Basic Information

Gene Symbol
HIVEP1
Assembly
GCA_021155775.2
Location
CM037744.1:19081233-19098025[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 6.9e-05 0.01 17.1 0.6 1 23 154 176 154 176 0.98
2 9 0.032 4.8 8.7 2.0 1 21 182 202 182 206 0.86
3 9 0.0014 0.21 13.0 0.1 1 21 406 426 406 427 0.96
4 9 1.5e-06 0.00023 22.3 1.6 1 23 1159 1181 1159 1181 0.99
5 9 6.9e-06 0.001 20.2 5.2 1 23 1187 1211 1187 1211 0.92
6 9 2.1e-06 0.00032 21.8 0.1 2 23 1866 1887 1865 1887 0.97
7 9 0.00055 0.083 14.3 1.3 1 23 1893 1917 1893 1917 0.92
8 9 0.0014 0.22 12.9 3.3 1 23 1938 1962 1938 1962 0.93
9 9 0.5 76 4.9 0.6 1 19 2127 2145 2127 2150 0.93

Sequence Information

Coding Sequence
ATGGTGCATCTACTGAATGTTGGTCAGGGTTTGTCCGACTGCATCTGGTTGTCTCAGCCTCCTGCGGTCGGTGAGTTGCTTCGGTATGAAGAGAGTCTCAGCGTCCGGGGACCGCCACCGAGTGTTCGTGACTCATTCGTCATAGTCCGGGATTCTCTAACAGCGGATATAATACAGACTCATACTGTGGCAATGACAGACTCGCAGTtgaataacaacaacaacaataataataacaacaacaacgatgGCGAACCTAAATACTTGCACAAGAAATTCAAGAAGATGGCGACGACAGAGGCGACGCCGGTGGAATCCAAGCGAGAAACAACCTCGGATAGCCGGATCCCTGGTAATCGTAGGGAGAAAGATGGTGAGGATTCAGCGAAGGAACCAGCAGCGAAGACTGAGGCCGCCCCCGAGCCCGAGGGGGAAGCCAACGAAGGCAGGAAGAGTGGATACGTATGCCCGTACTGCAAATTGTCCTGTGCCAAACCCAGCGTACTACAGAAACACATCAGGGCTCATACTAATGAGAGACCCTATCCATGCGTTCCCTGCGGGTTCGCGTTCAAGACCAGATCGAACCTCTATAAACACTGCAGATCTCGAGCCCATGCTCTTAAAATGGAAGGAGGAGACTCTAGCAAGGTTTCAGAAGATTCTGACATAAGCTTGTCGGATAGCGCGAGTAACGGAACAGGAACACCACCTCCGCCACCGTCGTCGACGCCAAGTTCAGTGTTGAGCGTGAAGACAGTGAAAACGGgtaaaatttacaagccaaaaTTTCACACGGCCTTAAACAATGTGAGCCACGATGTAGAAGCGTCATCGGTTTCGTCGAACTCCTCGACGAATTCGTCGACGAACTCGAAGCCGAACGCTGAACAGCTGCAGGAGCACATAGACAAAATAATAACAGCCAATCAGGCAATCGTGGAGGCGGTAGACCCACTACTTCACAAGCTGATGCAAAGGCAGCAGAGTTTGGTGGAACCAAAGTACACTGAGCAACCGTTAAATCTCTCATCGGCGGAAGAAAACTTGACGAGGAAGCGGTGCTACAGCGAAAGTTTCGCCCACGAGAAGGATGGTAAGCAGCCGCAGAATCATcaccaccagcagcagcagcagcaagaAGCATCGATAATAAAGGAGCTTCTCTTGAAGTCTAAGGCGCATCAGAACTGCGATGGTGTGGATGGTGAAAACTTTGTCTGCCCGTCGTGTAAAATCTCTTATACTAGCGCCGATAACCTTGACGCCCACAGGCGGTACTACTGCAAAGGATCGCCTAGCCCGAGGCGACCCGAATTTCAGCTTGACCTCGACAGAAAAGACCCGGAGTTCGAGATGAAACCCGACTACTACAACACCCTCCAGCCACTCCCGTCGCCGGGTCCGCTTCTTGGTAACACGAGATTAGTCGACCCCTACGTACCGCCAATGAAACAGAGATCTGAATCCGCGCCAACGACACTGAGGTCGCTGGAGGAACTGTCCAAGTATCCGAGACCAAACTCGCTCCAGATGTTTGGTGGCGAAGTGAGGATACTCAACGACACCGGAGAGACGAAAACGATGAGGATAGAACCCCGTCAAACGAATTCACCTGGTGAACAGCACTCGGTTAACGGCAAGTGCGCAACTTCGGAGACTTCCTCGATAGTGGTTAGGTCTGGACTTCACTCCGGCGGAACCATGGTTCACAAACCGCCCGGCACTCCAGCCAGCACAACGAACGGTTCCATATCCCTGCCAAATACACCGAAGATATTGGCACCTATCATACCCAACATATCAACTCCTAACATAGCGCCAACGATATCCTGTTATAGTTACTTAGAGCAGAACCTCAACCCCCTAACGAACATCACGGCCTACAATCCGCTAACCTTGCCGCAGGCTGGTATAGCTAGCATTTTGCACGGCGGTAAGATCATACCTTACGTACCTGGCATGCCTGGTCCCCACACTTTGTCCGGAACACCTTCGGTCGACATATCCGCCAACGTACCCAGTGCCGAGGCCGAGTACAAGGTGATTCCCGGTATCCCCGGACTCCACGTCGTTACTCAACCCCTGGATCTCGCCAGTCCCGTCAAAATTCATACACCCAACATTCCGGGTATACCTGGACCGCATTCCAACATGCAAATGCCGTCACCCGCTCAGCCGTTGGACCTCGCCAGTCCAGCCAAGGAGCTTAAACTCTGCTTCAAGACTCCGAGTAGTGATAATTTGCGGTCCGGTTTGATGAGCCCAAAAGTTCCTAATCTCAAGATTGAATCTACCCCGGATAAATTCAGGTCCAGAGTGCCCAGCGGTGATACGCATAGATCGGAGCATGATCGTTACAACTTGAAATCTGGGATCAAGTACAGTAAGAGTAGTACTGAGAGCCCGAGGGAGAGGAAGGaattttcgtttgaaaaaagtcCGTGCAAGACGGAAAAGACTTTCACATATCCAAACGACGCTGATAGTATGCAGAAGCTTAGATACTCGCCGAAAAATCTTACCGAAAGTAGAAAGAGGCCAAGTAGCTGGGCCAGTGCGGAATTTGAACAGGGCCGATCGTCCTCCGCCGAGTCTGTGAGACAGAGTCCCGTGGTTTTCAAATACGAAACGGTGCCCCATGAAAACGGCCGTACGAAATTAGCGGCGTTACAGTTGCCGGGAAATGTTCAACAGGATGTTAAGACAAGGACGTTGCAAATGGAAAATTGTGGAGCGATGAACGGAATAAAGTCAAAACACGAGTTTCAAAATGCTCCGGTTATAACTGTTAATCTAGATTCTTCCAATACAGAAGTGCCAAGTAAACCTTCACATGGTGATTTATTAGCTATTAGTCGTGAAAGTAAACCAGCGGACAGTCTTCACTCACCAAGTATCAGCAACGAAGACGCAACCGGAGTTGAAGAGAGTAACACCAACAATAAATTTCTGAGGCCGACTTCGCTGCCTCTTAAGCCTGGTACCTTTACCCCAAAACGACACCACGGTATAACGCCAACGGCGAACACGTTGCCCCTGATAAGCCCGGAAACACCGAGGCCGAGGAAATCGTACGGTCAACTGTATTTGAACGGACATGCGTACACCTACCTCGGGCTGAAATGTTCGACTCGAGTATTTTACTGCACATTAAACAGGCCTCAGCCGATGTACGTTACTCAACAACACACCCTGTCTATGTACTCGAACTGGAAAATATGCAAGGAGGCACCACTCGACCTCGACTTGGCCCATTACGACTCGAGACGCCGGCCCATGAGCTACACCACGGCCTCGAAGAAACACGACGATATTTTAACGCATTCCTCGCAAAGACCTACAACCCCTGCAAGCTCGGACAACAACTCCGAAAATGATACTCAGGAAAAAGCTAAACGGGTCAAGATATTCGACGGCGGTTTCGAGAGCAACGAAGATTACATATACGTCAGAGGAAGAGGCCGAGGAAGGTACGTCTGTGAAGAGTGTGGCATCAGATGCAAGAAACCATCGATGCTGAAGAAACATATCAGAACGCATACCGATGTCAGACCATATACCTGCAAGCACTGCACTTTTAGTTTTAAAACAAAGGGAAACCTGACGAAGCACATGAAGTCAAAAGCGCACTACAAAAAATGCGTTGAACTCGGTGTAGTTCCAGTTCCGACGTTGGTGTGCGATGAGAACATCGACAAGGAGGCGGTTGCCAGATTGGCGGCGGGCGGAGGAAACGGCGAAGAATCCTCGGAAGAGGAGGACGAGACTGACGGCGAGGAGAGCGAGGAATCCGGAAGCGAAGAGCACGACGCTGTTCAGGGATTGCTGAGCTTGTCTCAACCCAGCACGCACCGACTGCCGGGGCTGCTTCCGTCAGGCAGGCCAACGACATATCCGTACACCCTGACCTTTTCCCAGAGTACAATTTGCACGGCGGTCGTAACAACGACGAACAGTTCAGCGCCGCTGAGCAGCCAAGCCGCGGCTGTGATACAGAGTGATTTGTCCCACCGTTATTACTTCCCTTCGAGTCGTGCGGTACTCGAGAAATCAAGGACCAGTGTGATAATACAGTCTTCCAAAAAGCCCGGGAACGATACGGCGGAGGTAAATGATGATTCGTCGGTTCACGCTACCGATTCACAGATCAATTTTCACCAGCCCATAGACCTCACGACCAAACAAACACTCGGCCCAATAAGTTCTCCAATTCTCCAACGAGTCAAGCCTGCCGATATCCTGACCCCGGTCTCCGAGCAGCTTTTGATGCAGACGATTGTCCAGACCATGGAAAGACTTCCGGTGCAGGGTAAGGAGTGGAAATCCGAGGCCAAAGGACACATGCTGCAGGCGTATCTTACCGAAAGACACGTGATGGACAGTAAAATGAAGCTGCAGTATCGAGTGTGCTGCTCAAAGCTCGAGAACAACTGCACAGAGAAGGATAATATACAATACTTGAAGCAGCACGACACAATCAGATCGAAGAATTTAGATCTAAACGGGGTGTCCACCGTGACTTACACGAACCCCAGCAAGATGCAGCATACCATACTAGAGTCGAGAATTAAAAGTATTTACAAGCAGACGCAGCAAGACTGTATGAAAATTCCTTACAATGAAGATGTCTACCAAAACAACGCTTACCTTGAGACGCGGTCTTTTGACGCGGTCGATTCATCCTATAAGGACACGGAGAACGCGGGTCGGATGGTGGGCGAAACTGACGGTTTTGACCACCGAGTCGGAAGAGGCGGAAGCCCCATTCCGACCATTTACAAAGGCAGCTTGCCGGGGCGAAGTACACCAACTTTGGACCGTCAGTCACCTCGAAATTTGAACGTGGAGATGACGAACCGAAACGCGTCATCTATCCACGGACAGGTGAAGAGTGAGATAGACAGGAGCTCGATGTTCAACGCAATGAAAATGATGAGCGAGGTGGAGAGGCCGAGGGACAGCTTCACTCCTAGCCAGGATCCAAAGCCCCTGAGTCGAGAAACCAGGGTTCAATGCAACCAGAGTCCAAGATCTCATCATCAGGAATTACGGCCGCCGAGTCGAGAGATTCGCGTCACTTCTTCGCCTAGTCAAGAGTTTAAGCTGCCGAATCAAGAGCTTAGGCTACCTAGTCAAGAGTACAAGCCGGCTAATCACGAACCAAGGAGTTCCAACAGCCAAGAAATATCCGTGTCGTCTAATACGAATTCGGAAGTCAGCCAACCAAGCAGAGAAATAAGGCTGCCTCAGGCACAAGACCAACAGTCCAGGCCAAATTTCGAGGTGAAATCTTCATCGGGGCACGATATTTCCAGGGCTAATTTGCAGGAGGTGCAAAACAAGTCGCAAACAGCTGTTGATCCGAGGAATTCTGAGCGTGCGGAGATTAAGCAGAACGTCGACATGACCAAGCAGAACATGGCCGAAGGCATTAAGCACTCCGTGGCCCGAAAAATGGTCGTTGGTGGGCCCGGATTTAGATCTCCGTCACCACCAGGTGGAAGTGGGAAACCTCACGCTGAATTTTTGCAGCCGTCAAGTGGACCTGCCCCAAATTACGTGAGTTACAGCGTGACTGAAGATGGTAGAAGCGTGTGTGGAATCTGCAACAAAGTGTTCAGCAAACCGAGTCAGCTCAGGCTACATATCAATATTCACTATTTTGAGCGGCCCTTCAGGTGCGAGAGTTGCGCTGTATCGTTCAGGACCAAAGGCCACCTCACAAAGCACGAGCGCTCGGTTGCTCATCACAACAAAGTAAGCATGACGTCCACTTTTGGCGCTGCTACAACGAGCAATCCTCGACCGTTCAAGTGTACGGACTGCAAGATTGCTTTCAGGATACATGGACACCTCGCTAAGCATTTGCGAAGTAAAATGCACATCATGAAGTTAGAGTGCCTGGGAAAATTGCCGTTCGGTACTTACGCGGAAATGGAAAGATCCGGCATTAATCTAAACGACATCGATACTAGTGACTGTGATAATAGTCTAACTAGTCTACAGAGCTTAGCGCAGAAACTCTATGAAAAGGATCCGAGTAAGATGGGTCAGTGGGATGCCGATTTGATTCCAAACCAAGGCGCAAGTGGGGGAGACACTTCATCTGACGAGGGCGAGCCGATCCCAATGCATTCAATGCATCAGTATCCGTCTCCAATAGGAATGTCGGAGAGCGAAGTATCGCGGGGATATCACATGCCGATACTAGTTAGTGAGGAGTTGAAGCCGGTGGGTGAAATTCGTCACGCAAATCCACAGTTCAATCAGCAGCGGCAAACTGACTTCGGAATCAACGAGAGGCAGCATCGACCATCACGAATTCCAGCTCCAGCTCCCAGCGACGACTCAAGGACTGAAGAATCTGGGCAAATGTATAAGTGCAACATTTGCTCGGTGTCAATACGCTCCGTCGCTGAATTGCAGATTCACTGCTTTAGCGAGCACAATATCGAGCCTGAATCATCTGCAAGTGGTGATCGGAATGGCAGCGAGGGCAGGGATGTCAGTGATAATCGTAACAAAAGAGGATTAACCGAAGATGGACCGATCGGTGTTATCAGGGACGATCATAAGAGACAGAAAGTTGTTGATGATACTTAG
Protein Sequence
MVHLLNVGQGLSDCIWLSQPPAVGELLRYEESLSVRGPPPSVRDSFVIVRDSLTADIIQTHTVAMTDSQLNNNNNNNNNNNNDGEPKYLHKKFKKMATTEATPVESKRETTSDSRIPGNRREKDGEDSAKEPAAKTEAAPEPEGEANEGRKSGYVCPYCKLSCAKPSVLQKHIRAHTNERPYPCVPCGFAFKTRSNLYKHCRSRAHALKMEGGDSSKVSEDSDISLSDSASNGTGTPPPPPSSTPSSVLSVKTVKTGKIYKPKFHTALNNVSHDVEASSVSSNSSTNSSTNSKPNAEQLQEHIDKIITANQAIVEAVDPLLHKLMQRQQSLVEPKYTEQPLNLSSAEENLTRKRCYSESFAHEKDGKQPQNHHHQQQQQQEASIIKELLLKSKAHQNCDGVDGENFVCPSCKISYTSADNLDAHRRYYCKGSPSPRRPEFQLDLDRKDPEFEMKPDYYNTLQPLPSPGPLLGNTRLVDPYVPPMKQRSESAPTTLRSLEELSKYPRPNSLQMFGGEVRILNDTGETKTMRIEPRQTNSPGEQHSVNGKCATSETSSIVVRSGLHSGGTMVHKPPGTPASTTNGSISLPNTPKILAPIIPNISTPNIAPTISCYSYLEQNLNPLTNITAYNPLTLPQAGIASILHGGKIIPYVPGMPGPHTLSGTPSVDISANVPSAEAEYKVIPGIPGLHVVTQPLDLASPVKIHTPNIPGIPGPHSNMQMPSPAQPLDLASPAKELKLCFKTPSSDNLRSGLMSPKVPNLKIESTPDKFRSRVPSGDTHRSEHDRYNLKSGIKYSKSSTESPRERKEFSFEKSPCKTEKTFTYPNDADSMQKLRYSPKNLTESRKRPSSWASAEFEQGRSSSAESVRQSPVVFKYETVPHENGRTKLAALQLPGNVQQDVKTRTLQMENCGAMNGIKSKHEFQNAPVITVNLDSSNTEVPSKPSHGDLLAISRESKPADSLHSPSISNEDATGVEESNTNNKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPRKSYGQLYLNGHAYTYLGLKCSTRVFYCTLNRPQPMYVTQQHTLSMYSNWKICKEAPLDLDLAHYDSRRRPMSYTTASKKHDDILTHSSQRPTTPASSDNNSENDTQEKAKRVKIFDGGFESNEDYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYTCKHCTFSFKTKGNLTKHMKSKAHYKKCVELGVVPVPTLVCDENIDKEAVARLAAGGGNGEESSEEEDETDGEESEESGSEEHDAVQGLLSLSQPSTHRLPGLLPSGRPTTYPYTLTFSQSTICTAVVTTTNSSAPLSSQAAAVIQSDLSHRYYFPSSRAVLEKSRTSVIIQSSKKPGNDTAEVNDDSSVHATDSQINFHQPIDLTTKQTLGPISSPILQRVKPADILTPVSEQLLMQTIVQTMERLPVQGKEWKSEAKGHMLQAYLTERHVMDSKMKLQYRVCCSKLENNCTEKDNIQYLKQHDTIRSKNLDLNGVSTVTYTNPSKMQHTILESRIKSIYKQTQQDCMKIPYNEDVYQNNAYLETRSFDAVDSSYKDTENAGRMVGETDGFDHRVGRGGSPIPTIYKGSLPGRSTPTLDRQSPRNLNVEMTNRNASSIHGQVKSEIDRSSMFNAMKMMSEVERPRDSFTPSQDPKPLSRETRVQCNQSPRSHHQELRPPSREIRVTSSPSQEFKLPNQELRLPSQEYKPANHEPRSSNSQEISVSSNTNSEVSQPSREIRLPQAQDQQSRPNFEVKSSSGHDISRANLQEVQNKSQTAVDPRNSERAEIKQNVDMTKQNMAEGIKHSVARKMVVGGPGFRSPSPPGGSGKPHAEFLQPSSGPAPNYVSYSVTEDGRSVCGICNKVFSKPSQLRLHINIHYFERPFRCESCAVSFRTKGHLTKHERSVAHHNKVSMTSTFGAATTSNPRPFKCTDCKIAFRIHGHLAKHLRSKMHIMKLECLGKLPFGTYAEMERSGINLNDIDTSDCDNSLTSLQSLAQKLYEKDPSKMGQWDADLIPNQGASGGDTSSDEGEPIPMHSMHQYPSPIGMSESEVSRGYHMPILVSEELKPVGEIRHANPQFNQQRQTDFGINERQHRPSRIPAPAPSDDSRTEESGQMYKCNICSVSIRSVAELQIHCFSEHNIEPESSASGDRNGSEGRDVSDNRNKRGLTEDGPIGVIRDDHKRQKVVDDT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01048436;
90% Identity
iTF_01048436;
80% Identity
-