Basic Information

Insect: Neoceratitis asiatica
Gene Symbol: topi
Assembly: GCA_030068015.2
Location: CM061528.1:18658754-18661568[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 4.9e-05 0.0034 18.0 2.6 1 23 291 313 291 313 0.97

2 10 0.0081 0.56 11.0 1.0 2 23 348 369 347 369 0.97

3 10 0.053 3.7 8.5 0.1 2 19 431 448 430 450 0.94

4 10 0.054 3.7 8.4 2.3 1 22 499 520 499 523 0.90

5 10 0.26 18 6.3 0.5 2 23 538 560 537 560 0.85

6 10 1.5e-06 0.00011 22.7 2.3 1 23 580 602 580 602 0.95

7 10 0.0036 0.25 12.1 1.1 1 23 608 633 608 633 0.95

8 10 0.53 36 5.3 1.7 1 23 639 661 639 661 0.88

9 10 4.5e-08 3.1e-06 27.5 0.4 1 23 667 689 667 689 0.99

10 10 0.051 3.5 8.5 1.4 3 23 697 718 695 718 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	4.9e-05	0.0034	18.0	2.6	1	23	291	313	291	313	0.97
2	10	0.0081	0.56	11.0	1.0	2	23	348	369	347	369	0.97
3	10	0.053	3.7	8.5	0.1	2	19	431	448	430	450	0.94
4	10	0.054	3.7	8.4	2.3	1	22	499	520	499	523	0.90
5	10	0.26	18	6.3	0.5	2	23	538	560	537	560	0.85
6	10	1.5e-06	0.00011	22.7	2.3	1	23	580	602	580	602	0.95
7	10	0.0036	0.25	12.1	1.1	1	23	608	633	608	633	0.95
8	10	0.53	36	5.3	1.7	1	23	639	661	639	661	0.88
9	10	4.5e-08	3.1e-06	27.5	0.4	1	23	667	689	667	689	0.99
10	10	0.051	3.5	8.5	1.4	3	23	697	718	695	718	0.95

