Basic Information

Gene Symbol
-
Assembly
GCA_009193385.2
Location
NW:49383-53183[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.028 2.3 8.3 0.1 2 23 126 147 125 147 0.91
2 18 0.16 14 5.9 7.8 1 23 168 190 168 190 0.97
3 18 1.3e-05 0.0011 18.8 1.7 1 23 205 227 205 227 0.99
4 18 0.0053 0.45 10.6 0.5 1 23 233 255 233 255 0.97
5 18 0.00016 0.013 15.4 0.6 1 23 261 283 261 283 0.97
6 18 0.00024 0.02 14.9 7.9 1 23 294 316 294 316 0.97
7 18 3.4e-07 2.8e-05 23.8 2.0 1 23 325 347 325 347 0.98
8 18 3e-06 0.00025 20.8 1.1 1 23 353 375 353 375 0.98
9 18 6.4e-06 0.00054 19.8 5.9 1 23 381 403 381 403 0.98
10 18 0.0087 0.73 9.9 7.0 3 23 404 424 404 424 0.94
11 18 0.0083 0.7 10.0 1.0 1 23 501 524 501 524 0.96
12 18 0.029 2.4 8.3 4.6 1 23 534 557 534 557 0.94
13 18 0.033 2.7 8.1 1.5 1 23 562 584 562 584 0.97
14 18 1.4e-05 0.0012 18.7 0.2 2 23 591 612 590 612 0.97
15 18 0.0021 0.18 11.9 0.1 1 23 618 640 618 640 0.96
16 18 0.12 10 6.3 0.5 1 23 649 671 649 671 0.97
17 18 8e-05 0.0067 16.3 0.8 1 23 699 721 699 721 0.96
18 18 4.2e-05 0.0035 17.2 3.6 1 20 727 746 727 748 0.95

