Basic Information

Gene Symbol
-
Assembly
GCA_001014845.1
Location
JXPH01017071.1:2686-4914[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 1.1 45 5.0 0.2 2 23 153 175 152 175 0.95
2 12 0.55 23 5.9 3.5 1 22 240 261 240 263 0.90
3 12 1.1 46 4.9 1.2 1 21 356 376 356 377 0.94
4 12 0.46 19 6.1 2.9 1 23 410 435 410 435 0.91
5 12 0.00013 0.0054 17.3 1.7 1 21 451 471 451 472 0.96
6 12 1.8 73 4.3 1.0 1 22 479 500 479 502 0.86
7 12 0.02 0.82 10.4 2.0 1 23 508 530 508 530 0.88
8 12 2.8e-05 0.0012 19.4 0.2 1 23 537 559 537 559 0.97
9 12 5.9e-05 0.0025 18.4 3.3 1 23 565 588 565 588 0.98
10 12 0.037 1.5 9.6 1.8 3 23 596 616 595 616 0.96
11 12 0.00081 0.034 14.8 0.1 2 23 624 645 624 645 0.97
12 12 0.0017 0.069 13.8 1.4 1 23 653 676 653 676 0.94

Sequence Information

Coding Sequence
ATGTTAGACTTCGTGGCGCTCCGCAACGATTGTATCAACACGCAATTGGCGTTAGAAAAAATTGCTGCCCAAGATGCTTCATCTACCGAAATGACTTGTAAATTAGAAATCGAGTATTTATATGATGAATACGAGGTAGAAGGAGGATGCATAGACGCAGAGAAATTCGAATCCGTTGATCTTCCCCCTGTCGATAGCGATTCTGTCGATGAAGAACCCGTCATTGGCGAAGATCTGGTCAATGATGCTGCTGACGAACTCATCATTCCTCTATTCATCTGTTCCTCAGCACCTGATAGGTcacagaaaagaaaaagatcTCCACCACCTCCACCTGCAAAGGAAgaaccaaaaaaagaaattatttcacTTTCTACAGGAATAAAATTACAAGACACTGATTTGGGATGCAAACAGCCCCAATATAAGTATAAACACTATTCGCAGGCTGGGATAAAATGCTGTGGATGCGAAGCCGTTTTGAAAACAGAAGATGACTTAATACCACATTCCCGAACTGTGCACGAAccaaataaaaagaattttaacaAAAGGAAGAACCAGCAATGTTCGTTCTGCTTCCAGCTATTGAGTATTAATGATCCAACACTCGAAGATCACATCACAGTACAATATGAGTGCGACATGTGCGCTCTTGTCTACCATGACGTGCTCAGCTACGATGAACATCTTCAGAAATATCACCAGCAACTTGTGTTCAAGTGCTGCGGCTGCACCTTTGAGTGTGATACTAGAGAACAGCTGGAAAATCACTCAGAAGAAGTTCATCTGGAGCgccgaaaaaagtttttgggaaCATCCAAAGAATGCGAcatttgttataaaaaaattccacGAGATAACAAAATGCACGTCCACAAATCGCAGCCTTACCGACAAGCAGTTGAATTAAAGCACGTTGTAAAAACCGAGGCAAAAGAATATCTTCGTTGCTGTGGTCACAAATGCTTCCCAATTTTCGACGATGAGGAACAGCTGGTAGAACATTGCAGTGAAGTCCATTTGCCAAACAGAATTTTGGATGCAGATGcggacaaaaaaacatttgaatgcGAGAAATGTTACGGTCGTTTCTTGAATCTTCGATCCTTGAGAAATCACCAAAAATATAAGATGAAGAAACTGATAAAGTGTAGATTTTGTCCAGCGTACAAACAGAGTGCGGAAGAAGTAAAAATCCACGAGGAAATGCATAAAACAGCAGGCTTCAAATGTTGTGGACTGAGATGCGAAACCACTTGCTCAACGTACTCCGAATTGTTGGAGCACGCAAAGGAAATCCATTCTTCTAACAAGAAAATATATTGGTTCGAAAAAGAGGAGCGGGCATTTGAGTGTGAAATTTGTTATAAAAGCTATAAAGACAAACATTCTTTAAATACACATAAAAGAGGTCTTTATAGAGATTGTCGGTTCTTCTGCGACAAATGCTTCTTTAAAACTGCAACCCAGGCATCCCTAGATGCCCACAACGAGTTGAAACATGGTGAAGTAGGAAGTTATCCTTGTAAGTATTGTAAAAAAGTCTTCAAAAAAGAATTATTGCGCACTATGCACTCTAAAATACATGAGCAGAcagaaaaatcatttatttgtgAAATTTGCAATAAGGGATTTGCAAGACGTGCACTTTTAGTGTCCCATACTAAATCTCATTCGGCGGAGCGGAATTTCAAGTGTAAATTGTGTTCGTTGACGTACAAAAGAAGCTCCCATTTGTCTATACACGTAAGAAGAGCGCATTCAAAAGAGAAAAATGTGGCCTGTCGGTATTGTAAAAAGCTTTTCTATACCTCGTCGGACAGAAGAAAGCATGAGGGCACACATTCTGCAAGTTTGAAGACAAACGTTTGTAAATACTGTGGCAAAGCCTACACTATGAGATGGGATTACGTTGTCCACGTAGAAACGCATGTTCCAGATCTCGAAAAGAAATTCCCCTGCaacaaatgtccaaaaaagTTTAGCGAAGAAGGTTTTTTGGAGACGCATTTTAGGTTCAATCATTTGGAAGTTGCAGCAACGGCCAGCTCGCTTATGAAACAATGCTCTCAGCGACGTAAAACTAAGACAAAAGAGGAACCCTGTCTTGACATCAATGAAGACGATCAAGAAGTTGAGGATTATCTTTATGATGAAATTGGAGACCCCGTTGCTGCATACACAGTTATTGATGGAGAAGTTGTACAGGAGGAAGTTATAACGTGA
Protein Sequence
MLDFVALRNDCINTQLALEKIAAQDASSTEMTCKLEIEYLYDEYEVEGGCIDAEKFESVDLPPVDSDSVDEEPVIGEDLVNDAADELIIPLFICSSAPDRSQKRKRSPPPPPAKEEPKKEIISLSTGIKLQDTDLGCKQPQYKYKHYSQAGIKCCGCEAVLKTEDDLIPHSRTVHEPNKKNFNKRKNQQCSFCFQLLSINDPTLEDHITVQYECDMCALVYHDVLSYDEHLQKYHQQLVFKCCGCTFECDTREQLENHSEEVHLERRKKFLGTSKECDICYKKIPRDNKMHVHKSQPYRQAVELKHVVKTEAKEYLRCCGHKCFPIFDDEEQLVEHCSEVHLPNRILDADADKKTFECEKCYGRFLNLRSLRNHQKYKMKKLIKCRFCPAYKQSAEEVKIHEEMHKTAGFKCCGLRCETTCSTYSELLEHAKEIHSSNKKIYWFEKEERAFECEICYKSYKDKHSLNTHKRGLYRDCRFFCDKCFFKTATQASLDAHNELKHGEVGSYPCKYCKKVFKKELLRTMHSKIHEQTEKSFICEICNKGFARRALLVSHTKSHSAERNFKCKLCSLTYKRSSHLSIHVRRAHSKEKNVACRYCKKLFYTSSDRRKHEGTHSASLKTNVCKYCGKAYTMRWDYVVHVETHVPDLEKKFPCNKCPKKFSEEGFLETHFRFNHLEVAATASSLMKQCSQRRKTKTKEEPCLDINEDDQEVEDYLYDEIGDPVAAYTVIDGEVVQEEVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-