Basic Information

Gene Symbol
ZEB2
Assembly
GCA_949126915.1
Location
OX421416.1:20413611-20426552[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 1.2 1.1e+02 4.4 2.0 3 21 448 466 446 470 0.92
2 12 0.52 47 5.6 1.6 2 19 492 509 491 515 0.89
3 12 0.0013 0.11 13.8 2.0 1 23 529 552 529 552 0.97
4 12 0.037 3.4 9.2 2.2 1 23 557 581 557 581 0.89
5 12 0.08 7.2 8.1 0.2 2 21 632 651 631 652 0.90
6 12 2.1e-05 0.0019 19.4 1.2 1 23 709 730 709 730 0.98
7 12 0.001 0.091 14.1 3.8 1 23 736 759 736 759 0.97
8 12 0.00048 0.043 15.1 2.5 2 20 785 803 784 805 0.94
9 12 0.12 11 7.6 2.0 3 23 810 832 809 832 0.95
10 12 0.11 9.9 7.7 6.2 1 21 839 859 839 861 0.95
11 12 0.029 2.6 9.5 1.6 1 21 867 887 867 892 0.92
12 12 0.022 1.9 9.9 0.4 1 23 898 921 898 921 0.96

Sequence Information

Coding Sequence
ATGCTGTCTCCGCGCGATGACGACGACGACGACAGCCACCTCTGCATCAAGTGCAACACCACCATCGTCGGCCTCGACAACTATGTGAAACATCGAAAGGAAAGATGTGGGAAATTAAACAAACCGAGCACATCTAAAGACATTCCTTTGGATACTCTCGACCCATATAGTCTTGGTGCAGATATCTTCTTCCAGTCTCTCGAGTTACAAAGCAGTGTCAAAAAATCTTCTTTATCCCGAATGACACCGCCAAATACTATGTCCAAAGCAGTTTTAGATCCTAAATCTACTCTTACATCTAGAGATCTTCCACGAATGAGTCCTATAGAATCCAATTTAAGAGATGAAGACTGGATTGGAGGACATCCTTTAAGACATAGCGGTCACGAGGACAACCAAACGAAGCTTATAAATGCAGTTGCGAGTATTAGTGGTACAGCTAAGAAAGATATTCCAACTTCAACCTACAGTATTGCAGGTTATAATGACTTCAAATGTGTTGAGGATTACGATGAGCTAGATGACTCTGACGAAGATGATGACGAAGAAGCAGAACCTGGACCTCCGTCCCCGAACTACATGGGAGGAAAATGGCGACCTGCATCTGCAGATCACGACGACTGGGATATGAGAGATGATCAAGAACATACAGGAGGAAAGTGGAGACCAATAATGGCTGAACATAACGACAGAGATGAAGATTATGACGCTCCTCCACCGGGGCACACTAAAGGGAAATGGGTACCTGGCCacgaaaaaacacaaattatgcAGACAACCATACAGACAAAGGGATCAGTTCAATACTGGTGCGGCCCATGCAATCGTCGCTTAGGATCTCGAGCCATTTATGATAAACATCTAATGTCCAAGTTGCACATGAGAAAAGTTCTACCAGAACATGAATTAGAATTCTCTGGACATTTAGAACCTATAAAAACGGCAAAACGACCTTTTCGTTCATCCCAATCAAATAGTATTTATGCACAAACTAGAAAGAAAGTTAAAAAGCAACTGAAGCCAAAGATAGAAATTAATGAGGACAAGAAAAAAAGGAAACGAAagcctatcttcgtccactgctcCGGATGTAAGTCGAAGGTAAAACAGTATTTGATGGGAAAACATTTAATTTCCCATTACCACTTTCGAAAAGTGAATGACATCAAAAGTGACGCTTATAGGCAATTGATACTAGACAACATAGAAGCCATTGTTCACCAGTCTCCATTTCAATGCAGTCCTTGCAAGTTTTATACGAACTGGTTGTCCAATTTCATGCAGCATTGGTTTTCAGAGGaacatgaattaaaaatatctgctTTAGAAGGAAGATATTGGTGTTCATTCTGTAAATTCGAGTGTGATACTTCTCAAGAAATGCAAAAACACATGTCTGGCTCAGATCACAGTGAAGTTGTAGCTGTTATAAACAGATCCATGCCAATAATAATACGGAAGAAAAGTATACTTAAATGTGTTACCTGTGGAGAAGAGTTTCGATACAACATCGAGGCCAAACGACATTGTAAAAGAACTGGTCACGCTATGCCTTATACAGCATCAGACGATTATCAGGAACTACATAAATGTCAGCTTTgcaatataaagtttaaatcttCTTTGACGCTGGCagctcatttaaaaataaaacataagcaAAAAGCCTTCTTCTGCTTAGTGTGTTctaaaactttcaaaacttcGATTGAAGCTAAAGTGCACCGCCACACTTCAGAACACAGAACAAGAAGAAAAGAGATATTATTCGATAAAGGAATTTCTGTCAAGAATTTAAGTAGAAAGTGCCCATATTGTACCGATGaggttatattaaaaagtatcctCGAACTAAAAGAGCACATACGCATCACTCATCCTGAAATTAAAAAGAGGTGCCCAAAATGCGGAATGACATTCGTTTTATTCCAAGAAGTAAGCAGTCACATCAAACGGAAGCAATGCCAGTACCCGAACCAACCAACCTCTTCCATAGTCTGGAGTTGCAGCCAGTGCCTCTTCAGCACCGACTCGCAAGCAGAGTGCTACTTCCACGAAGTCTTGCACGCGACTCCTGCCAAAGAAACTTGTCAAGCTGGTGGAAAACTGAAGTTTGTCGACAAATACTCTTGTCCACTTTGCCCGAAAAGTTTTAAGAAGAGATCACTTCGTCAACATCTGAGAATACacacttttgaaagacctttcgtGTGCTCCTCTTGTGGTTCAAACTTTACAACACAGTCATCGCTTTCCACTCATCACAAAAAAACTCATGGCGAGAGAATTATGACGACTAATCCACCTAAAAGAGTTATAGTCCCAGTGGAAAGTTGTTTGAGAGAGGACAGCAAATGCAAGACATGTTTCAAAGTGTTCAATAATCGGAGCGCGCTGAGACGACATGCCTGCGAATCAGCGAAACTCTGCCCCCACCAGGGCTGTGACTTTGTTGCCTCTTCTACAGCACACCTTTCCAAACATAGAATGACACATGGGGAAGTAACAAAAAACTACGAATGTTCATTGTGTCCCTTCAAAACAAACCAATCCAGCCACATGAAGAGGCACACACGCTGTCACATGGGTGTGAAACCTTATGCCTGTCCTCACTGCGTTTTTACTTGTGGAAGTTTGGAAAATCTGCGTAAACATGTGTTGCGTAGCGGGCGACACCCAGGGATGAACCTGTACTACTGCCAGTCGTGTGTGTACTCCACCAACACTGCTACCGAACTCCGTGCTCACTTGACTTCGGTCCACGCTGAACATTATGACTCGAAATCTGCCATACAAgctgttaaagttattttactAAAGAAAACCTCACCAGATGTCGTTTGTGATGAAAATTTGGCTAGTagctcttaa
Protein Sequence
MLSPRDDDDDDSHLCIKCNTTIVGLDNYVKHRKERCGKLNKPSTSKDIPLDTLDPYSLGADIFFQSLELQSSVKKSSLSRMTPPNTMSKAVLDPKSTLTSRDLPRMSPIESNLRDEDWIGGHPLRHSGHEDNQTKLINAVASISGTAKKDIPTSTYSIAGYNDFKCVEDYDELDDSDEDDDEEAEPGPPSPNYMGGKWRPASADHDDWDMRDDQEHTGGKWRPIMAEHNDRDEDYDAPPPGHTKGKWVPGHEKTQIMQTTIQTKGSVQYWCGPCNRRLGSRAIYDKHLMSKLHMRKVLPEHELEFSGHLEPIKTAKRPFRSSQSNSIYAQTRKKVKKQLKPKIEINEDKKKRKRKPIFVHCSGCKSKVKQYLMGKHLISHYHFRKVNDIKSDAYRQLILDNIEAIVHQSPFQCSPCKFYTNWLSNFMQHWFSEEHELKISALEGRYWCSFCKFECDTSQEMQKHMSGSDHSEVVAVINRSMPIIIRKKSILKCVTCGEEFRYNIEAKRHCKRTGHAMPYTASDDYQELHKCQLCNIKFKSSLTLAAHLKIKHKQKAFFCLVCSKTFKTSIEAKVHRHTSEHRTRRKEILFDKGISVKNLSRKCPYCTDEVILKSILELKEHIRITHPEIKKRCPKCGMTFVLFQEVSSHIKRKQCQYPNQPTSSIVWSCSQCLFSTDSQAECYFHEVLHATPAKETCQAGGKLKFVDKYSCPLCPKSFKKRSLRQHLRIHTFERPFVCSSCGSNFTTQSSLSTHHKKTHGERIMTTNPPKRVIVPVESCLREDSKCKTCFKVFNNRSALRRHACESAKLCPHQGCDFVASSTAHLSKHRMTHGEVTKNYECSLCPFKTNQSSHMKRHTRCHMGVKPYACPHCVFTCGSLENLRKHVLRSGRHPGMNLYYCQSCVYSTNTATELRAHLTSVHAEHYDSKSAIQAVKVILLKKTSPDVVCDENLASSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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