Sequence Information

Coding Sequence
ATGGTTACGGATCATGGTGTTGAACGACTCATGGTTACGGATCATGGTGTTGAACTCTTCCAAGTCATTCCAGAAAAAAGTTTACAAGTCACTTGGTTTATATTTTGTCCACAAAGCTACATGGTCTTGCTTTCATCAGGAACATTAAGAAATCAAATGCAGCCATTGTACATTACTCCAGGGAATTTGCACAAGAGGTTACTGATGTTAATGTTGTCAAAAGGGACGGCGGAGCCGTCCTCGACCCAAGTCTTCTGCAGTGCCGAGGACCAGACGTCCCTGCTCATGGCTGCTGCGCAGTCCCTTGAGGCCGACGACGACAACACAAAGGTCGAGAACAACGGCATCGTCTTGGTACCGCCGGAGACCCTCCTCCAGTGCACCCTCTGCGGTGAGGCCTTCGTCGACGAGGCCTATTTCGACTTCCATCTCAAGAGCCATGACGTAGAGTCACCTGTTCACCATCAGGACGCTAATTTGGTCGAGGAGACTGTATTGGTCTACGCCTGCGATCACTGCGAATGCACCTGTGCCGACGAGGACTCCTTCCACAAGCATCGCCTCAGTCACGAGGACGATGAGCCCCTGCAGGTTGTCGTTGGGGAGAAGCTCTACACCTGCGAACTGTGTGGCTACAGTAGTGCCCACAGACAAAACCTCGCCAGTCACCAGCGCCGGCACAATCTAGAGTACAAGTACCATTGCGAGATTTGCGGCGCTGGTTTCTACGCGCGCAATACCTACCAAGAGCATCTGTCCGTTCACTCTCGGGAGAAACCCTTCCAGTGCGACATCTGCCAGGCGACGTTCCGCTATCGTCAAGGTTTGAGGCTACACGCGAAGCTCCACCAACCGGACTATGTGCGAGCCCAAAAGAAGCACTGCTGCGAGGTCTGCAACAAGCGTTTCTGCCGCAAGCAGGTTCTACTTGTACACATGCGCACCCACGGCAGCGCTGTACCGCAGAGCGAGTTCGTCTGTCACATCTGCGGTAAATCCGTCTCAAGTAAAACCTATCTCACGGTCCATCTGAGAAAGCACACTGGCGAGAAGCCCCACGTTTGCGATCTATGCGGAAAAGGATTTATATCCCAGAACTACTTGAGCGTGCACCGACGTACTCATACCGGTGAGCGACCTCACAAGTGTACTCATTGTGAAAAGAGTTTCACGCAGAGGACGACGTTGGTGGTGCATTTGAGAAGTCACTGTACTTGCTGTCACAAGAGCTTTGCCTCGAAGACAATGTTGAACTCGCATTTAAAGACTCACGCTAAGCAGACCGCCAGGGCGCAACAAGAGCAGCGCACGCAGCTgcacctgcagcagcagaatCTCTTGCTGTCGCCAGAGGAAGAAGCGCTTagagaacagcagcagcctgTCGAGCCGGATAGTAGTAGTACAGGGCTTTACGAGTACCTCGAAAACGAGGAACAACTTACCGAGCCCATACGCAGTCTCCTCGTTCGCATGGACTCCGGGGCGTTGAAGCGACTATACCAGTGCAGTCAGTGCGAACAGGTGTTCGCCACGGTAAAGCTCTGTGTGCGACACATGTCGGTGGAACATCCCCGTGGACGCAAGTACCGCGTGGCATACCGCTGCAAGACCTGCCAGAAGCTCTTCCGCACCAAGTATGGCTGCGAAAATCACATCCAGGGCAAACACAAGCATCGGACTTTTGAGTGCCGTTACTGCGGCTTCAAAACCGCCAGCATCACCTACATCAAGAAGCACGAGAGAAACCACGTGGACGACTTCGAGATTCGTTGTGACGTATGTAATAAAGGTTTCGCCTCTAAGAACGTTCTCGAGAGGCACATGATCAGTCACACGGGCGAGAAGCCGTTCGTCTGTAAGGAGTGTAACTCCGCTTATGCTGACAAGAGAAGCTTGATGCTCCACGCGACGGTGCACAATCCCGAGGGTAGGCCGAAAAAGTACACCTGCGAGGTGTGCGAGTACTCGAGCTTCTGGAAGAACGCGGTTAAGACGCATATGAAAGTACACACGGGTGCCAAGGTCATCTGCGATGAGTGCGGACAGGCCATGGCAAGTAACTACTATCCATTTCACTCGGATGAAAAGCCGTATACCTGTGACACTTGCAATAAAGGCTTTAGGCAGATGAAAAATCTTGTGGTGCATCCGAGGACACATAGCAAGCTCAAGCCGTATAAGTGTGACACTTGCCAGAAAAGCTTCTCCCAGAACGTTTGGCTGAAAAAACACAAGTGTAATCCTGCGTAG
Protein Sequence
MVTDHGVERLMVTDHGVELFQVIPEKSLQVTWFIFCPQSYMVLLSSGTLRNQMQPLYITPGNLHKRLLMLMLSKGTAEPSSTQVFCSAEDQTSLLMAAAQSLEADDDNTKVENNGIVLVPPETLLQCTLCGEAFVDEAYFDFHLKSHDVESPVHHQDANLVEETVLVYACDHCECTCADEDSFHKHRLSHEDDEPLQVVVGEKLYTCELCGYSSAHRQNLASHQRRHNLEYKYHCEICGAGFYARNTYQEHLSVHSREKPFQCDICQATFRYRQGLRLHAKLHQPDYVRAQKKHCCEVCNKRFCRKQVLLVHMRTHGSAVPQSEFVCHICGKSVSSKTYLTVHLRKHTGEKPHVCDLCGKGFISQNYLSVHRRTHTGERPHKCTHCEKSFTQRTTLVVHLRSHCTCCHKSFASKTMLNSHLKTHAKQTARAQQEQRTQLHLQQQNLLLSPEEEALREQQQPVEPDSSSTGLYEYLENEEQLTEPIRSLLVRMDSGALKRLYQCSQCEQVFATVKLCVRHMSVEHPRGRKYRVAYRCKTCQKLFRTKYGCENHIQGKHKHRTFECRYCGFKTASITYIKKHERNHVDDFEIRCDVCNKGFASKNVLERHMISHTGEKPFVCKECNSAYADKRSLMLHATVHNPEGRPKKYTCEVCEYSSFWKNAVKTHMKVHTGAKVICDECGQAMASNYYPFHSDEKPYTCDTCNKGFRQMKNLVVHPRTHSKLKPYKCDTCQKSFSQNVWLKKHKCNPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-