Nint032751.1
Basic Information
- Insect
- Neoascia interrupta
- Gene Symbol
- lolal
- Assembly
- GCA_947623515.1
- Location
- OX392462.1:174076479-174088562[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 2e-07 0.0024 18.6 0.0 90 141 1 53 1 56 0.87 2 4 5.8e-06 0.07 13.8 0.1 105 137 51 83 43 88 0.82 3 4 9.1e-05 1.1 9.9 0.0 108 136 84 114 82 119 0.74 4 4 1.7e-49 2.1e-45 156.0 1.1 98 210 108 220 104 223 0.93
Sequence Information
- Coding Sequence
- ATGGAAGAGTTAGAAACTGTACTCACAAAACAAGCACCGCCAACACCAACAGAAGATGCAAAACTCTTTGAACTGCCAACTGTATTCATCGGCGGTATTCGAACACCGGTTGAAAAGAAGCCCAAGCTACAGGCGCAATTGCGAGCTCTTACACCAACAGAAGATCCTACAGTCTTTGAACTTCCACCTCTAAACATTGACGGTACTCAAGCACCGGCTGAAAATATGCCACATGCACAATTGCGAACAGAAGATCCAACACTCTTTGAACTTCCACCGCTAACCACCGACGGTATTCCAACACCGGTTAAAATGAAGCGCAAGCGAAAGGCAAAATTGCGAATACGAACAGAAGATCCAACACTCTTTAAACTTCCACCTCTAATCGTCGAAGGAGTTCCAACACCGGTTGAAGAGATGGCGCAATACCAATTGCGAGCGTTTATACCGCAGATATTGAAATGTTCCATGGGTGTGGGCAAACCCGGTTGGGGAAAGGAATCGAGACGTCCACCTTGGTGGCCGAAAGAGGTGCCTTGGGATAATGTGAGAACTGATCATCGTACAGAGGAAGAGAAACAAAAGATGCGCTGGACACATGCTTTGCGCAAAATTGTCATTGACTGTTACAAATATCATGGACGGGAAGACCTTCTCTGGCCGAAGAAAGGCCACAAAAACGTAGTTGTTCAAACAAAAGAGGGAACATCGACGTCTTCTGTATCAGAAAGAACAAGGACTAACCACAACTATACGCCAGCAGTTCTATCCACAATCGAAAATGCTGATGGAACAGTTTCTCTGATGCAAGTGGATCCCAATAATCCAATCATCAAATTGCCAGATGGCACGAAGGCTCGAGTTCAAGGCGTCGCAACGCTTCATAAAGGCAAACGCGGTGTCTCCATTCAAACGGCTCAAAGTCTCTCAGATGTTGAACAAAACTATCCAGTTTCCGCCAGCAACGTGATTACAATGCCAGTCTCAGAATCCATGTACGAGTCAATGCTGGCCAACATCCAGCAATTGTGGCCAGACCATGTGCATAACTCCAATGCAGCCTTGGATAACTCGAATGGCGGCGCTGCACTTAATGTTGCTAAACACCTGTTAACGCCAGTGGCTATCATATTCAAACAGTTCCAACTCCAGGTTGCCACACAGGTAACACTAGCCTGTGAAGGACAAACATGCAAAGCACACAAGATGGTCCTATCAGCATGTAGTCCCTACTTTAAAGCACTCCTAGAGGAAAATCCTTCAAAACATCCGATAATAATCCTCAAAGATGTTTCCTACATTCATCTACAGGCGATTCTAGAATTTATGTACGCCGGCGAAGTGAACGTGTCACAAGAACAACTACCAGCCTTCTTGAAAACAGCTGATAGGCTAAAAGTGAAAGGACTAGCCGAAACACCTTCGTCTATTAAACGGGAAGGTTGA
- Protein Sequence
- MEELETVLTKQAPPTPTEDAKLFELPTVFIGGIRTPVEKKPKLQAQLRALTPTEDPTVFELPPLNIDGTQAPAENMPHAQLRTEDPTLFELPPLTTDGIPTPVKMKRKRKAKLRIRTEDPTLFKLPPLIVEGVPTPVEEMAQYQLRAFIPQILKCSMGVGKPGWGKESRRPPWWPKEVPWDNVRTDHRTEEEKQKMRWTHALRKIVIDCYKYHGREDLLWPKKGHKNVVVQTKEGTSTSSVSERTRTNHNYTPAVLSTIENADGTVSLMQVDPNNPIIKLPDGTKARVQGVATLHKGKRGVSIQTAQSLSDVEQNYPVSASNVITMPVSESMYESMLANIQQLWPDHVHNSNAALDNSNGGAALNVAKHLLTPVAIIFKQFQLQVATQVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADRLKVKGLAETPSSIKREG
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01044816;
- 90% Identity
- iTF_01044816;
- 80% Identity
- iTF_01044816;