Basic Information

Insect: Monochamus alternatus
Gene Symbol: NFIX
Assembly: GCA_037114965.1
Location: CM073432.1:25409225-25417644[-]

Transcription Factor Domain

TF Family: CTF_NFI
Domain: CTF/NFI and MH1 domain
PFAM: PF00859
TF Group: Unclassified Structure
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [2, 1, 5] (also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication [6]. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) [4]. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans [5]. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0045 1.2e+02 3.9 3.6 4 87 222 317 219 325 0.65

2 4 6.7e-11 1.7e-06 29.6 16.5 153 272 299 418 282 429 0.73

3 4 0.27 7.1e+03 -2.0 0.3 238 271 427 460 417 467 0.61

4 4 0.5 1.3e+04 -2.8 2.4 231 266 479 513 433 533 0.67

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0045	1.2e+02	3.9	3.6	4	87	222	317	219	325	0.65
2	4	6.7e-11	1.7e-06	29.6	16.5	153	272	299	418	282	429	0.73
3	4	0.27	7.1e+03	-2.0	0.3	238	271	427	460	417	467	0.61
4	4	0.5	1.3e+04	-2.8	2.4	231	266	479	513	433	533	0.67

Sequence Information

Coding Sequence: ATGTGCCCTAATTACCAGGACGAGTTCCATCCTTTCATCGAGGCCCTGCTGCCTTTCGTCAAGTCTTTTTCCTACACATGGTTTAACTTGCAAGCCGCTAAGAGGAAGTATTACAAAAAGCACGAAAAACGAATGTCTCTGGAGGAGGAAAGACAGTGCAAGGAAGCACTTCAGAATGAGAAAGCGGAAGTCAAGCAGAAGTGGGCATCCCGCTTGCTGGGTAAACTACGAAAAGACATTACTCAAGAATGCCGAGAGGATTTTGTGCTGAGTATAACAGGAAAGCGTCCTGCTGTGTGTGTCCTGTCCAATCCAGACCAGAAAGGCAAAATGCGCCGGATAGACTGCCTTCGCCAAGCCGATAAAGTTTGGCGTCTTGATCTCGTTATGGTGATACTATTCAAAGCAATACCTCTTGAGAGCACCGATGGTGAGAGGTTGGAGAAAAACCCAGACTGCTCGCAACCTGGACTGTGCGTGAACCCATATCATATTAATGTGTCCGTTAGGGAACTGGACCTGTATCTAGCTAACTTCATCAATAGTCACGaAATTTTAAGTGGTGTATGttacaataacaacaacaaaaaagaagaagaaaggaaaaataaagTTACAGGATACACCCACAATCCTTATAACGGAGTAGTATGTAATGACATTATATTAGCCACTGGAGTATTTTCATCAAAGGAATTATGGAAGTTATCCAAATcttCGATACTACACGAATTGTCAGATCCACAACCCAATATGAACAGCGTGAAGCTGGAACATCCTGctttttattgcaataattatCCCGAACAAGGACCCGTCGTTGCGGACCGATCATCGTCTGTAGACGCAATGGTCGTTTCAGCTACATATTCAATGCCTCAAAATACCACGTTAGTGTCTTCCAGTTCTCAAGCAAGTCCGAGTACGTTATTCTATCAGCATAGTCCAGAACCTCACCATCAGCACCAAAACCAAGTAAAATATCCGGAAAACGGCCACGACTCCCTCTCGGATTTTGTTACCTTTGTTTGTCAGGAAACGGACAGCAATCAAAACGCACAGATGCAAACTAACTTATCGAGAAGTCCGAAATCGCAATATTTCCCTTCGACTATGCTTCCACCGCCCCCTTTACCGCCGATGGCTCGACCAGTTGCCATAATCCGCTCAACTGGGGATGTAACGATGAGCGGGACCAATTCGCCTCCTGCCAGTATAACACCTCCATGTAGCGAAGCTTCACCGGCTGATGAAGTACCGGAAATAAGTTCTTCGCCGCCTTTAAGTCCTGGAAGCCACGAGAGGCGGAAATCGCCTTCACAGAGAAACTCAGTACCCACAAGCAGTCCGTACTCCCCCAGCAGAGACTATTCTTTCAACCACTTCCACGGGCAGCCGGGACATCTCTTCAGCTACCCCAGTATGACAGGGATGTCTGGCGTTATCAGTCCTACGAACCTCAGTATGTACTCACCCAGCGTGAGTACGTCGAGAGGCACTCCGCGTTCTAATAGTATACCGAGGTGGAGCACCCCTCTGTTCACATTAGACCAGGAAGACTTCAATATGATAACCCACCCCGCCAACCCCGAAACTAATGCAATAATCCTGATGGACGAGGCGACAGCTGCGGCGTCATCTGCGGAACATACAGGACAGTGTTGTAATAGTGCGAATCTGATGTGTGACGCGGACAGATTTTTCCAAGCAAACGACGCTTTAGAAAGTTCCGCTTCTCGAGAACCAGATCAATTACCCGCACCAAAGTCGCCATAA
Protein Sequence: MCPNYQDEFHPFIEALLPFVKSFSYTWFNLQAAKRKYYKKHEKRMSLEEERQCKEALQNEKAEVKQKWASRLLGKLRKDITQECREDFVLSITGKRPAVCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKNPDCSQPGLCVNPYHINVSVRELDLYLANFINSHEILSGVCYNNNNKKEEERKNKVTGYTHNPYNGVVCNDIILATGVFSSKELWKLSKSSILHELSDPQPNMNSVKLEHPAFYCNNYPEQGPVVADRSSSVDAMVVSATYSMPQNTTLVSSSSQASPSTLFYQHSPEPHHQHQNQVKYPENGHDSLSDFVTFVCQETDSNQNAQMQTNLSRSPKSQYFPSTMLPPPPLPPMARPVAIIRSTGDVTMSGTNSPPASITPPCSEASPADEVPEISSSPPLSPGSHERRKSPSQRNSVPTSSPYSPSRDYSFNHFHGQPGHLFSYPSMTGMSGVISPTNLSMYSPSVSTSRGTPRSNSIPRWSTPLFTLDQEDFNMITHPANPETNAIILMDEATAAASSAEHTGQCCNSANLMCDADRFFQANDALESSASREPDQLPAPKSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01163148;
90% Identity: iTF_01290001;
80% Identity: iTF_01014498;