Basic Information

Gene Symbol
-
Assembly
GCA_949126915.1
Location
OX421422.1:6690848-6707028[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.001 0.092 14.1 2.1 1 23 427 449 427 449 0.97
2 20 0.0033 0.3 12.5 0.6 1 20 455 474 455 477 0.94
3 20 1.1e-05 0.00097 20.3 3.3 1 23 499 521 499 521 0.98
4 20 2.1e-05 0.0019 19.4 3.9 1 23 527 549 527 549 0.99
5 20 3.9e-05 0.0035 18.5 5.3 1 23 555 577 555 577 0.97
6 20 2.5e-05 0.0022 19.2 7.1 1 23 583 605 583 605 0.97
7 20 1.1e-06 0.0001 23.4 2.8 1 23 611 633 611 633 0.97
8 20 0.00011 0.01 17.1 6.7 1 23 639 661 639 661 0.97
9 20 0.00011 0.01 17.1 6.5 1 23 667 689 667 689 0.97
10 20 5.4e-07 4.8e-05 24.4 1.9 1 23 695 717 695 717 0.98
11 20 5.5e-05 0.0049 18.1 7.9 1 23 723 745 723 745 0.98
12 20 8.7e-06 0.00079 20.6 6.6 1 23 751 773 751 773 0.98
13 20 6.1e-05 0.0055 17.9 2.4 1 23 779 801 779 801 0.98
14 20 5.9e-05 0.0053 18.0 4.7 1 23 807 829 807 829 0.97
15 20 0.00015 0.014 16.7 5.8 1 23 835 857 835 857 0.97
16 20 8.5e-05 0.0076 17.5 5.2 1 23 863 885 863 885 0.98
17 20 9.8e-05 0.0088 17.3 7.5 1 23 891 913 891 913 0.97
18 20 4.8e-06 0.00043 21.4 4.1 1 23 919 941 919 941 0.96
19 20 0.0008 0.072 14.4 0.3 1 23 948 970 948 970 0.96
20 20 0.022 1.9 9.9 3.3 1 23 982 1004 982 1004 0.99

Sequence Information

Coding Sequence
ATGAATCCTGATCACCACAGTATCAATACGGGTGGTGGCCAGCCTCCTGGAAGTGCAGAGTCGCAGACTCAAAGAATACAAAGtgcgcaacaacaacaacagcagcagcagcagacCACCAATTTACCTGCCACTACTTCTGCGACAGATCTTCGAGTAAATTCAGCTGCTGTAAACGTCGCTTTGTCTAGCGTAGCCAAATATTGGGTGTTTACAAATTTGTTTCCTGGACCTATACCTCAAGTATCAGTTTATGGACTACCAACAGGAGCTAGAATCGACAATGGGAAACCTGTCCAGGATCTTGGTCAGACCCATGCAAGTATACTTAATGGAGATCCGAATATTATATTGGGGCATCACACTGGACAGCCCCAGGTTACAGTATCTGGACCTGGAGGTCAACAAATACCCGTCTCACAAATCATTGCCACACAGTCTGGTCAGACTCATGAAGCACTGGTGGCTCATAACCAACAACAGGAGTTGGCTGCCCAGCAAGCATCAAGCACTGCTCAGGTCACAGTTAGCCCAGGCCAGCCTCACCAGCAGGTACCCAATAATCGGGTCGAGTTTGTACAACACCATAACATTGATATGGTAAATGacatgGGACATCATTCACAACAACACTTAATGCAGCAGCAACTAATGGGTGGCACTCGCCAAGAACATGCAAATCAGcagATCCAATTGACGGTGAGTGAAGATGGCATAGTGACTGTGGTAGAGCCAGGTGGAGGCAAACTTGTTGACAAGGAAGACCTGCATGAAGCTATCAAAATGCCTGGAGACCACACACTAACTGTTCATCAGCTACAGCAAATTGTTGGCCAGCAGgtAATTGACAGTGTAGTTCGGATAGAACAAGCTACCGGTGAAGCTGCCAATATTCTAGTGACGCACAACCCAGATGGTACCACTTCCATAGAGGCCAGCTCTGGCGATCAGCTGATAGTTAAAGATGAAAAGGCTATGGGAAAAATTGAAACTGCACAATATGCTGAAATCAAAGATATTAAAGGCATTGACCTCAAGGGCGTAGGAGCAATGGGAATGGAAGGTGCAGTGGTTAAAATTTCCGGTGCATCAGAACATGACCTACATGCCATGTATAAAGTAAATGTAGAAGACTTATCACAATTGCTGGCTTACCATGAAGTGTTTGGGAAATTAAATGCTGAAGGGCAGCAACAGACAAAGCAAATAGAGGTAGAAGTGGAAGCAGAAGCAGGCCCTAGTACTGCTATGTCAGAGGCGGAATCATCGCCGGGCCATCACTCCTGCGACATTTGTGCTAAAGTATTCCAATTCCGTTATCAGTTAATTGTTCATAGGCGATATCACGGTGAAAGCAAACCATATACGTGCCAAGTTTGTGGTTCTGCTTTCGCTAATCCCGTAGAGTTGTCAAGGCATGGAAAATGTCATCTGGctgTAGAACAACTGGCTACTGGCGAACGGCATACTAAAAGACAAACACAAGACAAGCCATACGCATGTTCCACATGCCAGAAGACATTCTCCCGCAAGGAACATCTAGACAACCATGTCCGCAGTCACACTGGCGAGACGCCATATAGATGTGAGTACTGCGCGAAGACATTCACTCGTAAAGAACACATGGTAAACCACGTAAGGAAACATACGGGCGAGACACCGCATCGCTGCGAGATCTGCAAAAAGAGCTTTACTAGGAAAGAGCACTTTATGAACCACGTTATGTGGCATACAGGTGAAACTCCGCACCATTGTGAATTATGCGGGAAGAAGTATACTAGGAAGGAGCATTTAGTGAACCACATGAGATCGCATACAAAAGATACGCCATTCCGATGCGAACTATGCGGAAAGTCTTTTACGAGAAAGGAACATTTCACCAGTCACATACTGTGGCATACGGGCGAAACCCCACACCGTTGTGACTTCTGTTCGAAGACTTTCACCCGCAAAGAACATTTGTTAAATCACGTCCGTCAACACACGGGCGAGTCTCCGCATCGCTGTAACTTCTGTTCGAAGTCTTTCACGAGACGGGAACATCTCGTCAACCACGTGAGACAACATACAGGAGAAACCCCCTTCCAATGTGGATATTGTCCGAAGGCCTTTACAAGGAAAGACCATTTAGTAAACCACGTACGACAACATACGGGCGAATCACCGCACAAATGCTCATTTTGCACGAAATCGTTCACCCGTAAAGAACATTTAACGAACCACGTCCGACAGCATACGGGAGAATCGCCCCATCGCTGCACGTATTGCGCCAAGTCCTTCACGAGGAAAGAACATCTTACCAACCATATCAGACAGCACACGGGCGAAACGCCACACAAGTGCACGTATTGTCCACGAGCCTTCTCGCGGAAGGAGATCCTGAACAACCACATCAGGCAGCATACCGGCGATATGCCGCATGTCTGCACGTACTGCCCGAGAACTTTCTACAGAAAAGAGCATCTCGTCATACATACAAGGCAACACACGGGCGAGACGCCGTACAAGTGCACATACTGTGCGAAGTCTTACTCTCGCAAGGAGCACCTCACGAACCACGTGCACCTGCATACTGGCGAGACGCCGCACAAATGCGTCTTCTGCGCTAAGACCTTCTCGAGAAAAGAGCATCTCACCAATCACGTCAGAATACATACCGGAGAGTCACCACATCGCTGCGGTTTCTGTCAGAAGACCTTTACAAGGAAAGAACACTTAACGAATCATCTGAAGCAACACACGGGAGACACGCCCCATGCGTGCAAAGTTTGTTCCAAACCGTTCACTAGGAAGGAGCATCTAGTCACGCATATGAGATCTCACAGTTGCGGGCAACGGCCGTTTAGTTGCGGAGAGTGCGGGAAATCATTCCCTTTGAAAGGAAACCTCTTGTTCCACGAGCGATCACATAACAAGGGCACCGGTGCAACCAGTAATCGTCCTTACCGTTGTGACGTTTGCTCGAAAGCCTTCTTGTGCAAAGgtcACCTAGTAGCTCATCAGCGGACGCATACAGAAGGTGGTGAAACTGTTGCGGGTGATCCGGTAGAAGCAGAGACGGAAGACTGTGGAGACTGCGAAAAGTGCGAGAAACCAGACGTGGCCCACGAACGGGAAAGGAAACACGATATCAGGGCGACTGTGGAAAATAGAACAGCTGACACCAATGTCGTACAAAATCAACAAAGCAACCCAACTGTGATGCAAATAACAAGCCAACAAGTCCGTACTGCGACGGTGAGTGTACCAAGCGATGCGAGCGTGCAGACGGTCGCTAGCTTCACGGTGAGCGGGCAGCATCACACGGGTACTGCGCTCGCGCACCATCCTGTCACCGTCAACTACTAG
Protein Sequence
MNPDHHSINTGGGQPPGSAESQTQRIQSAQQQQQQQQQTTNLPATTSATDLRVNSAAVNVALSSVAKYWVFTNLFPGPIPQVSVYGLPTGARIDNGKPVQDLGQTHASILNGDPNIILGHHTGQPQVTVSGPGGQQIPVSQIIATQSGQTHEALVAHNQQQELAAQQASSTAQVTVSPGQPHQQVPNNRVEFVQHHNIDMVNDMGHHSQQHLMQQQLMGGTRQEHANQQIQLTVSEDGIVTVVEPGGGKLVDKEDLHEAIKMPGDHTLTVHQLQQIVGQQVIDSVVRIEQATGEAANILVTHNPDGTTSIEASSGDQLIVKDEKAMGKIETAQYAEIKDIKGIDLKGVGAMGMEGAVVKISGASEHDLHAMYKVNVEDLSQLLAYHEVFGKLNAEGQQQTKQIEVEVEAEAGPSTAMSEAESSPGHHSCDICAKVFQFRYQLIVHRRYHGESKPYTCQVCGSAFANPVELSRHGKCHLAVEQLATGERHTKRQTQDKPYACSTCQKTFSRKEHLDNHVRSHTGETPYRCEYCAKTFTRKEHMVNHVRKHTGETPHRCEICKKSFTRKEHFMNHVMWHTGETPHHCELCGKKYTRKEHLVNHMRSHTKDTPFRCELCGKSFTRKEHFTSHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCNFCSKSFTRREHLVNHVRQHTGETPFQCGYCPKAFTRKDHLVNHVRQHTGESPHKCSFCTKSFTRKEHLTNHVRQHTGESPHRCTYCAKSFTRKEHLTNHIRQHTGETPHKCTYCPRAFSRKEILNNHIRQHTGDMPHVCTYCPRTFYRKEHLVIHTRQHTGETPYKCTYCAKSYSRKEHLTNHVHLHTGETPHKCVFCAKTFSRKEHLTNHVRIHTGESPHRCGFCQKTFTRKEHLTNHLKQHTGDTPHACKVCSKPFTRKEHLVTHMRSHSCGQRPFSCGECGKSFPLKGNLLFHERSHNKGTGATSNRPYRCDVCSKAFLCKGHLVAHQRTHTEGGETVAGDPVEAETEDCGDCEKCEKPDVAHERERKHDIRATVENRTADTNVVQNQQSNPTVMQITSQQVRTATVSVPSDASVQTVASFTVSGQHHTGTALAHHPVTVNY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01030446;
90% Identity
-
80% Identity
-