Basic Information

Gene Symbol
Zfy2
Assembly
GCA_001014845.1
Location
JXPH01015531.1:14594-17204[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.7 29 5.6 0.4 2 23 35 56 34 56 0.95
2 19 0.62 26 5.7 0.6 3 23 64 85 63 85 0.95
3 19 0.015 0.61 10.8 0.3 3 23 98 118 98 118 0.99
4 19 0.73 30 5.5 4.1 1 23 124 147 124 147 0.96
5 19 0.00065 0.027 15.1 0.1 1 23 182 204 182 204 0.96
6 19 3.7e-07 1.5e-05 25.3 0.9 1 23 210 232 210 232 0.98
7 19 6.8e-06 0.00028 21.3 0.3 1 23 238 261 238 261 0.97
8 19 0.18 7.4 7.4 2.6 1 23 305 328 305 328 0.91
9 19 0.022 0.92 10.3 0.2 3 23 370 391 368 391 0.95
10 19 1.5e-05 0.00063 20.2 1.6 1 23 397 419 397 419 0.98
11 19 0.011 0.44 11.3 1.6 2 23 425 446 424 446 0.97
12 19 0.00014 0.0057 17.2 0.2 3 23 454 474 452 474 0.97
13 19 0.007 0.29 11.9 6.6 1 23 480 502 480 502 0.98
14 19 0.0096 0.4 11.4 4.5 1 23 508 530 508 530 0.97
15 19 1.8e-05 0.00077 20.0 4.1 1 23 536 558 536 558 0.98
16 19 0.0007 0.029 15.0 4.1 1 23 564 586 564 586 0.98
17 19 0.00058 0.024 15.3 4.2 1 23 592 614 592 614 0.98
18 19 7.8e-06 0.00033 21.1 4.5 1 23 620 642 620 642 0.98
19 19 6e-07 2.5e-05 24.6 2.2 1 23 648 670 648 670 0.99

