Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.4e-06 0.00022 22.5 0.2 3 23 85 106 83 106 0.94

2 6 1.2e-05 0.00077 20.8 0.8 1 23 112 135 112 135 0.89

3 6 3.5e-05 0.0023 19.3 0.2 1 21 141 161 141 164 0.90

4 6 6.3e-05 0.0041 18.5 0.3 1 21 170 190 170 193 0.90

5 6 1.3e-05 0.00082 20.7 0.1 1 22 199 220 199 222 0.90

6 6 1.6e-06 0.0001 23.5 2.0 1 23 228 251 228 251 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.4e-06	0.00022	22.5	0.2	3	23	85	106	83	106	0.94
2	6	1.2e-05	0.00077	20.8	0.8	1	23	112	135	112	135	0.89
3	6	3.5e-05	0.0023	19.3	0.2	1	21	141	161	141	164	0.90
4	6	6.3e-05	0.0041	18.5	0.3	1	21	170	190	170	193	0.90
5	6	1.3e-05	0.00082	20.7	0.1	1	22	199	220	199	222	0.90
6	6	1.6e-06	0.0001	23.5	2.0	1	23	228	251	228	251	0.92

Coding Sequence: ATGAGTGGGCAAATTGTGGACGATTACGGCAACATTACTGTCAAGATGGAAGAAAAAGTAACGATTAAAATAGAAGTCAATTCTAACGATTCTGATTCAAATATTTCTCTAAACGATTTCATACAGGATGAGAAAGGGACTGTGGTTCAATTTTATAAAGAAGAGGCTTGTTTCATAAAGCCAGAAACAATAGAAAGTGGGCCATCTGGAAGTAGTAATATTGTAGACGATGTGCGTGTCAAATCTGATGCTTGCTTGAAATGCGACAGGGCGTTTTCGTATAAAAGTGATTTAAATCGACACATCAATGAGATTCATTTGAAATTAAAGAATTTTTTTTGTGGTGAATGTGACCGTTCTTTTACAAGGCAAGACCATTTGAAAGGACACGTAGACGCAGTTCACAGAAAATGGAAGAAATACTCATGTGGAGAATGCGATCGTGATTTTGCACATCAATCGGCTTTGAAACAACACGTAGTCGCAGTTCACAGGAAATTGAAAAAATACTCATGTGTAGAATGCCATCGTGCATTTACAGAGCAAGGAAGTTTGAAAAGACATGTGGTGGCAGTTCACAAGAAATTGAAGAAATACTCATGTGGAGAATGCGATCGTGCTTTTACAGAGCAAGGTAATTTGAATAAACATGTAGTCGAAGTACACAGTAAATTGAAGAAGTATTCATGTGACGAATGCGATCATGCATTTACAAGGCAAGACCATTTGAAAAAACATTTGGATGCCATTCATCGGAACATAAATTTGAATCTTATGCTCAATGTCGTAGCCAAGAAGAGATCGGTGAGGTTTGATGGGGACAGTGCCGGCCCGAGGTTAGTTTTAGGATGGAGCGAGTTCTAA
Protein Sequence: MSGQIVDDYGNITVKMEEKVTIKIEVNSNDSDSNISLNDFIQDEKGTVVQFYKEEACFIKPETIESGPSGSSNIVDDVRVKSDACLKCDRAFSYKSDLNRHINEIHLKLKNFFCGECDRSFTRQDHLKGHVDAVHRKWKKYSCGECDRDFAHQSALKQHVVAVHRKLKKYSCVECHRAFTEQGSLKRHVVAVHKKLKKYSCGECDRAFTEQGNLNKHVVEVHSKLKKYSCDECDHAFTRQDHLKKHLDAIHRNINLNLMLNVVAKKRSVRFDGDSAGPRLVLGWSEF

Sequence clustering based on sequence similarity using MMseqs2