Basic Information

Insect: Nematopogon swammerdamellus
Gene Symbol: NR2E3
Assembly: GCA_946902865.1
Location: CAMPPV010000404.1:108628-113605[-]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 3.1e-06 0.018 15.8 0.0 74 112 158 196 118 198 0.75

2 5 6.6e-07 0.0038 18.0 0.0 86 115 195 224 194 252 0.85

3 5 3.9e-08 0.00022 22.0 0.0 78 116 252 290 232 314 0.78

4 5 3.5e-06 0.02 15.6 0.0 90 118 315 347 307 381 0.82

5 5 8.7e-33 4.9e-29 102.5 0.1 84 195 387 496 371 497 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	3.1e-06	0.018	15.8	0.0	74	112	158	196	118	198	0.75
2	5	6.6e-07	0.0038	18.0	0.0	86	115	195	224	194	252	0.85
3	5	3.9e-08	0.00022	22.0	0.0	78	116	252	290	232	314	0.78
4	5	3.5e-06	0.02	15.6	0.0	90	118	315	347	307	381	0.82
5	5	8.7e-33	4.9e-29	102.5	0.1	84	195	387	496	371	497	0.96

Sequence Information

Coding Sequence: ATGCTCAACGACATATTAAAAAGATCACTCGTATCAGCCGGCTTTCCCTCAACTCTGGAGCCAGTGGGCCTATTCCGGGACGATGGTAAGCGTCCAGATGGCATGACCATCATCCCGTGGCGTGAGGGAAAGTCACTGGTGTGGGATGCTACCTGCGCCGATACTCTGTGCAGCAGTCACGTTAAGGCATGCTCGAAGCGCGCCGGCGCAGCCGCTGAAACTGCAGCCCGCCACAAGCACACCAAATACAGTTCGGTGGCACACCAGCACATCTTCGCCGCATTTTCGGTGGAGACGATGGGGGCATGGTCTGAGGAGGCAAAGCGGCTCGCGAAAGACATCGGGATGTCCCTGTACGCTGCTTCAGGAGAACAACGTTCGCTCGAGTTCCTGAGGCAGCGTATCAGTGTGGCCATCCAGCGAGGCAACGCCGCTAGCGTCCTCGGTACAGTGCCCACATCGTCACACCTGGAGGAGGAGCAAGGTCCTCACTCGTCACTGCTGCGGAGACTGCGCGAGGTGTTGTCCCGCTACCGCGCCGTGCTCGTCGATCCTGCGGAGTTCGCCTGCATGAAGGCTATAAGACTGCGCGAGGTGTTGTCCCGCTACCGCGCCGTCCTCGTCGACCCTGCGGAGTTCACCTGCATGAAGGCTATCGTCCTCTTCAAGTCAGGTAACTGCCGGCTCTCGTGGACCCCTGGCACCAGAGCGTGCTCCTCACTCGTCGCTGCTGCGGAGACTGCGCGAGAGCGAGCCCCTCACTCGTCGCTGCTACGGAGACTGCGCGAGGTGTTGTCCCGCTACCGCGCCGTGCTCGTCGCCCCTGCGGAGTTCGCCTGCATGAAGGCTATAGTCCTCTTCAAGTCAGGTAACTGCCGGCTCTCGTGGACCCCTGGCTGGATAGCGAGCTCCTCACTCGTCGCTGCTACGGAGACTGCGCGAGTGTTTTCACGCTACCGCGCCGTGCTCGTCAACCCTGCGGAGTTCGCCTGCATGAAGGCTATAGTCCTCTTCAAGTCAAGTAACTGCCGGCTCTCGTGGACCCCTGGCTGCAGAGCGAGTTCCTCACTCGTCGCTGCTACGGAGACTGCGCGAGGTGTTGTCCCGCTACCGCGCCGTGCTCGTCGACCCTGCGGACGAGCTCCTCACTCACCGCTGCTACGGAGACTGCGCGAGGTGTTGTCCCGCTACCGCGCCGTGCTCGTCGACCCTGCGGAGTTCGCCTGCATGAAGGCTATAGTCCTCTTCAAGTCAGAAACGCGCGGTCTGAAGGACCCGCTGCAAATCGAGAACTTGCAAGATCAAGCTCAAGTAATGCTGATGACGCACGCCCGCACCAGCCACAGCGCCGCGCCTGCGCGCTTCGGTAGACTCCTCCTGCTGTTGCCGCTGCTCCGCCACGCGCCACCGCACCAGGTCGAGCTGGCGTTCTTCGCCAGAACCATCGGCCAGACTCCTATGGAGAAGGTCCTTGCCGATATGTACAAGAACTAG
Protein Sequence: MLNDILKRSLVSAGFPSTLEPVGLFRDDGKRPDGMTIIPWREGKSLVWDATCADTLCSSHVKACSKRAGAAAETAARHKHTKYSSVAHQHIFAAFSVETMGAWSEEAKRLAKDIGMSLYAASGEQRSLEFLRQRISVAIQRGNAASVLGTVPTSSHLEEEQGPHSSLLRRLREVLSRYRAVLVDPAEFACMKAIRLREVLSRYRAVLVDPAEFTCMKAIVLFKSGNCRLSWTPGTRACSSLVAAAETARERAPHSSLLRRLREVLSRYRAVLVAPAEFACMKAIVLFKSGNCRLSWTPGWIASSSLVAATETARVFSRYRAVLVNPAEFACMKAIVLFKSSNCRLSWTPGCRASSSLVAATETARGVVPLPRRARRPCGRAPHSPLLRRLREVLSRYRAVLVDPAEFACMKAIVLFKSETRGLKDPLQIENLQDQAQVMLMTHARTSHSAAPARFGRLLLLLPLLRHAPPHQVELAFFARTIGQTPMEKVLADMYKN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01042757;
90% Identity: iTF_01042757;
80% Identity: iTF_01042757;