Sequence Information

Coding Sequence
ATGGAGTGTAATAAAGTTGGAACAGCAAGTGCAATAACAAAAACAGTGGAACAAAAGaagattaaaaagaaaatcaataaatcgattgatccaaaaaaaattagctgCTTGATTTGCAAAGCAATTTTCCTAAATGTTAAGTTGTATAAAAAGCATATGAGCTCTCATAATCAATCAGGAACAATTTTATGTGCAATTTGTAAGCTTAAATGCgaagatttcaataatttgcTGATGCACATTGATAGTGCACACGAGCAACAGATGACAAGGGACAACCCGGTGCTAGGTTGCAATATTTGTTCGgcaacttttccaaaaatcaaTACGCTAGAAAATCACGTTAGAAATCATTTGAACGAGGAGCCATATCGATGCCATTTATGtcaaaatcctttttattctaTAAACATACTAACTAAACATATGATGCATAACCATGAAGAGAATTTGAGgcatttttgtagattttgtgTTTATAATAGCGTGAATGATTCAGAAATCATTGAACATGAAGCTTCAATTCACACTAAAACTCTACCGTTTGATTGTTCAGAATGTGGAGAAACTTTTTCGATCGTAAAGGACTTGATGAACCATCGAATAATTCATAATTGTGATAAAAAGTATTCTTGCAACGATTGTGAACGTCGCTTCACAAGATCTGAAGATTTAAATTCTCATCTTAGAGTTCATCGAGGATTAGCTTGCTTTGAATGTGAATTTTGCGATCGTATATTCGCGCAATCGAAAAATCTAATCAATCACATTAAAAATGTGCACGGAAATAAACTTGATGAAGATGATCATTACTATTTAGACAATGGTTTTCTATTggataaaattccaaaaaataacgAGCCCGTTATTTTCGCGGCCTTCGAAAGGGAAGAAACTTTATATATACGAAGattcaaatgttttttgtgCGGATTAGCATTTATCAAAATGAAAACGCTGGAAATTCATTGCAAAAGAAATCATGATGGACTATACATTCACGAACAACTGAAGGAAATTGAAGAAAACGCTTTAGCAGAAACCGATTTAAGTAAATTTTCTGTTGCTGTGATAATTAGATCGCCCAACAGTGTAAGAAAGATTGATTGTTCTTCATGCAGTGAAAAGTTTTTATCCCAATCCGAATTAATTCAGCATATAAAAAGTGAACATAACGGTTCTAAACCTTATAAATGTACAAAGTGCAATATTTCTTTTGTACGTTCCAGCACTCTTGTCGAACATACTAAAAATCATTCAGAAAAACGAGTAAAATGCGAGTATTGTGGATTAACTTTCCAAATTGTTAACTCTCTCGTAAAACATCATAAGAAACATGTTGGGGATGCTGTTCAAAACTGCTCAATCTGCCAAATTCCATATGCTTCCCAAAAGGATTTGGATCGTCATATGCGAGTACATTCTTCGGGGAAACCTcacaaatgtaatttttgcGAAAAACGATTTGCCCAGTCCTgcgataaaataaaacatcaacGGATTCATACGAAAGATCGTCCGTATGAATGTGACGTTTGCCATAAAAAATTTGCCCATATTACGAGTATTAAAAAACATCGATTTGTCCACAATGAAGAGCGACCACACCAGTGTTTTGTTTGTGGAAAGTCGTTTCAACATAAAGgtaATCTAATTGTCCACAATCGAACACATTCTGGAGAgcgcccatacaaatgtaaaatATGTGGAAAATCGTTTTACGCTTCAGGTCACCACACTGAGCACATGAAAATTCATAGTAACGAAAAGAATTTTGTCTGCACGATTTGTAATAAGGCGTTTTTGCATCAAAGTAGCTTCAGGAAACACAAGCAAATGCATTCGGGAGAAAAGCCACACAAGTGCCAAATGTGTGATAAAAGGTTTTCTCAACCCGGACATTATCGAGAACATCTCAGAATTCATACAgGAGAACGTCCATACAAGTGTAATATATGCGAAAAAACTTTCAGGAGATCTGACGCATTAAATACGCACAAAAAGTCGCACACGATGACGGCAGATAATATTTCAAACCAGGAAATTAAAACGCTATTGTTAACCGAAGATATTGAGTTTAAACAGCAAGATATTGAAACTGAAGATCACATGATTGAATTGTCTGACACAGCAATTTTAGACAGCAATTCACAACTGAATTTGGGTTATGAACCTCATTTATACCTTGAAATGTCAGATTAG
Protein Sequence
MECNKVGTASAITKTVEQKKIKKKINKSIDPKKISCLICKAIFLNVKLYKKHMSSHNQSGTILCAICKLKCEDFNNLLMHIDSAHEQQMTRDNPVLGCNICSATFPKINTLENHVRNHLNEEPYRCHLCQNPFYSINILTKHMMHNHEENLRHFCRFCVYNSVNDSEIIEHEASIHTKTLPFDCSECGETFSIVKDLMNHRIIHNCDKKYSCNDCERRFTRSEDLNSHLRVHRGLACFECEFCDRIFAQSKNLINHIKNVHGNKLDEDDHYYLDNGFLLDKIPKNNEPVIFAAFEREETLYIRRFKCFLCGLAFIKMKTLEIHCKRNHDGLYIHEQLKEIEENALAETDLSKFSVAVIIRSPNSVRKIDCSSCSEKFLSQSELIQHIKSEHNGSKPYKCTKCNISFVRSSTLVEHTKNHSEKRVKCEYCGLTFQIVNSLVKHHKKHVGDAVQNCSICQIPYASQKDLDRHMRVHSSGKPHKCNFCEKRFAQSCDKIKHQRIHTKDRPYECDVCHKKFAHITSIKKHRFVHNEERPHQCFVCGKSFQHKGNLIVHNRTHSGERPYKCKICGKSFYASGHHTEHMKIHSNEKNFVCTICNKAFLHQSSFRKHKQMHSGEKPHKCQMCDKRFSQPGHYREHLRIHTGERPYKCNICEKTFRRSDALNTHKKSHTMTADNISNQEIKTLLLTEDIEFKQQDIETEDHMIELSDTAILDSNSQLNLGYEPHLYLEMSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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