Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.0029 9.6 6.5 0.0 15 47 34 66 23 73 0.88

2 3 0.0017 5.5 7.3 0.0 15 48 134 167 121 239 0.84

3 3 0.0025 8.3 6.7 0.0 14 46 243 275 230 282 0.86

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.0029	9.6	6.5	15	47	34	66	23	73	0.88
2	3	0.0017	5.5	7.3	15	48	134	167	121	239	0.84
3	3	0.0025	8.3	6.7	14	46	243	275	230	282	0.86

Coding Sequence: ATGGCTATTTTTGTTGGCATAGTTTACAataatatctacttatttatGGTTATCCTACTCTTGATAATTGCGGAAGCGTACACTGTTCGCAACGCGACGGACGGCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGCGCCTGTCACTTGTGTGACGTCAAAGTGCCAGGTAACTGTTGCGTGCTTCAAATGTGCGGAAGCGTACACTGTTCGCAACGCGACGGACGGCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGCGTACACTGTTCGCAACGCGACGGACGGCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGCGCCTGTCACTTGTGTGACGTCAAAGTGCCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGCGCCTGTCACTTGTGTGACGTCAAAGTGCCAGGTAACTGTTGCGTGCTTCAAATGTGCGGAAGCGTACACTGTTCGCAACGCGACGGACGGCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGCGCCTGTCACTTGTGTGACGTCAAAGTGCCAGGTAACTGTTGCGTGCTTCAAATGTGCGGAAGCGTACACTGTTCGCAACGCGACGGACGGCAGCGCGGAGTTCGCGTGCAAGCACTGCCCGGGCGTGTTCCGCTCAAACAACTGCTTCTCGCAGCACTACAAGCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGCGCCTGTCACTTGTGTGA
Protein Sequence: MAIFVGIVYNNIYLFMVILLLIIAEAYTVRNATDGSAEFACKHCPGVFRSNNCFSQHYKQVHLKERPKLRACHLCDVKVPGNCCVLQMCGSVHCSQRDGRQRGVRVQALPGRVPLKQLLLAALQAAYTVRNATDGSAEFACKHCPGVFRSNNCFSQHYKQVHLKERPKLRACHLCDVKVPARSSRASTARACSAQTTASRSTTSRCTSRSGPSCAPVTCVTSKCQVTVACFKCAEAYTVRNATDGSAEFACKHCPGVFRSNNCFSQHYKQVHLKERPKLRACHLCDVKVPGNCCVLQMCGSVHCSQRDGRQRGVRVQALPGRVPLKQLLLAALQAGAPQGAAQAARLSLV

Sequence clustering based on sequence similarity using MMseqs2