Basic Information

Insect: Musca domestica
Gene Symbol: Runx1
Assembly: GCA_000371365.1
Location: Scaffold18583:106038-148898[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5.4e-73 1.9e-69 230.9 0.0 3 129 91 217 89 217 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5.4e-73	1.9e-69	230.9	0.0	3	129	91	217	89	217	0.98

Sequence Information

Coding Sequence: ATGCATCTCACGACGacaacaaatggtggaggtggggccaacaatgccaacaacacGGCCGCCTCCAATACtgcgaacagcaacaacaacaacaattcgaatacacagaataacaacaacgcgagttcgaataacacaaataccaacaacagttcgaatGGTAACAATAACAATTCCACAGAACAAAATACTCCGCCCACAGCAGCTCAACTGCTCAATGAGGCCTACACAAAAATGACTTCGGATATTTTGGCCGAACGTACATTGGGCGATTTTCTTACCGAACATCCGGGTGAATTGATACGAACCAGTAGCCCGTTGTTTGTGTGTACCGTGCTGCCGCCGCACTGGCGTTCGAACAAGACATTACCGGTGGCATTTAAAGTTGTTTCGCTGGGCGATATTATGGACGGGACAATGGTGACGGTGCGAGCGGGCAACGATGAGAACTACTGTGCAGAGCTGCGGAACTCAACGGCGGTAATGAAGAATCAGGTGGCCAAATTTAACGATTTACGTTTTGTGGGGCGAAGCGGTCGAGGGAAAAGTTTCACCTTAACCATAACCGTTTCAACAAATCCGCCACACATTGCCACATACAACAAGGCCATTAAAGTGACTGTCGATGGACCCCGAGAACCACGCTCCAAAACCAGACAACAGCAACAGTTCCATTTTGCCTTTGGCCAAAGACCGTTTCATTTCTCAACGGATCCACTGTCTGGTTTTCGTATGCCACCAATAGGCAATTGTCAAAGTGCCAGTAATACACACTGGGGTTATGGTTCGGCAACAGCATATTCACCCTACTTGGCCAGCAGCGGCTTGTCATCGTGTACAACACCAACATCGGCGCAGTTCAATAATCCAGCATTGGGTTTCTCGTGTTCATCGAATGAACAGGCCAATAATCAAGATTTCAGTGGTGCTTCTAACCGGGATTGTGTGCCAATGCTGCCCGATTCAACAGCTTCCGACTTGGATCAACATCTCAGCAGCCTTGTGGGTTCTACAACTGGGCAGATGACACATCACAGTTTGCTGGGATCGACGGGACAAACAGCCATCTCATCGACGGTCAATGGGGCCGCCGGAGCTGTTGCCAACTCAATTTTGGTACCACGTTATCACAACTCGAACAACGATTACAATGTGCACTCCAGTCAAAATGGTCCACGCAGTCTCAGTGATTCGTCACAGGCCGAATCGCCGGTACAGGAAGATCTACTCTCTACAAATACACCAAATTTGGGTGGGGCAAATGGCAATGCGGCCACAAATGGCGGTACGAACAGCAACTCCAATGGCTCGGCCAATAACTCCCTGGTCGGTTCTAATCCCAATTTTACTAATCTCGTAAATCAAAGTCAAAATCCCGCTGGCTATGGTGGCACGGCTGGGGCGGGAGTGGGTGTTGGTGGCGGCCATGGTGGTGCTGCAGGAGCCGGCTGTAATGGTTCCCTTTATCCCGTTCTTCCGGCCAGCCTATTGTATTCTCAGCTATATACCGCTGCAAATCAGTCACATGGTTTCCACTCACATTCCTTGCCCTCACACACATCGCCCAATTCAACGGTCCACGGTGAGCTGCAAAGTGTAATGGATCACATTAGCAATGTGGGAGTGAGACAGCAACACAACATTATGTCCGGCGGTGGGGTGACACATCCCGGCGATTTGACTTTGATTGGCAATTGCGGCGCCTCGGTGCGTAACATCGAAGATGGCAATACTAATCGCCAGTTGACAGCATTGGCTGCCCATCGTGGTCATCATAATCCTGGCGATAACGGTAGTGTTTGGCGGCCATATTGA
Protein Sequence: MHLTTTTNGGGGANNANNTAASNTANSNNNNNSNTQNNNNASSNNTNTNNSSNGNNNNSTEQNTPPTAAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNSTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSATAYSPYLASSGLSSCTTPTSAQFNNPALGFSCSSNEQANNQDFSGASNRDCVPMLPDSTASDLDQHLSSLVGSTTGQMTHHSLLGSTGQTAISSTVNGAAGAVANSILVPRYHNSNNDYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGGANGNAATNGGTNSNSNGSANNSLVGSNPNFTNLVNQSQNPAGYGGTAGAGVGVGGGHGGAAGAGCNGSLYPVLPASLLYSQLYTAANQSHGFHSHSLPSHTSPNSTVHGELQSVMDHISNVGVRQQHNIMSGGGVTHPGDLTLIGNCGASVRNIEDGNTNRQLTALAAHRGHHNPGDNGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01314442;
90% Identity: iTF_00679253;
80% Identity: -