Basic Information

Gene Symbol
SNAI1
Assembly
GCA_963243735.1
Location
OY725354.1:12004093-12007174[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00041 0.069 15.1 0.7 1 23 314 336 314 336 0.95
2 12 7.6e-05 0.013 17.4 1.6 1 23 344 366 344 366 0.99
3 12 1.6e-05 0.0027 19.5 0.3 2 23 374 395 373 395 0.97
4 12 1.1e-05 0.0019 20.0 0.4 1 23 401 423 401 423 0.98
5 12 1.2e-05 0.0021 19.9 2.4 1 23 430 452 430 452 0.99
6 12 6.6e-05 0.011 17.6 0.4 1 23 458 480 458 480 0.96
7 12 1.4e-05 0.0024 19.7 0.1 1 23 486 508 486 508 0.98
8 12 8.5e-07 0.00014 23.5 1.2 1 23 514 537 514 537 0.96
9 12 6.1e-05 0.01 17.7 0.7 1 23 543 566 543 566 0.91
10 12 4.8e-05 0.0082 18.0 2.8 1 23 572 594 572 594 0.99
11 12 0.00013 0.022 16.7 0.4 1 23 600 622 600 622 0.94
12 12 0.0034 0.58 12.2 0.1 1 21 628 648 628 652 0.92

