Basic Information

Gene Symbol
-
Assembly
GCA_037114965.1
Location
CM073431.1:67965817-67968484[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 5.2e-05 0.0038 19.1 2.3 1 23 135 157 135 157 0.98
2 11 3.8e-05 0.0027 19.5 1.2 1 23 163 185 163 185 0.98
3 11 3.9e-05 0.0028 19.5 2.0 1 23 191 213 191 213 0.98
4 11 4.9e-06 0.00036 22.3 1.5 1 23 219 241 219 241 0.99
5 11 3e-05 0.0021 19.8 0.7 1 23 247 269 247 269 0.98
6 11 1.5e-07 1.1e-05 27.0 0.4 1 23 275 298 275 298 0.97
7 11 5.4e-05 0.0039 19.0 2.3 1 23 304 326 304 326 0.97
8 11 1.6e-05 0.0012 20.6 0.1 1 23 335 357 335 357 0.96
9 11 1.7e-05 0.0012 20.6 3.9 1 23 363 385 363 385 0.99
10 11 2.6e-06 0.00019 23.2 1.7 1 23 391 413 391 413 0.97
11 11 9.2e-07 6.7e-05 24.6 1.9 1 23 419 441 419 441 0.98

Sequence Information

Coding Sequence
ATGGAAAACAATTATACGAATCTAAATAGTcataatatttgtagaatttgcTTAACTAAGGATCTTACAATGAAGTCTCTGTTTGAGGAGAATTTCCTAACAATTTTTCAAGAAGTTACTACTTTGGAGtACTGCGAAAACGATAGTATGCCTAAAGCAATATGTTGTTATTGTGTGGATAACTTGAAGCATTTCATGTCATTCAGATTACAAGCTATAGAGAACGATAATTTGCTACGCAGAATAATAGCAGTACAAAACACCAATTGCTATAAAGACGAAAGTAACATTTATTTGGATGATATTTGCGTCGGTAATGAGAACGatgattataaaaataaatgtgggGATATAAACAAACAACCAAACATAGTTCAAACTGAAAATTGTgccaaaaacaaatttgtgtGTAGTGTATGTAACAAACAAGTTAAAACAATTCACTCATTGCGAAGACACATGAAAATTCACTCTGGTATTAAACCTTATAGTTGTACTTTATGTGGAAAGAAATTTTTAGAACAAGGTAATCTGACAAAACACCTCAGAAACCATAGCAAAGATAAGAAGCACCAGTGTAACGAATGCGGTCTACGATTCTATGAGAGAAATAAATTGATGATACATATTAGAACTCATACAGGCGAGAAACCATTTACTTGCAAAATATGCAACAGAGCCTTTGCTACACATGCTCAGGTTCAGATACACATGAAGacACACACTGGAGAAAGACCATACACTTGCGAAATTTGCCAAAAGACATTTCCATACAGTGGTTCCTTAGACACTCATAAAAAAATTCACACTAACGAGCGAGCTTACATTTGTAACGACTGTGGAAGGTCTTTTACTCAGAAAGTTAACTTAATAGGCCACATTAGGAGTAAGCACACCAACGAATGTCCCTTCATGTGCAGTGAATGCGGGCAATCTTACCCAACTCGGGAGCAATTAAAAAATCATTCTAGACACCACACTGGCCAAAAGAAACCACTCAATCATGCCTGCAAAATATGTGGGAAAGCGTTTGCCTCAGCAGGTGAAGTGAAAATCCATACTCGAATTCATACGGATGAAAGACCTTATCAGTGTGACTTTTGTGGGAAAAAGTTTAGAGCATCTTCACATATGACATCCCACAGGAGAATACATACAGGGGAGAAAAACCATAACTGCAGTTTCTGTGGGAAAGCATTTAGGGAGTCTTCGACATTAAAAATTCACATTAGAATACATACTGGGGAACGCCCCTACAATTGTACAGTGTGTGGCATGAAATTCACACAAAGCAATACTCTCAACACACATATGAAGACACATGGAAATATTCAAgaaattaagtaa
Protein Sequence
MENNYTNLNSHNICRICLTKDLTMKSLFEENFLTIFQEVTTLEYCENDSMPKAICCYCVDNLKHFMSFRLQAIENDNLLRRIIAVQNTNCYKDESNIYLDDICVGNENDDYKNKCGDINKQPNIVQTENCAKNKFVCSVCNKQVKTIHSLRRHMKIHSGIKPYSCTLCGKKFLEQGNLTKHLRNHSKDKKHQCNECGLRFYERNKLMIHIRTHTGEKPFTCKICNRAFATHAQVQIHMKTHTGERPYTCEICQKTFPYSGSLDTHKKIHTNERAYICNDCGRSFTQKVNLIGHIRSKHTNECPFMCSECGQSYPTREQLKNHSRHHTGQKKPLNHACKICGKAFASAGEVKIHTRIHTDERPYQCDFCGKKFRASSHMTSHRRIHTGEKNHNCSFCGKAFRESSTLKIHIRIHTGERPYNCTVCGMKFTQSNTLNTHMKTHGNIQEIK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00110770;
90% Identity
-
80% Identity
-