Basic Information

Gene Symbol
topi
Assembly
GCA_943737955.2
Location
OX031314.1:57994999-57998041[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 4.6e-05 0.0059 18.1 2.6 1 23 260 282 260 282 0.97
2 10 0.0034 0.45 12.2 0.9 2 23 319 340 318 340 0.97
3 10 0.0032 0.42 12.3 0.1 2 19 403 420 402 422 0.95
4 10 0.1 14 7.5 1.6 1 22 471 492 471 495 0.90
5 10 0.37 48 5.8 0.6 2 22 510 530 509 532 0.82
6 10 5.7e-07 7.4e-05 24.1 1.9 1 23 552 574 552 574 0.95
7 10 0.0034 0.44 12.2 1.1 1 23 580 605 580 605 0.95
8 10 0.5 64 5.4 1.7 1 23 611 633 611 633 0.88
9 10 4.3e-08 5.5e-06 27.6 0.4 1 23 639 661 639 661 0.99
10 10 0.048 6.3 8.6 1.4 3 23 669 690 667 690 0.95

Sequence Information

Coding Sequence
atgaattcCTCCAATCTGGTAAATGTCGAGGAATTTCCTAATTCTTTATGGCTCTCTGAACAGCTATTTTCGCAATTAAGAGACTTCGACTCCGTTGATTACAAAGAAAACGGGAAAGAGATTGTTATATCAGAGGAAACCGAAACAACACGTCTTGAAAATTTTGAATCGGTGTTTAAGCGGAATGGACTTGAGACTACTGAAGAACTCAATAATTCCACGGAGAAAGAATGTAGTGTAGAAGCAGCAGTATTATTGGACTTGGGAACTACTGGAATCCCTGTCGCGTTAGAAGCAGAGCTATCAACGAAATCGATGATCCTTGGTGGAACCGAAGAAGAAATGAAGCTGTTAAGATATTTAGAATCTCAATCAAATCACACTTATTTTGATACAAAGTTTTGCATGCAATCGGAGCTGCCTTCTACCGCATATCGCATTGTCAAATGTTCCAATTGTAATTGCCTATTCGATATCATATCCTTTCAGTCTCATGTCTGTGATTACGATGAGCATCACAATTTAATTATGCCGCCCCTGACATCTACAACAATCAGTATTAAGCAACCGAAGAAAGAGCCACTATTACCAGCTGAGCCCGCTTGTATGAGATTGCTCCGTGAGAATCAGATACGCATACGTCGATTTCTGAAGGATGAGCTTAAGTACGATGTGAATGCATCTATCAATAATACCGGCTCTAACAATGGGAATAATTTATCTATGACGTCAGGGAAATCAAATTCTTCcaattgcaataaaaagcaATATGGTCCACATGAATGTACGCTATGTGAACGTAAGTTTGTGCATGCTTCCGGACTTTTGCGTCACATGGAGAAGCATGCAATGGATTTGATACCGACACCTGGAGTTGGGTCATCAGGAGGTAAAGCATCTGCCGCGATTGCAGGTAACTCATTTCAGAATGCGAATGGATTGCGTGTAGTGATCAAGTGCACACTCTGCGGTCGTATATTTTTTGAGCCCTCGGCAGCTTACAAGCATTTGTGTACACATTTTCCTGGAAGTTTCGAAGAAGAAAATGAGATGGACAATTCAGCCGAAATTCCTTATGAGAGCTATGTAGATGACGCTTTGATCACCATTACAATAGAGGATAAAACAACCAACTACATATTTTCACCATACCACGAAGATAAGTCAcctatgtatttaaaaatggtGATCCTTAGTTGCATCTTGCAATGCGAGTTTTGTGATTACGTTTTCTCCGATGtctcttatttgtttgtgcaTTCAGCTTGTCATTTGCCTGAGCGTCGCTTTGAATGCTTCTCTTGCAACATACACATGCGCACTTCTAAAGAGATTTGCACCCACTGGCAGGCGGAATGCGTATTTATGCGCGAAAATCTAAAGGTTCATCAGGCAACAACGCAACGCTATTTCGTTTGCAATGTTtgtgaaaataaatttcaatccATGGATCAATTACATGAACACCGCTACACTGCATATCACTTCTTTCCACGCTTGCATAAGGCCATTGGATTATTGCATATACCCTGTGAATACTGCGATTTGGTATTTGAACATGCACAGGAATGTGTGGCTCACTACGAAGAGaaacattacaaaaaatacaaacgaGATAAGGACGGCATTGGATCATCGTGCAAGACACGTCAATATTTATGTGACATCTGTGGGAAATCTTACACACAATCCAGCCACTTGTGGCAACATTTACGATTTCACCAAGGAGTAAAGCCGTTTGCCTGTAAGGAACCTGGCTGTACACGCAAATTCACCATACGTCCTGACCTCAATGACCACATACGCAAGTGTCATACCGGAGAGCGCCCTTACCACTGCCTCGTATGTGGCAAACGCTTTCTGACTGGTTCTGTTTTCTATCAGCATCGTTTAATTCATCGTGGAGAACGTCGTTACGAATGCGAAGAGTGTGGTAAACGTTTCTATCGTGCCGATGCATTAAAAAATCATCAACGAATACACACTGGAGAAAAACCTTTCGGATGTCTTTTCTGCACTAAAAACTTCCGCCAGCGCGGAGATCGCGATAAGCATATTCGAGCTCGTCATTCCCACTTGGATGCAAATTCACGTCTAATGATGCAAATGCAGAAATTGCAACTAgaggctgctgctgctgcagccgCAGCACAAGTTCAGGCTCAACAAAGAAATGCTTTGGATAATGTTGGTATCCCACGTAACATTGATAGGCAACATTTGGATCCCAATGATATGGTAATGATAGGCAATGTTGCTTTTCCGAAGAGTATGTTTGGATCAGTAATTCCAGATTTTGATGAAGAGGCTGCATTGAAGGCCATGCATGTAAATGCCTCAAATTAA
Protein Sequence
MNSSNLVNVEEFPNSLWLSEQLFSQLRDFDSVDYKENGKEIVISEETETTRLENFESVFKRNGLETTEELNNSTEKECSVEAAVLLDLGTTGIPVALEAELSTKSMILGGTEEEMKLLRYLESQSNHTYFDTKFCMQSELPSTAYRIVKCSNCNCLFDIISFQSHVCDYDEHHNLIMPPLTSTTISIKQPKKEPLLPAEPACMRLLRENQIRIRRFLKDELKYDVNASINNTGSNNGNNLSMTSGKSNSSNCNKKQYGPHECTLCERKFVHASGLLRHMEKHAMDLIPTPGVGSSGGKASAAIAGNSFQNANGLRVVIKCTLCGRIFFEPSAAYKHLCTHFPGSFEEENEMDNSAEIPYESYVDDALITITIEDKTTNYIFSPYHEDKSPMYLKMVILSCILQCEFCDYVFSDVSYLFVHSACHLPERRFECFSCNIHMRTSKEICTHWQAECVFMRENLKVHQATTQRYFVCNVCENKFQSMDQLHEHRYTAYHFFPRLHKAIGLLHIPCEYCDLVFEHAQECVAHYEEKHYKKYKRDKDGIGSSCKTRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFACKEPGCTRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFGCLFCTKNFRQRGDRDKHIRARHSHLDANSRLMMQMQKLQLEAAAAAAAAQVQAQQRNALDNVGIPRNIDRQHLDPNDMVMIGNVAFPKSMFGSVIPDFDEEAALKAMHVNASN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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