Basic Information

Gene Symbol
zld
Assembly
GCA_000572035.2
Location
NW:188399-197046[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.018 1.3 9.0 6.1 1 23 27 49 27 50 0.94
2 7 0.00086 0.061 13.2 0.0 2 23 221 243 220 243 0.95
3 7 0.0015 0.11 12.4 2.9 1 23 454 478 454 478 0.92
4 7 0.3 22 5.2 4.0 3 23 902 923 900 923 0.90
5 7 0.0019 0.13 12.1 3.9 1 23 929 951 929 951 0.98
6 7 6.9e-05 0.0049 16.6 5.8 1 23 957 979 957 979 0.96
7 7 4.5e-06 0.00032 20.3 1.2 1 23 985 1007 985 1007 0.97

Sequence Information

Coding Sequence
ATGAGTGAAATGACGAGTGTagagcagcagcagcagcaacagcagcagcaataTGTTGGTGGAAGCTCAAATTCAGAGCATCACTGCAAAGACTGTCGATTAACCTTCGAGAGCGGTAAAAGTCTTGAGGTACATTTACGGTATCATCACGAAAATCTGCTGAATCAGTGGGCCATTCAGGCTCAACAGGAGGagagcaataataataatagcaaagCTGGTAATCATAACAGTCACGTTAAACGCGATAGTATAACTGCACCAGCTGATTCAAGTGAATCTTCATCTCGGCCACCGTCCTCAAATCCTACGCCTTCTCAAcatcaacagcagcagcagcagcagcagcagcagcagcagcaacaacaacaatcacAGCAACAAACTGCCCAGACAGCTACATCATCTCAACAGCAACCACCACCCGGTGTGCAAGGTTATAATCACTTTCCGACACCGATGTTTAGTGAAACGAGTTACTTTATGCATAATGAACAAGCTTATATGCTACCAGGGCATCATTACTCACCCACCCACGATGATAGTCCAAACAACAGTAGCAGCAATTATGCTCCAAGGTATCATCCGTATCAGCATTCACATCATTATCCGGGTGATCGAGCTAACTCTGTAAGTTCAACGAGTCCACGCAGTCCATTGCAGTGTGACAAGTGTGGAGGAGTATTTGATGATGCCAACCAACTCGCTGAACATGTTCGTGCTAATCATCCAACTTCGCCGAGTGGATATCCAGGACAACAACAGTATCAACAGATTGGTGAAAGTCCACAGCAATCACAACAACAACAGTTACATACATCACCttcacaaaataatcaacagCCACAGCCATCATCTCAATCAAGCTTTGATTATAATAGAGGTAGTGTAACAATTAAATCAGAGATAAAACAAGAAACAGAAGAAGCTGAAATTCTGGATCTTGATTCGCATAAAGTGCAAACTCACAGATACGAAGAAGAGTTAATGAGGATGCAACATCAAGAATTGCAATTGCttcaacaacagcagcagcatccAATACAGCATCCGAGAAATCCTCCTCATTCTGTAAGCTCCATGCTTGGGTGGCCACCAGGACAACCGCACGAATATCATCCAGGTATGTCACCATTGGGTCCTATGGATAGTATATCACCGATACCAGATCAAAGTACATTTATGCGTGGGCAACATATGCCAGTAGAACCACCTCGACATGCTGGATCGCCAATTATAACAAGCACTCAACCTATGCCAGGTCATCCAATGCCAGGAAGTTTATTACAGCAGCCTCAAAAACCTCCTATAGTAGCTAACCAGTCGTGGAAGAGCAATGAGGCGCGTAGACCAAAGACCTATAACTGTACTGCATGCAACAAGTGGTTTACAAGTTCGGGCCATTTGAAGCGACATTACAATACAACGTTACATAAAAACGCTGTAAAACAGAGTAACCAACCAGATCCTGCAAATATGCCAATCAGTGCCCATCATCATCCAGGTAGAGATAACAATAGAGGAGGGGGAGGAGGATCATCGAGGTCGCCGGAGTTGTCCACTTCAGCGAGTCCCCCAAACTTGATGGCAGGTCCCTTGGGCGAGGCGGCGAGGGGCCTGCTCCACACGCCCACCAATCTCTACACCACCAATCATTCCAGCAACAGCAGCaccaacagcaacagcagcgaCTCTTCGGCAACGGTGTTACCGCAGCAGCCGCAGCAGCATCCGTCATCCCAACAGCCGACATCTACAACGGCTCACATGGGCTCAACAATGGCGGGGCTCAATTCCCCAACGCAATCCCCAATGGCGGGACACCATCACCAGCAACTGGGTTCACCATCCCCTCAGTTGGGCCAACACCACCTATCAATAGGTTCACCACCTCAAATGTCGGTCCACCACTCCATGAGTTCACCCATGTCACCCATGCAGCCACCACCGCCTCCACATCACCTGAATTCGCCTTCGTCAATGGGATCCCAACACATGAGTTCCCCATCGCCCATGATGGTGGGGGTGCCCCCAATGGGTTCACCACCAATGGGGGGTACTTCGATGCCTCATCAGCCGTACCCAAACGATTTGCCCCCCCACGTTACAACTACTACCAGCATCCCGGGCCTGCTGGACTCTATCAACCAGCAAACTATTATTGGTAATGAAGTAACAACTCAATCAATTCTTCATGAGTCACAATTACCCGGATTTGCTACTATTAGTCATCCAAGACCTCTGCCAAAGCAGAGCTTTTTTCAATACCATGTAACTGATTATTTAGTTGGCCCAAACCAACCTCAGGCCATTAACGTGGGGGGGCTAAGACCAGAGGATGAAATTCCTCATGACAGGTCATTCAGCTCAGCTAGTGCGATTTTCGATCCATATAATTCACCACCAAGGTACGAACCTCTGATGTCTATTGAGCATCAACATGAATCACATGCCGATGATATAATTGCAAAACATTATCAAATATTGGATAATAATTCTTCTTATCAAGATCATCATGTTACTGAacaaaataacaatgatattCCTCATTACCAAGgcaaagaagaaataaatccTAACGTTGGTaaacaaaatcaaaatgaaacaaaaaaacagaaaaCGACTATAGTACaggaaaaaacaaaagaacATCAAGTCACCAGTTcagatacaaattttatatctcaggAGGGTTTAATCACCTGTATCAAGTGCAACAAGGTTTTTAATAAGACCTGTTACTTGACACAACATAACAAGAGCTTCCACTCTGGCGAGAAGCCCTACAAATGCAGTCAATGCGGCAAACGGTTTCCCCATGAGGAATCGCATGCCGAGCACCTGCGAAAGCATGCTGGTGAGAAACCTTACAAGTGCGAGATTTGCCCGAAGCAGTTCAATCATAAAACAGACCTCAGGCGGCACAATTGTCTCCACACTGGCGAAAAACCATTCGCATGTGAGATTTGCAACAAAGGATTCATCAGAAAAGATCACATGATGAAACACGTTTTAACGCACAAAAGAAAAGCTATGAATAATTTACGtttacgataa
Protein Sequence
MSEMTSVEQQQQQQQQQYVGGSSNSEHHCKDCRLTFESGKSLEVHLRYHHENLLNQWAIQAQQEESNNNNSKAGNHNSHVKRDSITAPADSSESSSRPPSSNPTPSQHQQQQQQQQQQQQQQQQSQQQTAQTATSSQQQPPPGVQGYNHFPTPMFSETSYFMHNEQAYMLPGHHYSPTHDDSPNNSSSNYAPRYHPYQHSHHYPGDRANSVSSTSPRSPLQCDKCGGVFDDANQLAEHVRANHPTSPSGYPGQQQYQQIGESPQQSQQQQLHTSPSQNNQQPQPSSQSSFDYNRGSVTIKSEIKQETEEAEILDLDSHKVQTHRYEEELMRMQHQELQLLQQQQQHPIQHPRNPPHSVSSMLGWPPGQPHEYHPGMSPLGPMDSISPIPDQSTFMRGQHMPVEPPRHAGSPIITSTQPMPGHPMPGSLLQQPQKPPIVANQSWKSNEARRPKTYNCTACNKWFTSSGHLKRHYNTTLHKNAVKQSNQPDPANMPISAHHHPGRDNNRGGGGGSSRSPELSTSASPPNLMAGPLGEAARGLLHTPTNLYTTNHSSNSSTNSNSSDSSATVLPQQPQQHPSSQQPTSTTAHMGSTMAGLNSPTQSPMAGHHHQQLGSPSPQLGQHHLSIGSPPQMSVHHSMSSPMSPMQPPPPPHHLNSPSSMGSQHMSSPSPMMVGVPPMGSPPMGGTSMPHQPYPNDLPPHVTTTTSIPGLLDSINQQTIIGNEVTTQSILHESQLPGFATISHPRPLPKQSFFQYHVTDYLVGPNQPQAINVGGLRPEDEIPHDRSFSSASAIFDPYNSPPRYEPLMSIEHQHESHADDIIAKHYQILDNNSSYQDHHVTEQNNNDIPHYQGKEEINPNVGKQNQNETKKQKTTIVQEKTKEHQVTSSDTNFISQEGLITCIKCNKVFNKTCYLTQHNKSFHSGEKPYKCSQCGKRFPHEESHAEHLRKHAGEKPYKCEICPKQFNHKTDLRRHNCLHTGEKPFACEICNKGFIRKDHMMKHVLTHKRKAMNNLRLR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00380647;
90% Identity
iTF_01006577;
80% Identity
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