAAAGACTGAACCTAAACTAAAAAATTTCGATATTGAACTGTCTAATTTGGAAACACTAGAAGTCGAATTCTTAAATTTTGAACCACCTTCCTATGAAGATGAAATTACGAATGATTCGCAATCCGATCTGAAATCTATCTTTTCTGAAACTACGGGCGAACAGACGTATATTGATCTTGGCCCCGATGATATAAACCTGAGCTTAAAGCAACTCGGCATAGAAAAACCGGATTATCAAAAAATTTTCAAAGGTTTGGATAAATATATTCAAAAAGCTGATCAATCTACTACACTGCGACCCTACTGTTGCACGGAATGCAATCAGACGTATGAAGTCGCCGGTCCACTGTACAAACATTTACTCGCGAATCATAATATACGTGCGCGTACAGTATTCCGGTGCAAGGCATGCTTAAAAACGTATATGACAGAAAATTATTTAAGATCCCATTTAAAAAATATACATCTACCGGTTGGCTTCAACTTTACATGCCATTTTTGTGGTCGATCATTTAAATATAAACACGAATTAGTACAACATTTAAACCGGCACAGCGGGATTAAACCATATCAGTGTGACATTTGTCAGTATCGTACAGCTAATAAATCAGACCTTAAATTGCATTTGCGTTCACACACCAAGGAAAGGCCATTCGTTTGCAACATATGTAACATGGGCTTTAGAAGCTCAAGTCACAGGTCTGCGCATATTAAAGAAGCACATTCAGACAATCCCCATGAGTGCAAAATATGTGGAACCGAGTTTACATCGTGGCGGGTTTATCAACGTCATATGCCGCTTCATAACCCAAAAAATATGAATCTTAAATGTGACATATGCCATAAAAATTTCATTCGTAAGAGAACGTGTTTGGCATATAATGACGAATTGGAACCACTATATGCTAAAAAACTAGTGGATACAGACTATGAGGATATAACTACAATGATATTTCTTTGTACTGGATTAGAGATTTCCAAAGGTGATCAACTATCTGATACAATTTGTACGCAATGCATCGATTCGATTATAGCAGCATTTAAATACCGTAAAAAGGTTTGGAAATCAAATAATGTCCTACTTGAAGCATCGAAAATGTTTCCGGGTGCAACTGAAAAAGCAACAGAATCCGATGAAAATAATAAAATTTGGTTAGTTGCCCCCTTTGAATCAAAGACTGAACCTAAACTAGAAAATTTCGATATTGAACTGTCTAATTTGGAAACACTAGAAGCCGAATTCTTAAACTTTGAACCACCTTCCTATGAAGATGAAATTACGAATGATTCGCAATCCGATCTGAAATCTAACTTTTCTGAAACTACGAGCGAACAGTCGTTTATTGATCTTGGCCGCGACGATATAAACCTGAGCTTAGAGCGCGGCATAGAAAAACCGGATTATCAGAAAAATAATGTCCTACTTGAAGCATCGAAAAAGTTTCCGGGTCCAACTGAAAAAGCAACAGAATCCGATGGAAATAATAAAATTTGGTTAGTTGCCCCTTTTCAATCAAAGGCTGAATCTAAACTTGAAAATTTCGATATTGAACTGTCTAATTTGGAAACACTACAAGCCGAATTCTTAAACTTTGAACCACCTTCCTATGAAGATGAAATTACGAATGATTCGCAATCCGATCTGAAATCTATCTTTTCTGAAACTACGGGCGAACAGACGTATATTGATCTTGGCCCCGATGATATAAACCTGAGCTTAAAGCAACTCGGCATAGAAAAACCGGATCATCAGAAAATTTTCAAAGATTTGGACAAATATATTCAAAAGGCTGATCAATCTACTACACTGCGACCCTACTGTTGCACGGAATGCAATCAGACGTATGAAGTCGCCGGTCCACTGTACAGACATCTAGTAGCGAATCATAATATACGTCTGCGTACAGTATTCCGGTGCAAGGCATGTTTAAAAACTTATATGACAGAAAATTCTTTAAGAAGCCATTTAAAAAAGATACATCTATCGGTTGGTTACAAGTTTACATGCCATTTTTGTGGTCAACCATTTAAATATAAATGCGTATTAGAAGAACATTTAAACCGGCACAACGGGATTAAACCATATCAGTGTGACATTTGTCAGTATCGCACAACTAATAAATCCGCCCTTAAATTGCATTTGCGTGCACACACCAAGGAAAGGCCATTCGTTTGCAACATATGTAACATGGGCTTTAGAAGCTCAAGTCACAGGGCTGCGCATATTAAAGAAGCACATTCAGACAAACCCCATGAGTGCAAAATATGTGGAACCGAGTTTACATCGTGGCGGGTTTATCAACGTCATATGCCGCTTCATAACCCAAAAAATATGAATCTTAAATGTGACATATGCCATAAAAATTTCATTCGTAAGAGAACATGTTTGGTATATAATGATGAATTGGAACCGCTATATACTAAAAAATTAGTGGATACGGACTATGAGGATATAACTACAATGATATATCTTTGTACTGGGTTAGAGATTTCCGAAGATGATCAATTATCTGATACGATTTGTACGCAATGCATCGATTCGATTATAAACGCATTTAAGTTTCGTGAAAAAGCTTGGGAATCAAATAATGTCCTACTTAAAGCATCGAAAGTGTTGGCGAGTGCACAAGATAGTTGTTACACAAAATCGGATGAAAATAATACTAATATATTTGTTGCTCCCCTTGCGTCAAACATTGAATTTAAACTAGAAAATTGCGAAGTTGAACTGTCTAATTTGAAAACACTAGAAGCTGAATACTTGAGTTTTGAACCTTACTTTGAAGATGAAAATGAGTGTGATCCACAATCCGAACTGGAATGTGACCTTTCTGAAGCTACGGGCGAGCAGACGTATATTGATCTTGGCCCCGATGAGAAGAACCTGAGCTTAGAGCAACTCGGCATAGAAAAACCGGATTATCAGAAAATTTTCAAAGATTTTCACAAATATATACAAATAGCTGATAAATCTATTACTTCGCGGCCCTATTGTTGCACGAAATGCAATCAGACGTATGAAGTAGCTGGTCCACTGTACAAACATCTACTCGCACATCATAATATACGTGTCCTTACAGTATTCCGTTGCAAGGCCTGTTTAAAAACGTTTATCAAAGAAAGTCATATAAGAAAACATTTAAATAACGCACATCAGCCGAACCCGTTAACCCAAAATTTTGTCTGCGATTTATGCGGTAAATCATTTAAACATAATTCTAACTTAATCATACACCTAAACCGGCATAACGGGATTAAGCCATTTCATTGTGATCTTTGTCAGTTTCGTGCTGTATCTAATACTGAACTTAAATTGCATTTGCGTTCACACACCAATGAAAGACCTTTCATTTGCAACATATGTAACATGGGCTTTAGATGCTCAGGTCACAGGTCTGCACATATTAAAGAAGCACATTCAGACAATCCCCATGAATGCAAAATATGTGGAATCGAGTTTACATCGTGGCGGAATTATAAACGGCATATGCAGCACCATAACTCAAATATGAATCTTAAATGTGACATATGCCAGAAAAAATTCATTCATAGGAGGTATTTGAAGTTGCATATGAGACACCATGGAGAGAAAATGTTTAAATGTTCTGTATGCGAGAAAGCTTTTCATCAGAAACAAAACTGCAAGAACCACATGAAAAAAGCACATAATTCCATATTATAA
Protein Sequence: MDLICRTCLAYNDELEPLYAKKLVDTDYEDITTMIFLCTGLEISKGDQLSDTICTQCIDSIIAAFKYRKKVWKSNNILLETMKMFPGATEKATESDENKKIWLVAPFESKTEPKLKNFDIELSNLEILKAEFLNFKPPSYEDEITNDSQSDLKSNFSETTSEQTYIDLGRDDINLSLEQRGIEKPDYQKNNVLLEASKKFPGATEKATESDENNKIWLVAPFQSKAEPKLENFDIELSNLETLQAEFLNFEPPSYEDEITNDSQSDLKSNFSETTGEQTFIDLGRDDINLSLEQRGIEKPDYQKNNVILEASKKFPGATEKAKESDENKKIWLVAPFESKTEPKLKNFDIELSNLETLEVEFLNFEPPSYEDEITNDSQSDLKSIFSETTGEQTYIDLGPDDINLSLKQLGIEKPDYQKIFKGLDKYIQKADQSTTLRPYCCTECNQTYEVAGPLYKHLLANHNIRARTVFRCKACLKTYMTENYLRSHLKNIHLPVGFNFTCHFCGRSFKYKHELVQHLNRHSGIKPYQCDICQYRTANKSDLKLHLRSHTKERPFVCNICNMGFRSSSHRSAHIKEAHSDNPHECKICGTEFTSWRVYQRHMPLHNPKNMNLKCDICHKNFIRKRTCLAYNDELEPLYAKKLVDTDYEDITTMIFLCTGLEISKGDQLSDTICTQCIDSIIAAFKYRKKVWKSNNVLLEASKMFPGATEKATESDENNKIWLVAPFESKTEPKLENFDIELSNLETLEAEFLNFEPPSYEDEITNDSQSDLKSNFSETTSEQSFIDLGRDDINLSLERGIEKPDYQKNNVLLEASKKFPGPTEKATESDGNNKIWLVAPFQSKAESKLENFDIELSNLETLQAEFLNFEPPSYEDEITNDSQSDLKSIFSETTGEQTYIDLGPDDINLSLKQLGIEKPDHQKIFKDLDKYIQKADQSTTLRPYCCTECNQTYEVAGPLYRHLVANHNIRLRTVFRCKACLKTYMTENSLRSHLKKIHLSVGYKFTCHFCGQPFKYKCVLEEHLNRHNGIKPYQCDICQYRTTNKSALKLHLRAHTKERPFVCNICNMGFRSSSHRAAHIKEAHSDKPHECKICGTEFTSWRVYQRHMPLHNPKNMNLKCDICHKNFIRKRTCLVYNDELEPLYTKKLVDTDYEDITTMIYLCTGLEISEDDQLSDTICTQCIDSIINAFKFREKAWESNNVLLKASKVLASAQDSCYTKSDENNTNIFVAPLASNIEFKLENCEVELSNLKTLEAEYLSFEPYFEDENECDPQSELECDLSEATGEQTYIDLGPDEKNLSLEQLGIEKPDYQKIFKDFHKYIQIADKSITSRPYCCTKCNQTYEVAGPLYKHLLAHHNIRVLTVFRCKACLKTFIKESHIRKHLNNAHQPNPLTQNFVCDLCGKSFKHNSNLIIHLNRHNGIKPFHCDLCQFRAVSNTELKLHLRSHTNERPFICNICNMGFRCSGHRSAHIKEAHSDNPHECKICGIEFTSWRNYKRHMQHHNSNMNLKCDICQKKFIHRRYLKLHMRHHGEKMFKCSVCEKAFHQKQNCKNHMKKAHNSIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -