Basic Information

Gene Symbol
-
Assembly
GCA_949126915.1
Location
OX421442.1:2885405-2890280[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.014 1.3 10.5 0.4 3 21 230 248 228 249 0.94
2 9 0.013 1.1 10.6 1.0 2 23 276 298 275 298 0.92
3 9 0.12 11 7.6 0.3 2 23 318 339 317 339 0.97
4 9 0.0016 0.14 13.5 0.0 2 23 344 366 344 366 0.93
5 9 0.0019 0.17 13.2 5.1 2 23 370 392 369 392 0.97
6 9 0.0015 0.13 13.6 0.9 3 23 401 422 400 422 0.92
7 9 3.6e-05 0.0032 18.7 0.3 3 23 431 452 429 452 0.96
8 9 0.00054 0.049 14.9 3.9 1 23 458 480 458 480 0.98
9 9 0.00081 0.073 14.4 2.9 1 23 486 509 486 509 0.97

Sequence Information

Coding Sequence
ATGGACTCGAAAAAAGTATGTCGGTGTTGTCTCTCGCGGGACTGTTCTAAAGAATTAACTCGGGAATACTTCCATGGTTCAGTTACAGAAGTATACTCTGAAATGTTAGCGAGTACCTTCAATTTAGACGTCAACAAACACAGAATGTTATCCAACCTCATTTGTGATGGTTGTGTCAGGAGTATCAGAGAAGCATCCAAGTTCAAGGAAACAGTCAAAGCCTCCGAGAAGACATTGTTGGAGTTGTGGAATGCCCCGCAGTTTGACACAGAGAAAGAAGTGCCACTAAAAGAAGAAAACGAAGATTACAGCGACGATTTAGACGATCATTTGGACGATGACTTCGCTTGGGATGTTGCTGATGCACCAGCTGACCATGATAAAGGGCAAATATTCGTCATAAAATTGGAGTCTAAAAAGGAGAAGAAAATTCACCGTAGCCTCAAGGAAGTCTCTAGAAAGTTAAGAAGCGAAGTTAGGGAACCCACTGCTGACAGGATGAAGGCCAAACCACGAAGCAAGTCGATTAGGAATACAAAGAATTCCACGGAAACCAAAAGTTCTTCAAAGTTCGTGTGTAAAAGACCCCCGCCAACAGAGTCCCAAATAGCGTCCCGGGAGAACTCCCTAAAACTAGTACAGAACTCCAATATGTGCCTATTTAAGtcactaaaaacaaaatacggATGCTTTCATTGCAAAGAAAGCTTCATTACTATTCAAGAACTTCGGCAACATACAAAcgcttgtaataataaaaacctaAAACTCAGGTTCAATCTTCTCACAGGCCTTTCATACAAAAACGTCGACATATCAGATCTCACTTGCAGTAATTGCCCAAAAAAATGCGACGATTTGAATGGATTACAGTCTCATTTGACTGAGGAACATAATATAGTATTCAATGGAGATCATTTTCTAATACCATACAGATTAAATAGCGGAAATAAATGTGTACTATGCGCGCAAGATTTCAATACATACCTTCGTTTAGCTATACACATGAACACACATTTTCCGCATAACGTCTGCGAAATCTGCGGGGTCTCTTATATCAATCGTATGAGTTTAAGAATGCATGTGAATGCTTTGCATAAGGAAAAGAAGTGCACCCATTGTTCGGCAACGTTTTCTAGTCCACATTTGAGAGTGAAACACATGCGGAAAATCCACAACTATGGGGGTTACAAAAGATATTGTTTGCTCTGTAATAAAACATTCAGATATACATATTTGCTTCAAGAACATAGAATACAGGAACACGGAGTTAAAAGGGAAACGTCAAATTGTCCGGAATGTAGTAAAACATTTCTATCGCCACAAAATTTGAAAGTGCACATAAGATCAGTGCATATAAAGGAACGGAATTATCCTTGTACAGTTTGCGGGATGAGGTTCTTTACGAAATGTGATCAGAAACGCCATGAAAGGACGCACGAGGATGTTCGTTCCTTTTCATGCAGCTTTTGCGAGGGAAAATTCAAGACTAAAGATTCCTGGCGACGACATTTAAAGCGACAGCATGGACATCTTAATCagacagaataa
Protein Sequence
MDSKKVCRCCLSRDCSKELTREYFHGSVTEVYSEMLASTFNLDVNKHRMLSNLICDGCVRSIREASKFKETVKASEKTLLELWNAPQFDTEKEVPLKEENEDYSDDLDDHLDDDFAWDVADAPADHDKGQIFVIKLESKKEKKIHRSLKEVSRKLRSEVREPTADRMKAKPRSKSIRNTKNSTETKSSSKFVCKRPPPTESQIASRENSLKLVQNSNMCLFKSLKTKYGCFHCKESFITIQELRQHTNACNNKNLKLRFNLLTGLSYKNVDISDLTCSNCPKKCDDLNGLQSHLTEEHNIVFNGDHFLIPYRLNSGNKCVLCAQDFNTYLRLAIHMNTHFPHNVCEICGVSYINRMSLRMHVNALHKEKKCTHCSATFSSPHLRVKHMRKIHNYGGYKRYCLLCNKTFRYTYLLQEHRIQEHGVKRETSNCPECSKTFLSPQNLKVHIRSVHIKERNYPCTVCGMRFFTKCDQKRHERTHEDVRSFSCSFCEGKFKTKDSWRRHLKRQHGHLNQTE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-