Basic Information

Gene Symbol
-
Assembly
GCA_034621355.1
Location
JAXAVZ010000166.1:948018-965213[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.17 12 7.3 1.4 1 23 35 58 35 58 0.95
2 11 0.1 7.1 8.0 0.4 2 23 66 87 65 87 0.95
3 11 1 70 4.9 2.4 1 23 91 114 91 114 0.88
4 11 3 2.1e+02 3.4 2.2 1 21 121 141 121 144 0.82
5 11 0.00018 0.013 16.6 0.1 2 23 151 173 151 173 0.95
6 11 0.0001 0.0069 17.5 0.1 1 23 180 202 180 202 0.95
7 11 0.00018 0.012 16.7 0.3 3 21 211 229 210 234 0.93
8 11 3.5e-06 0.00024 22.1 0.8 1 23 242 265 242 265 0.92
9 11 9.2e-05 0.0064 17.6 1.4 1 23 271 294 271 294 0.96
10 11 1.5e-05 0.001 20.1 0.4 3 23 305 325 304 325 0.98
11 11 0.038 2.6 9.4 1.0 2 23 332 354 331 354 0.92

Sequence Information

Coding Sequence
ATGTGGTATGAAGACAAAGTAAAAACTGTGCAGTTGACTGAGGAGGAAATGTTGCACGATCGAGAACTGGACGCTGCcaataacaaatatttgaaGTCGCCATACAAATGTCAGAAATGTATTATAGGTTTTGATCATAACCTGGCGTTTAACCAGCATATGGAGCTAAGGCATAAGaagGTGGATGGTGCGCTTATATGTAATATATGTGAGTCAGTCCAAAACACAAAGTCGGCGTATAAAGCGCATCGCAACCGTCATTATAGAAgATATGAATGTTTGCACTGTAAGAACAGATTCACCAACGTACGCCCTGCGCTGAACCACTACAAGAACACGCATGGCAACATCGATATCAAATATGCGTGCAAACAATGTGATTTCACTACtgaatCCTACTCAAGGTTACGGTTCCATAGAGACTATCGTCATAAAGGAGAGATAAAACCTGAATGTGACCTGTGTGGCAATGTCTATGCCAACAAGGACTCGCTACGGACGCACATCTTGAACATCCACAAACTGACCAACCACGTCTTCGCCTGCGGGACTTGCGGCAAAGAGTACCGCACTAGAGCGGGCCTCCGGTCACACGTCCTGTTGCACAACAAGAAGGACCCGCCCGCGTACTGCGCCGACTGTGACATCACGTTCCGCAACGCTGCCGGCCTCAGGCAGCATCTGAGGAACACTAACAAACACAACTCCGAGAATATCAAGAGATTTACATGCAATGAGTGCAATGAATCGTTCCGCACCAAACGAGAACTGCAGGACCATATCGACTTCGTACACCTGAACCGTACCAATTACACATGCAGCAAGTGCCCTAAgTCGTATATGAATAAAAAACGTCTCAGAATTCACATATTGTACGTGCATGACAAGATTCGTCGGCCGAGGGACAAGATATGTGACCACTGCGGAAGAGACTTTGACACAAGTATCGCTCTAATAACCCACATAAGATCCCACACTGGTGAGAGACCTTTGAAATGTGCTCACTGCGCAGCGACCTTCGCACACAGCGGCGCGCTCTACACACACAACAAGCTGGTGCACAAGAAGAAAAAACCTGTTGCAGCCTCGTAA
Protein Sequence
MWYEDKVKTVQLTEEEMLHDRELDAANNKYLKSPYKCQKCIIGFDHNLAFNQHMELRHKKVDGALICNICESVQNTKSAYKAHRNRHYRRYECLHCKNRFTNVRPALNHYKNTHGNIDIKYACKQCDFTTESYSRLRFHRDYRHKGEIKPECDLCGNVYANKDSLRTHILNIHKLTNHVFACGTCGKEYRTRAGLRSHVLLHNKKDPPAYCADCDITFRNAAGLRQHLRNTNKHNSENIKRFTCNECNESFRTKRELQDHIDFVHLNRTNYTCSKCPKSYMNKKRLRIHILYVHDKIRRPRDKICDHCGRDFDTSIALITHIRSHTGERPLKCAHCAATFAHSGALYTHNKLVHKKKKPVAAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-