Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 8.7e-06 0.00053 21.4 1.6 1 23 61 84 61 84 0.92

2 6 0.001 0.061 15.0 0.0 1 23 90 113 90 113 0.96

3 6 6.5e-05 0.004 18.7 0.1 1 23 119 142 119 142 0.94

4 6 1.7e-05 0.001 20.5 0.2 1 23 148 171 148 171 0.96

5 6 9.3e-06 0.00056 21.4 0.3 1 23 177 200 177 200 0.94

6 6 5.3e-06 0.00032 22.1 0.3 1 23 206 229 206 229 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	8.7e-06	0.00053	21.4	1.6	1	23	61	84	61	84	0.92
2	6	0.001	0.061	15.0	0.0	1	23	90	113	90	113	0.96
3	6	6.5e-05	0.004	18.7	0.1	1	23	119	142	119	142	0.94
4	6	1.7e-05	0.001	20.5	0.2	1	23	148	171	148	171	0.96
5	6	9.3e-06	0.00056	21.4	0.3	1	23	177	200	177	200	0.94
6	6	5.3e-06	0.00032	22.1	0.3	1	23	206	229	206	229	0.97

Coding Sequence: ATGAGTGGAAAAAGTGTTGATATCGACGATTGTGGCGTAATTGTGAAGATTGAACCAAGTAACTCCGATGAGGCTATAACACCAGATGGAAGTAGTAACGTTGTCACATTCTACGAAGGAGTGACAAGCTTCACCAAACCAGAACCAAAATCAGAAGGTGAGCAAAAACATGTCAACAAATTCGTTTGTTGGCAGTGTGACAAGGCGTTTTGTCACAAGGGTAACTTAAGGCAACACGTCATAGCCGTTCACTTGAAACTAAAGGAATTCGTATGCGCGGAATGTGACGGTGCGTATTCCTCACTGGGCCATTTGAACGTTCATATAGACGTCGTTCATAAAAAGTTGAAGAAGTTTACGTGCAACGTGTGCGAGCGGGCGTTCGCAAAGGGATCAgatttaaagagacatttagaAGCCGTCCACTTCAAAATCAAGAAATTCGCGTGCGAAGAATGTGATCGCTCATTTGTAGTAAGAAGCAAATTAAGAATTCATGTTGAAACCACTCATAAGAAAAATGACATGTTTGTATGTGTGAAATGTGATCGTTCATATACCTCTCAAGATAGTTTAAATCAGCACATAGACAATATCCATGGAGAATTTAAGAAATTCGCATGTGGCGAATGTGATGGAAGATTTACTCAGAAAGTGTCCTTGAAGAGACATATGGAAACGGTTCATCGGAAAATCAAGAACTACgagAGTTCTTTCGTCGTTTCCGCCACGTCTAGCAATAGAGTGTCAACATCGACATCGAACCACGTTGCGAGCTGTCGAGAGAAAAACTCGTTCAATGATTTGGGTTTCGCCGCGTCATAA
Protein Sequence: MSGKSVDIDDCGVIVKIEPSNSDEAITPDGSSNVVTFYEGVTSFTKPEPKSEGEQKHVNKFVCWQCDKAFCHKGNLRQHVIAVHLKLKEFVCAECDGAYSSLGHLNVHIDVVHKKLKKFTCNVCERAFAKGSDLKRHLEAVHFKIKKFACEECDRSFVVRSKLRIHVETTHKKNDMFVCVKCDRSYTSQDSLNQHIDNIHGEFKKFACGECDGRFTQKVSLKRHMETVHRKIKNYESSFVVSATSSNRVSTSTSNHVASCREKNSFNDLGFAAS

Sequence clustering based on sequence similarity using MMseqs2