Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 5e-05 0.0048 18.3 1.7 1 23 66 89 66 89 0.94

2 7 0.00029 0.028 15.9 0.3 2 23 97 119 97 119 0.96

3 7 0.0037 0.35 12.4 0.3 1 22 123 144 123 144 0.93

4 7 2e-05 0.0019 19.6 0.5 2 23 151 173 150 173 0.95

5 7 0.0091 0.86 11.2 1.4 3 23 181 202 181 202 0.95

6 7 0.0019 0.18 13.4 0.6 3 23 209 230 207 230 0.93

7 7 0.0027 0.25 12.9 5.7 2 23 236 258 236 258 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	5e-05	0.0048	18.3	1.7	1	23	66	89	66	89	0.94
2	7	0.00029	0.028	15.9	0.3	2	23	97	119	97	119	0.96
3	7	0.0037	0.35	12.4	0.3	1	22	123	144	123	144	0.93
4	7	2e-05	0.0019	19.6	0.5	2	23	151	173	150	173	0.95
5	7	0.0091	0.86	11.2	1.4	3	23	181	202	181	202	0.95
6	7	0.0019	0.18	13.4	0.6	3	23	209	230	207	230	0.93
7	7	0.0027	0.25	12.9	5.7	2	23	236	258	236	258	0.96

Coding Sequence: atgaGCAAATATTTCCCAAAACCTGAAATCGACGTAAATATAGAACGCTTGGACTCGGATATCATCGACGAACACCTCCGTAACTCCACAGCCGTGCTACAAGATATCTTGAAAGACAAGGAAGACTCCAACAACTGCTACGCCGACTGCGAAGCGCCCTCTGACGGTGAGGAAGCCGACGGCAATAGTGATGGTCATGTATGCCAACTGTGTGGGAAGATCTACAAAACGGCTAGTACGTTACACGCTCACTACCTGCTCATGCACCCTGAGAACGAGGTAGAGGGGCAATGTGTGGAGTGCGATAAGAAGTATCCATCAATCCTGAGCTTACAAAAGCATATACGATACATGCACCGATATGGTCATCGCTGTAAAGCTTGCTATAGAACGTTTGCAACGCCAGAACTGTTGGAGTTACACGGTAAAACTTGTAGCAAGACTGAGACGCCTTGTTCCCAGTGTGGTAAGGTATTTGATTCCCGCCTCGCTCTACGAAACCACATAAAATATAAGCATCCAGAGAGGAGGAATCATTGGTGCGAGCTGTGTCGGCGAGCATTCACGACTCATCGTGGTTTGATGAACCACAACGCAACGATACACCCCCCGGGAGCAACTAACTGCAACTGGTGTAAGAAGATCTTCAACTCGGTGACAGCACTTCAAAGTCACGTGCTTTATAAGCATACAGAAGATGGAGCCAAATGTGCTCAGTGCCACAAAGTGTTCGCAAAGAAGATTTGTTTACAGaaacatttagaaaaaaaacatcagtATTACGTAGCCACTTGTGTAACTGTAAACGATTCTGAAACTGGGACTTCTACTGAGTCAAATTAG
Protein Sequence: MSKYFPKPEIDVNIERLDSDIIDEHLRNSTAVLQDILKDKEDSNNCYADCEAPSDGEEADGNSDGHVCQLCGKIYKTASTLHAHYLLMHPENEVEGQCVECDKKYPSILSLQKHIRYMHRYGHRCKACYRTFATPELLELHGKTCSKTETPCSQCGKVFDSRLALRNHIKYKHPERRNHWCELCRRAFTTHRGLMNHNATIHPPGATNCNWCKKIFNSVTALQSHVLYKHTEDGAKCAQCHKVFAKKICLQKHLEKKHQYYVATCVTVNDSETGTSTESN

Sequence clustering based on sequence similarity using MMseqs2