Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.021 1.5 10.0 0.2 3 17 164 178 163 179 0.90

2 6 5.4e-05 0.0038 18.2 2.6 1 23 204 227 204 227 0.97

3 6 8.8e-06 0.00061 20.7 0.5 1 22 233 254 233 257 0.90

4 6 0.00019 0.013 16.5 3.0 2 23 270 291 270 291 0.97

5 6 0.00091 0.063 14.3 1.2 1 23 297 320 297 320 0.97

6 6 1.4e-05 0.00095 20.0 0.8 2 23 326 348 326 348 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.021	1.5	10.0	0.2	3	17	164	178	163	179	0.90
2	6	5.4e-05	0.0038	18.2	2.6	1	23	204	227	204	227	0.97
3	6	8.8e-06	0.00061	20.7	0.5	1	22	233	254	233	257	0.90
4	6	0.00019	0.013	16.5	3.0	2	23	270	291	270	291	0.97
5	6	0.00091	0.063	14.3	1.2	1	23	297	320	297	320	0.97
6	6	1.4e-05	0.00095	20.0	0.8	2	23	326	348	326	348	0.96

Coding Sequence: atgaatataatagaGATTATGCAAACAATACTTGATGAAGAAATATCTGCTGAAAGTTgctgtttttgtttaaaaagatCTGAAAATCTAATAGATGTTTTTCAAAACTGTGAAGTTATTGATGAAAATGGTTCATATACATTTACCATACTGGATGCAATTAACAAAATGGCTCTTTTTGATCTCTCCAATGCTGTTTCTAACAATATTTGTGAAGAATGCTCAACACTGATTCTACaactttatattaaattaagaaaACATCAACACACAAAGGAGTTCATGCTTCAACTagtcaatattttattcaatcaAACAGATACTAATCAAATATCAATTGATggtatgtttaaattatatgttCCTAAATTGAAAGTTACAGTTGATACAGTTAGAGATTTGAATTTTTGTGACAAAGGATATTTTgaacatttaaatattaatgcaCAAACAAATGAGACAAACACAAAACTTAAAACAGATAACATTTGTCACAAATGTGGAAAAGTATATGAAACTCTTCATAAATTGAATTTAAGGAGCAAAAAGGCAAGATGTCCTTGTTTGAATGTAGTGAAAAATcagaaaaaatacataaaaaatacgaaaTATACATGCAACGATTGCAATTTCAGTAgcaaaaacaaatatacattAGAAGCTCATATACATAAAGTTCATCTTAACATTAGGCCGTATAAGTGTGGCATATGTGATAAAGGATTTTACAAGAAAAGCAATCTAGTCGAACACAAAACAACCATTGCCCATTTAAAGAAGTCTAATACAGCGCGGCAAAAAGATAACACATGTGATATTTGCGGTATCCATTTTGTGAATAGAAAATGTTTAAGAGATCATTTGAGAGGTCATTATAATGAAAAACCTTACAAATGTGAAAAATGTGATTTAACATTTGTCTCGGCAAGTAGAAGATCTGATCACGTTAGGAGGAAGCATAATGAGAAGACGGAGACTTGTCAGTTTTGTGGGAAAGTGTTTAATGTAAAAAGTGTATTGAATAGACATATTAAAAATCTGCATAAACAGTCTGTATGA
Protein Sequence: MNIIEIMQTILDEEISAESCCFCLKRSENLIDVFQNCEVIDENGSYTFTILDAINKMALFDLSNAVSNNICEECSTLILQLYIKLRKHQHTKEFMLQLVNILFNQTDTNQISIDGMFKLYVPKLKVTVDTVRDLNFCDKGYFEHLNINAQTNETNTKLKTDNICHKCGKVYETLHKLNLRSKKARCPCLNVVKNQKKYIKNTKYTCNDCNFSSKNKYTLEAHIHKVHLNIRPYKCGICDKGFYKKSNLVEHKTTIAHLKKSNTARQKDNTCDICGIHFVNRKCLRDHLRGHYNEKPYKCEKCDLTFVSASRRSDHVRRKHNEKTETCQFCGKVFNVKSVLNRHIKNLHKQSV

Sequence clustering based on sequence similarity using MMseqs2