Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.76 49 5.7 0.1 1 17 106 122 106 123 0.91

2 7 3.2 2.1e+02 3.7 0.8 1 15 132 146 132 147 0.80

3 7 0.0045 0.29 12.7 6.5 1 23 146 169 146 169 0.95

4 7 0.0027 0.17 13.4 0.3 1 23 175 198 175 198 0.95

5 7 1.9e-06 0.00012 23.3 0.2 1 20 204 223 204 225 0.94

6 7 1.1 70 5.2 4.3 1 23 233 256 233 256 0.89

7 7 0.00056 0.036 15.5 0.2 1 23 261 284 261 284 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.76	49	5.7	0.1	1	17	106	122	106	123	0.91
2	7	3.2	2.1e+02	3.7	0.8	1	15	132	146	132	147	0.80
3	7	0.0045	0.29	12.7	6.5	1	23	146	169	146	169	0.95
4	7	0.0027	0.17	13.4	0.3	1	23	175	198	175	198	0.95
5	7	1.9e-06	0.00012	23.3	0.2	1	20	204	223	204	225	0.94
6	7	1.1	70	5.2	4.3	1	23	233	256	233	256	0.89
7	7	0.00056	0.036	15.5	0.2	1	23	261	284	261	284	0.90

Coding Sequence: ATGGCCCATGGAGTGGTTGATTTTACAAAAGTATTCGTTAAAATCGAAGAGAACGTCGATATTCAATCTGAAATTATCGACATAGTGTCCGATGAGGAAGTATGCGAGGAGGAAGTTAGATTCATCAAACCGGAACCATGCGTTGAAGAGCCGATCGAGAGTAAACAAACAAAAGTAATCGTTCAAATCGAAGATAACGTCGATATTAAATCTGAAATTATCGAGATAGTTTCCGATGAGGAAGTATGCGTGGAAGAAGTTAGATTCATCAAACCGGAACCCTGCGTTGAAGAGCCGATCGAGAGTCTCATCAGATTTCGCTGTGTTAAGTGCGGTTATATCGCTGATACGAAGGAATCCCTGCGCGCTTGCCTCGACAAGAATCTTGTAGAGTTCGTATGCGATAAATGCGAAAAACGCGGAAATAAAAACGCTCACTTTTGTAAGAAATGTAAGTGCGCCTTTACGCGAAAGACCAGTTTGACAGGGCACGTTTGTACGCCTCACCGCGGAAGAAGAGAATACAAATGCGAGCTTTGCAATATGGCATTTTTTAATGGAGTTTCTCTGAAAATACACGTAAAATTCGCTCATGAACAGCTGAAGCATTATGTTTGCGCGGAGTGTGGCCGCGCGTTCAAGCGAAAATATGAACTAAATAAACATACCGAATCGAGTCAGTCTGCATTGAGAAAATTTGCCTGCTCGCAATGCTGTTGCGCTTTTACTAGCCAACAGAGTTTGAAATTACACACATACGGCATCCACTTAAAACTAAGATACAACTGTGATCTGTGCAGCAGTACTTTCTCTCGGCAGGGAGGGCTAACAAAACATGAAATCGCTGCGCATCCCCATGACTGA
Protein Sequence: MAHGVVDFTKVFVKIEENVDIQSEIIDIVSDEEVCEEEVRFIKPEPCVEEPIESKQTKVIVQIEDNVDIKSEIIEIVSDEEVCVEEVRFIKPEPCVEEPIESLIRFRCVKCGYIADTKESLRACLDKNLVEFVCDKCEKRGNKNAHFCKKCKCAFTRKTSLTGHVCTPHRGRREYKCELCNMAFFNGVSLKIHVKFAHEQLKHYVCAECGRAFKRKYELNKHTESSQSALRKFACSQCCCAFTSQQSLKLHTYGIHLKLRYNCDLCSSTFSRQGGLTKHEIAAHPHD

Sequence clustering based on sequence similarity using MMseqs2