Basic Information

Gene Symbol
ZNF526
Assembly
GCA_034621355.1
Location
CM067898.1:15789462-15813190[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 8.3 5.7e+02 2.0 2.9 1 19 491 509 491 513 0.82
2 16 0.00062 0.042 15.0 0.0 1 23 523 546 523 546 0.95
3 16 0.049 3.4 9.0 3.8 2 23 711 732 710 732 0.95
4 16 4.5 3.1e+02 2.8 1.3 1 23 744 768 744 768 0.90
5 16 0.00022 0.015 16.4 0.6 2 23 775 798 774 798 0.96
6 16 0.097 6.7 8.1 0.2 1 23 804 826 804 826 0.93
7 16 0.003 0.21 12.8 3.3 1 23 832 854 832 854 0.98
8 16 1.5 1e+02 4.4 0.0 2 19 865 882 864 885 0.88
9 16 0.065 4.5 8.6 0.2 1 23 962 984 962 984 0.97
10 16 2.9 2e+02 3.5 7.2 1 23 991 1013 991 1013 0.95
11 16 0.0088 0.61 11.4 2.4 1 23 1048 1071 1048 1071 0.95
12 16 0.0068 0.47 11.7 1.2 1 23 1078 1101 1078 1101 0.97
13 16 0.021 1.4 10.2 0.1 2 23 1123 1145 1122 1145 0.95
14 16 0.0071 0.49 11.7 0.4 1 23 1200 1222 1200 1222 0.97
15 16 0.00031 0.022 15.9 0.1 1 23 1228 1250 1228 1250 0.97
16 16 0.00033 0.023 15.8 2.6 3 23 1258 1279 1258 1279 0.97

Sequence Information

Coding Sequence
ATGGTGGAACCTGAGCCTTTGATTCTTTGCATGGAGAATATGAATGGTGAAGAAGTGGAATTAAAGATTGAACTGCACGACACTTTCCAGGATTTTCTGGAGAAAGCCAAACTCCTTCTAGGCTATGATGTAGATATAAATTCTATAACTGGAAACCAACCAGTATCTTTAGACGCAAACATATACAATTTTCTATTAAAAGCAGAACAGCATTTTAAAGGTACTACTCTCAGTCCagaaaattttgatgaaatgagCGAACATAATGAAACGGATGATCTAGTTTACATTCTTGATGATGGCACTCAAATACGTGCTTCACAAATACaatttgataatgatgatcctgTTGTGGACTTAACGTCTGAACAAATACCATTTGTTAAATACAAAGACGATAGCAACGAGGAAAATGATGAAATTGACGATACAAAtgtaactattaaaaatatcaacataAAAGACAGTCCAGTAGCCAGTTGGAGTAATAAGGAAAGTCCTAAATGCAGTTTCGCGAATAGTCTACCATTCAACCTTGTTTGCAACAACATATTGAATTTTGAAGCACAGTTTACAAAATACCTCGAATCTAGTGCAAAAACGTACACCGATTtgaataacataacaaaaaataaatcgcCAGGAAGTGCTATAggggaaaattataaaaattatgatagcAAGAATGATGGATTTTTTACAAGGGAGGAtgtattgaatatgtttaaagaCGCTCCAGTGACTCCTTTACCTTACGAAGATAACCAAACAGAGAAACGTAAGCACGTGAGAAAAACAGATCCAGCTAGAGTAGTGTATAAAAACTGGAACGCCAAACCTATTACTGAAGTAGGATCAGGTTTAGAGAAGCAAAACTGTTTCATTTGCTGTGAAATCGTGAAAAATAGTGAAAAGTTATACTTATTTGATAAGGAAGATCAGATGTTGCATCGTTGTGAACAAAGAAAATACAACATGCAATTAAAAATCATATGCGATAAATGTCTTAGTGAAAACTTCAAGCCTTCAAGAATAAAAAGTCCAACTCAGTCGTTAGATGACAATGAATATttggtaataaaaaacaatcagCAATTCATATTCCAAAAATCTAGTAACATTAATCTGAAgagtagttattttattaataacataaatatgaaTAACATAAACAACACAGAAAAagtagataaaattaataaaacaacaagAAATAGAGAAAGTGTTGAGTTTGTGAAGGTTGAAATTGGACCGGATGGAGAAATAGTTACCAAACCTATAGACAATGATGTTAAATATGATGACGTAGTTATTGTTAAGGATAAAaaggaTAGCTCCAGCGACGTAGAGATTATAGAACCAGATGTGAACGAACAAGATGTTGAAATAGATGTAGACAATTTTGAAGACGCGGATGAACATGTAAAGGAATTTTTGGGAAAGTACCAGcgcaattttgaaaatacagAATTCAAATGcaggttttgtaaaaaaaattttgaaaagctggAGCAAGCTGTAGAGCACTGTGATGTACACAAGCACGAGCTTGACGATGGTATTGTCTTCCCATGCCCGCTGTGTGATTACGGGTACGAAAATTCAAAATGGCTGAAAGCACACTTGAATGCGGCACATGACAACATGAACAAAGACAAGTCGACAGAAGAAAACACGATCAAAGAAGAAAACAGCCAAAACAAAGAGGACGATgcagataaaattataaataattCCGAAGATGTGAAAGATTTGCATTCACCTGTCGCCAAAAGAACCAGGAGTTCACTTAAGAAAAATGAAGAAGATATTATCaatggtACACCAGAGACACTGCAGTCAAAAGAATCTGAGTCCCCAATGGTAGatctacaaaatacaaatattaatattaaggttGAGGTGAAACAAGAAGATAGTAGCGACAGCGACTCCATATGGATAGTGCACACTGGCGACGATGATGACGAACAACTGAAGAAATTGTTACAGGTTACGGAAGCTAAACGAGATGTGAACGATTTAAAGAGACACAAATGTTTTACTTGCAGgtattattatgatataaaatcaaattttcttctaAAACGTAAAAAGAAAACTCGAGAACCAAACGATCCACAAATAGTAACTTGCCATAACTGCAACGAGTCCTTCACTTCTAAAGTGAGACTCAAGTTTCATATGCAATTCCACGAAGCAACAAACCTCCTAACATCAGACGGCCAGTACGTATGTGCGGATTGTAAGGATACAACGTTCCCTAATGAAACGAAGTTGTTCGACCACGTGCACTTCCAGCATAATAAGCAAAAGCGATGGCAGTGTCCCGTTAAAGATTGCGGGAAAACCTTCTTTTTGAGGGCAACATTAACAAAACACAGTCGCATGCACACAGACACACGGCGCTACGTGTGTGTGACTTGCGGCAAGAGGTTCCTCGACAAGCAGACGTTAGATGAACACGGAGTCACACATCTGCAGATCAAACCGTTTCAATGCCACATATGTCTGAAGCAACTGACGCGCAGATCTCGTTTGCGTATGCATCTGCGCGCGCACGAGGAGGAGTTGTCCCCGGCGCTGGTGCTCGTGTGTGCGATGTGCAGCAGGGCTTTCAGAGACCATGTAGATGCTCAGGAGCACGCAGCCAAATCAACCGAGTGTATAGACGAGTTTGCAAACGATCTCAAAGAGGAGGCCACTTCCACCGAGCAACTGTCACCCACCAGTGGGATTGTAAGACATACTGTGCTTGTTACAGAAACCCGCGGCAAAACATCTATACCTAAAGAAGTAAATACTGAAGAGAGTGAAACATTGTTGGCGGCTTTGGATGACGTCGCTAGGAATATTATACGCGTGGTAGATATCGAGAAGGCTTTCCGATGTGAATATTGCGAAGAtgtattttacttGGAGGATGCACTAAATAATCATAGATTGTTACACAAGGATGTGAAAAATCCTTTCACCTGTCACATTTGCAAAGTTAGCTTTGCTACTTACTCAAGGTGTACTACTCACAAAACGACGCACGGTTTCTATAAGcgcagcgccacggaggctagCACCGAGGGGCGCGCCGGCCCGGCCAGCGCTGGCATACTGGGCTATGGCGGCTTCCCTGTGGTTAAACACTTTCTGTGCGAGGATTGCGGTCGATCTTACTTGCATTGGACTTATTTCCAAGTGCATCGACGTATGAAACATGCGAATGAAAATTACATTTTCAAATGTAATCAGTGTGAAATGACTTTTCCTAACAGttGGAGTGCAACATATCACAGAAAAAAAGTTCACAGTAAAAATAGTCAAGACGCGAACGGCGGGTTTACGAAGATCGTTCGAGAAAATTACAGGATCCCATGTCGTGATTGTGATGAGGTGTTGCCAAACAAAATTGCACTCTATAAGCATCGGCAGAAGGAACATTGCGACGCTACTTTGATGGATAAAGAAGACGAGTGGTCAGAGCTAGAAGAGGCTGACACCACAGTGTGTAGCAAATGCGGTCTTGATCTACACAACGTTGTATCATTGGGACAACATGACAAAGACGTGCACGGCTGCTCTTCGGAGGTCCGCACAAGTGCGCACTCTTGCCCGGTGTGCGCGCGTAGTTTCCGCTCGGCGTCTATGCGCGACGAGCATGTTCGCGTGCATACAGGCGAGCGGCCATTTCCCTGTGACGTGTGCGGCGTGGCCTTCAGACGGTCGACGGCGATGCGCAACCACCGTCTGCTGCATACAGGCGCTCGTCCCTGGGGTTGCGCGCACTGCCCCAAACGATTTCGGGTCAAGTCTGATCTGAGGACACACGTGCGACTCAAGCATCCTGCGCATTTGGCCGTCATAGAGgttgAAGGAAGAAGCTGCACTCAAGAAGAGGTGTTGCAACATCTCGACAACAACAATATAAGCCGGGACAAAGTTATAGAAATTACCATGATCACTTTTCCTCAGAACACAACCAATATTGTGCCGAATACTGTTCGAGCTCTCTCTATGTTAAGCGATTTCCCGAGAACTGTGATTCCGTGTGATTGGAAGACGCGCGTCATTTCTCTTGGCCAATCTCAAGaaaCGCTCCAACCACCGCCTCGCCGTGGGCGAGGTATAGACAAGAATCCTCGCAGAGCCGCCATACTGCAGCGCTGCGACGATTTACCACAGACATCGCAAGACACCAGTACCTACGTGCAAAACGAGGGAGAGAATATACCAACTCTCGACGTACAGCTCCTACTGCAAAATGGCACGCTTCTCAACAAGAGTCAAGTTATACAAGTGAACGATGGAATATTGTTGGAACAAAGCACTACTAACACTGCTGAGTAG
Protein Sequence
MVEPEPLILCMENMNGEEVELKIELHDTFQDFLEKAKLLLGYDVDINSITGNQPVSLDANIYNFLLKAEQHFKGTTLSPENFDEMSEHNETDDLVYILDDGTQIRASQIQFDNDDPVVDLTSEQIPFVKYKDDSNEENDEIDDTNVTIKNINIKDSPVASWSNKESPKCSFANSLPFNLVCNNILNFEAQFTKYLESSAKTYTDLNNITKNKSPGSAIGENYKNYDSKNDGFFTREDVLNMFKDAPVTPLPYEDNQTEKRKHVRKTDPARVVYKNWNAKPITEVGSGLEKQNCFICCEIVKNSEKLYLFDKEDQMLHRCEQRKYNMQLKIICDKCLSENFKPSRIKSPTQSLDDNEYLVIKNNQQFIFQKSSNINLKSSYFINNINMNNINNTEKVDKINKTTRNRESVEFVKVEIGPDGEIVTKPIDNDVKYDDVVIVKDKKDSSSDVEIIEPDVNEQDVEIDVDNFEDADEHVKEFLGKYQRNFENTEFKCRFCKKNFEKLEQAVEHCDVHKHELDDGIVFPCPLCDYGYENSKWLKAHLNAAHDNMNKDKSTEENTIKEENSQNKEDDADKIINNSEDVKDLHSPVAKRTRSSLKKNEEDIINGTPETLQSKESESPMVDLQNTNINIKVEVKQEDSSDSDSIWIVHTGDDDDEQLKKLLQVTEAKRDVNDLKRHKCFTCRYYYDIKSNFLLKRKKKTREPNDPQIVTCHNCNESFTSKVRLKFHMQFHEATNLLTSDGQYVCADCKDTTFPNETKLFDHVHFQHNKQKRWQCPVKDCGKTFFLRATLTKHSRMHTDTRRYVCVTCGKRFLDKQTLDEHGVTHLQIKPFQCHICLKQLTRRSRLRMHLRAHEEELSPALVLVCAMCSRAFRDHVDAQEHAAKSTECIDEFANDLKEEATSTEQLSPTSGIVRHTVLVTETRGKTSIPKEVNTEESETLLAALDDVARNIIRVVDIEKAFRCEYCEDVFYLEDALNNHRLLHKDVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRSATEASTEGRAGPASAGILGYGGFPVVKHFLCEDCGRSYLHWTYFQVHRRMKHANENYIFKCNQCEMTFPNSWSATYHRKKVHSKNSQDANGGFTKIVRENYRIPCRDCDEVLPNKIALYKHRQKEHCDATLMDKEDEWSELEEADTTVCSKCGLDLHNVVSLGQHDKDVHGCSSEVRTSAHSCPVCARSFRSASMRDEHVRVHTGERPFPCDVCGVAFRRSTAMRNHRLLHTGARPWGCAHCPKRFRVKSDLRTHVRLKHPAHLAVIEVEGRSCTQEEVLQHLDNNNISRDKVIEITMITFPQNTTNIVPNTVRALSMLSDFPRTVIPCDWKTRVISLGQSQETLQPPPRRGRGIDKNPRRAAILQRCDDLPQTSQDTSTYVQNEGENIPTLDVQLLLQNGTLLNKSQVIQVNDGILLEQSTTNTAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00205454;
90% Identity
-
80% Identity
-