Sequence Information

Coding Sequence
ATGCCTTCCAGTGGGATTTCTTGTATTGTTTGCAATGTTGGATGCGTTCCAAGCACGGACTACATTGAAATATTTAGCAAAGATCCTGCTACAGAAACCGATTTGCATATAGCTACACTAGTTGCTAAATTATTAGATAAAGATATTAAACCAGATCCAAATAATCATCAACTTATTTGCAAGAAatgttttactttaataacAGAACTTGAGGAATTGCAAACTAGGGTTGCTGaaataaaaagtgaaatattCGTACACCAAGACTCTgaaactactttaataaaggaaGAGAATGAAGAAAAGACTGAAGAGGGTAATAAGGAGAATGCAAACTCtaagaaaatgttatttattccATCTTCAGACGAGGATTCCACACAGGTTCCTACCGAAAAAACTAGTTTTGATGACATAAATCTCGAGCTAGCTAGAATGCATGGTGTTGATATTGGAGATATAGAACAGCAAGAAAAAGATAATGCTGAAATAGAGATGGAAACCAGCATTAATTATCAAAGTTTTTCaactgatgatggcgaaataATTGATTCTGGTGCAATTGAACATTCGTCAGATTCTGATTATGAACCACAAATTTCACCTTCACCCTTTATCAAACCTTCCTCATTTGTAGAAATTCCTCTTAATGATAAAGaaATGAATTTGAAACTTAATCTTGTTGGTAATGAAAACACTATAAAAAATCCATCTATAAACTTGGATAAAAAGCCTATTAtcctaagaaaaaaaattccaacacTTCCACTTGAAATATCTGGAGAAGATGATAGAAAATTAGATTCTACCATTGCAGTGCCTGTAGTATCGAAGGAAGGAAATTTATATACTTGTCTTCTTTGTGAAGGAGATGAAACCGTAGCTGGTGAATCAAAAGCAATTGTAGCCCATGTAAAGGATGCCCATGATGTGCGATTATACATCTGTGATGTTTGTGGACAAGATTTTTGCAAACGAAATCAACTTTCTGCTCATTTAGATGAACACGTAGCTGCTGAAGATGGAGATTTTCAGTGTGAAGTATGCAatagaattttcaataatctCAGATTATTTAGAATTCACAAACGTATGCATTATCCGCAGAGTAAGGCTTGGGTGTGTGATACTTGTGGGAAGAAATACAGCAGtaaaaatcttttagaagaGCATGTTAATACCCATTTAGgTGTTCGTCCGTATATATGTGGGGTATGTGGTAAAGATTTTGCAAGTAAATACACTTACAAAGCACATGAAAAGACCCACGAAGTGCGACCGAGACCATACAAGTGTAGCCAATGTGATAAGTCCTTTTTAAGTCAACAAAACCTTACACAACATGAACGTACCCACTTAGGAATGAAAGAGTATTCCTGTCAATTATGTGGAAAACAATTTGGTTCAGCTCACAACCTGGAAGTTCATTCAATAGTGCATACTGGATATAAACCATTTGTTTGTGGTTTATGTGGTAAAGCATTTGCTAGGAAAGCAGAAATTAGAGATCATGAAAGAACCCACACAGGTGAAAGGCCATACCAGTGCGAATTTTGTGGAGCAACTTTCAGTCAAAGATCAAACTTGCAATCTCATAAGAGAGCAACCCACTACGACGACAAACGGTACCAATGCACAATTTGTGGTAAAGGATTTAAGCGGAGGCGCCTCTTAGATTATCATAATAAAGCAGCTCATACAGGTGAAAGACCTTTCAAATGTGAAACTTGTGAAGCCACTTTTGTTTACCCTGAACATTTCAAAAAGCACCGTCgaattcatactggtgagaaaCCGTTCCTTTGTGAAGTATGTGGCAAGGCCTTCAACAGTAGAGATAATCGTAATGCTCATCGTTTTGTCCATTCTGATAAGAAACCCTACGAGTGTCTCGTATGTGGAGCCGGATTTATGAGAAAACCTTTGCTCtatcaacACATGCAAGCCCAGGGTCACCTGAACGACACAATAGTCGTCAATCAGCCTAGATTGACTACGGAAGATGATCAGTTGGTAACAGTTAATGCAGCTGGAGAAATGGAAATCGTCGATGCTTCCTCGACAGAAGGAAAATTGTATATACAAGACCAGGATGGTACTGAACATATAATTATCGATGGACAACAGATTAGTTTTGCTGAAGTTGGCAGTGACGATGATAATGACGAGATTATTGATGAAATTGAgcaggTAGTTACTGATCAAACAGATGAAGATTACGAGGAAATAATAACCAGCGATGCTCTAGCAAATGGAGAAACGCAAATAATTGAGACTCCTGATGGACCAGTACAGTTAGTGAAAGTTCGGATACCAAATGAAAATGGGGAAGAGGAAGAAGCATGGATAAAGATTGTTCCTGAATaa
Protein Sequence
MPSSGISCIVCNVGCVPSTDYIEIFSKDPATETDLHIATLVAKLLDKDIKPDPNNHQLICKKCFTLITELEELQTRVAEIKSEIFVHQDSETTLIKEENEEKTEEGNKENANSKKMLFIPSSDEDSTQVPTEKTSFDDINLELARMHGVDIGDIEQQEKDNAEIEMETSINYQSFSTDDGEIIDSGAIEHSSDSDYEPQISPSPFIKPSSFVEIPLNDKEMNLKLNLVGNENTIKNPSINLDKKPIILRKKIPTLPLEISGEDDRKLDSTIAVPVVSKEGNLYTCLLCEGDETVAGESKAIVAHVKDAHDVRLYICDVCGQDFCKRNQLSAHLDEHVAAEDGDFQCEVCNRIFNNLRLFRIHKRMHYPQSKAWVCDTCGKKYSSKNLLEEHVNTHLGVRPYICGVCGKDFASKYTYKAHEKTHEVRPRPYKCSQCDKSFLSQQNLTQHERTHLGMKEYSCQLCGKQFGSAHNLEVHSIVHTGYKPFVCGLCGKAFARKAEIRDHERTHTGERPYQCEFCGATFSQRSNLQSHKRATHYDDKRYQCTICGKGFKRRRLLDYHNKAAHTGERPFKCETCEATFVYPEHFKKHRRIHTGEKPFLCEVCGKAFNSRDNRNAHRFVHSDKKPYECLVCGAGFMRKPLLYQHMQAQGHLNDTIVVNQPRLTTEDDQLVTVNAAGEMEIVDASSTEGKLYIQDQDGTEHIIIDGQQISFAEVGSDDDNDEIIDEIEQVVTDQTDEDYEEIITSDALANGETQIIETPDGPVQLVKVRIPNENGEEEEAWIKIVPE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00387446;
90% Identity
-
80% Identity
-