Sequence Information

Coding Sequence: atgaTGAATACAAGTGAAGAAGAGTTTTCGAATTCTGATGCTTGGCTATCCGAGCAACTGTTTGcgcaattaaaagaatttaattcagACTATAGAGAAAATCCAGTTATCGACGCATCAACAACATTTCTATTTCCTTCCGGAAGTCTTTCCTGTTTGCCTGAAGAAGAACCGCACGAATTAACAAAACCACGACATGAAAACTACGAATCTGTTTTCAAACTATCTACACCAACAAATATTCCTAATTTCGATATGAATGATGTGCTGGATTTAACTAATATAACTGGTAGAGGTACCGATTCAGCACTCCTGGATTTAGTTGAGACAGTACCTCCGTTTATTACACCCGTTTCTGAGTCAACAATAATGGTCAATGATACAGAGGGACAAACGACGGCGTTATATGATGCAACAGAAGAGGAattaaagcttttgaaatttttggagtcACAACCATCAACTAATCAGTTTGATACAAAATCATATATTCCAACTGATATTTCACCCACTGCATATGGTGTTGTCAAATGTTCAAACTGCAATGTACTCTTTGACTTATTGTCCTTCCAAACTCATATTTGTGAATATGATGAACATCACAATCTCATTGTTCCACCAACAACATCAACACCTATTAGCAAACCAATAAAAGACGAACCTCTACTACCAGTAGAACCTGCATGTATTCGTTTATTGCGTGAAAATCAAATTCGTATTCGACGGTTTCTTAAAGATGAACTTAAATATGATGTGAATGCTTCAATAAATAGTATTACAAGTAGCTCTGGTAATTCTTCGAATGGCACATCAAACATGTCATTAGGATCCAACTCAACGGCAAATACTTCCAAAAAGCAAGATGGACCACATGAATGTACACTATGCGAACGAAAATTTGTGCATGCATCAGGTCTTTTGCGGCACATGGAGAAACATGCAATGGACCTTATACCTACACCTGGCGTTTTTGCAGGTGGAAAAGCAGCGACATCACAAGGAAGCTCTTTGCAGAGCGTTAATGGGCTACGTGTCGTCATTAAATGTACTTTATGTGGCCGCGTATTCTTTGAACCCAATGCAGCTTTTAAACATTTGTGTTCTCATTTTCCTGGTAGTGctcaagaagaaaaagaatacgATAATTGCGCTGAGATTCCTTATGAGTCTTATGTAGACGAcgctttgaattttttgagcATGGAGACCAATAGCTGTCCTGGAATGATAACAATACACGGATATAAACCTCCAGTTTATCTTAAGATGGTTATTTTAAGCTGCATTTTACAGTGCGAATTTTGTGATTTCGTTTTCTCAGAAGTATCCTATCTGTTTGTACACTCGGCTTGCCATTTGCCAGATCGCCGTTTTGAATGTTTCTCATGCGACATTTATATGCGTACGTCCAAGGAAATTTGTGCACATTGGCAAGCTGAATGTGTATTTATGCGAGAGAATATGAAGGTGCATCAGGCGACCACCCAACGTTATTTTGTTTGTAATGTTTGcgagaataaatttcaaactctTGATCAGTTGCATGAACATAGGTATACATCATACCATTTCTTCCCACGCTTAAATAAAAGCGTTGGTATTCTACAGTTACCTTGTGAGTACTGCGATGCAGTATTTGAAAATGCGCATGAGTGTGTGGCTCATTACGaagaaaaacattataaaaagtataagcGTGATAAAGATGGGACTGGCATGTCAAGTAAAACCCGTCAATACCTGTGTGATATGTGTGGCAAATCGTATACCCAATCAAGTCATTTATGGCAACATTTGCGTTTTCACCAAGGAGTAAAGCCATTTGCTTGCAAGGAACCTGGTTGTACACGTAAATTTACAATCCGTCCAGATTTGAATGATCATATACGCAAATGTCATACGGGGGAGCGTCCATATCACTGTTTAGTGTGTGGTAAACGCTTTCTAACCGGTTCAGTTTTCTATCAACATCGTCTAATACATAGGGGCGAGCGACGTTACGAATGTGAAGAATGTGGAAAACGTTTTTATCGTGCCGACGCACTAAAGAATCATCAACGTATTCATACCGGTGAAAAACCGTTTGGCTGTCTGTTTTGTACGAAGAACTTCCGTCAACGCGGCGATCGTGACAAACATATAAGAGCTAGACATTCACATTTGGATGCCAATGCACGACTGATGATGCAAATGCAAAAACTTAAACTGGAAGCTGCAGCGGCTGCAGCTGCTGCTCAAGTAGTtgttcaacaacaaaataatgtaaataattctGTTATTTCGAATGGAATACCCACTTTGATACCAACGCTCATGAGTGCGCCGTCTGCAGGAAATGATACAATTGATTGCCTGGAACCAGCAATGGATCCGAATGAAGTTGTTATGATTGGAAATGTGGCATTCCCGAAAAGTATGTTTGAATCTATAATTCCAGATATAGATGAAGAATCGGCACTTAGAGTTATGGAACAGTTGCAATAA
Protein Sequence: MMNTSEEEFSNSDAWLSEQLFAQLKEFNSDYRENPVIDASTTFLFPSGSLSCLPEEEPHELTKPRHENYESVFKLSTPTNIPNFDMNDVLDLTNITGRGTDSALLDLVETVPPFITPVSESTIMVNDTEGQTTALYDATEEELKLLKFLESQPSTNQFDTKSYIPTDISPTAYGVVKCSNCNVLFDLLSFQTHICEYDEHHNLIVPPTTSTPISKPIKDEPLLPVEPACIRLLRENQIRIRRFLKDELKYDVNASINSITSSSGNSSNGTSNMSLGSNSTANTSKKQDGPHECTLCERKFVHASGLLRHMEKHAMDLIPTPGVFAGGKAATSQGSSLQSVNGLRVVIKCTLCGRVFFEPNAAFKHLCSHFPGSAQEEKEYDNCAEIPYESYVDDALNFLSMETNSCPGMITIHGYKPPVYLKMVILSCILQCEFCDFVFSEVSYLFVHSACHLPDRRFECFSCDIYMRTSKEICAHWQAECVFMRENMKVHQATTQRYFVCNVCENKFQTLDQLHEHRYTSYHFFPRLNKSVGILQLPCEYCDAVFENAHECVAHYEEKHYKKYKRDKDGTGMSSKTRQYLCDMCGKSYTQSSHLWQHLRFHQGVKPFACKEPGCTRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFGCLFCTKNFRQRGDRDKHIRARHSHLDANARLMMQMQKLKLEAAAAAAAAQVVVQQQNNVNNSVISNGIPTLIPTLMSAPSAGNDTIDCLEPAMDPNEVVMIGNVAFPKSMFESIIPDIDEESALRVMEQLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00081676;
90% Identity: -
80% Identity: -