Basic Information

Gene Symbol
L
Assembly
GCA_000572035.2
Location
NW:1724535-1733320[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 7.9e-07 5.6e-05 22.7 1.1 1 23 99 121 99 121 0.98
2 17 0.35 25 5.0 3.9 1 23 127 149 127 149 0.97
3 17 1.4e-06 0.0001 21.9 2.5 1 23 155 177 155 177 0.99
4 17 5.9e-05 0.0042 16.8 0.8 1 23 183 205 183 205 0.98
5 17 8.8 6.3e+02 0.5 0.1 9 23 292 307 284 307 0.83
6 17 0.078 5.6 7.0 0.1 2 22 385 405 384 407 0.86
7 17 0.32 23 5.1 0.3 3 23 447 467 446 467 0.96
8 17 0.0052 0.37 10.7 1.2 3 23 481 501 479 501 0.96
9 17 0.0093 0.66 9.9 2.4 1 21 513 533 513 536 0.90
10 17 0.043 3.1 7.8 0.2 1 23 541 564 541 564 0.92
11 17 3.3 2.3e+02 1.9 0.1 9 23 597 612 595 612 0.87
12 17 0.02 1.4 8.9 4.8 2 23 662 683 661 683 0.97
13 17 0.0019 0.14 12.1 0.1 1 23 688 711 688 711 0.95
14 17 0.011 0.81 9.6 0.7 2 23 782 805 782 805 0.95
15 17 5.3e-05 0.0038 17.0 0.7 3 23 827 847 825 848 0.94
16 17 0.092 6.6 6.8 0.1 2 22 859 879 858 881 0.84
17 17 0.0062 0.45 10.5 0.4 1 23 1238 1261 1238 1261 0.95

Sequence Information

Coding Sequence
atgttatttaaggGAAATAGTTCaagattagaatttttaattgaaaaaattcaagcgCATAAAGAATTATCGCCGTCACCGCTTCCAGATGACAAGTGTACTTTAAGATCAAGagAAGGTCTGTTGAGTGGAATTTACTCATGGCGTAGCGAAGACGACAGTCTTAATGGACAGAGAGGTGGTGGGACACCATCTTCTTGCACAACTTCGACGTCGCTGAGTTTCCCCTCGGAAACTGAGACTGATGTtgacgttaaattaaatagtattgACGGCAGCATCACTTCTGGCCCATACCCGTGccaattttgtgataaatcttTTCCCAGTTTGAGTCAGCTGAAAAAACATGAACAGacTCATGGTGATCAAATGCCGTATCGTTGCAGCTGGTGCGCGcgattatttaaacataaacGCAGTAGAGACCGTCACGTAAAATTGCATACCGGCGACAGAAGATATCGATGTACTCGATGTGAAGCTGCGTTTTCTCGAAGcgaccatttaaaaattcacatgaAAACTCACGATAATCAGAAGCCATATCACTGCAGCGAATGTTCGCGGGGTTACAATACAGCAGCAGCATTAACGTCGCACATGCAGTCACACAAGCGTCCTCACtcattacaattacaattaaataatcatctcTACTCATCCCCTAAAACCGGCGAGACTGAGCGCAATTCGCTTTGGGCAAGTCGGGGATCTTCGCCTAGTGTTAGCTCACCGTTACCTTTGTCATCCTCAATGCCTATGCATAAATTAACATCCTATTCACCAGACTCTTCAGCCAACGAGTCATCATCCGCAGTATCCTTCTTGCGGTCGTCATTAACACTCGCCTGCATGTACTGTGCCAAAGATACGTTTACCAGCATGGAACAGCTTCAATTGCACGTTCAAGCTGTCCACGAGCTCAATATAAACAACAATCCGCTAAATAATCTAAGCAGTCCATCATCATCGCcatcaacagcaacagcaacgtCAACgtcaaataaaatagtagacaataattacaagcgtcgtaaaaaaaaagaagacttTAAAGCAAAAGATGATCCCACTAAAGTACATCgcagtaataatgataaagttgctattaataataataatgatacatCAGTATCAGCGTTGATGTTAACGTGTCCTTTGTGTGGGATATCATGTTCGTCCCCGACAGTCTACGCCGAGCATTACGTGCTCGAACACTGCGAAAATCGTAAAGTTGTTGCTGATAAAATGactgatgacaaaaaaaattatgaaaaaaaaatgatgatgagTAATAACTTGACTGCAGACGTTTATTCCTCAAGTACTTTATTGTGCGGGCAGTGCGGCGCGGCATTGAAAGACTTTGAGTCCTTTCGTGTTCACTTGGCGcatcatttgaaaataaacaacTACCAGAAGCAATTAAACGTCAATTGCCCAAAGTGTGAACTGAATTTTCACACTCAAGATGAGATGATTAATCATCTGACGAAGCACTACTTGAATGATAGTAATATAATTAAGCAGCGTTACTGTTGTGATGGATGCGATAGATATTATTTTGACGCGGAGTCGCTTAAAAAGCACACGTTTGATGAGCATACGCAGCAATTGTACAGATGCGCTGTTTGCAGAGAGACCTTTGAGTCGTCAGTCGCTATTCAAGTGCATTTCACTGTTAAACACACACGAGAGTGCACTGTTTATCAATGTACTGACTGCATAAATAATCCAGGGCGCGCCAAGAGTAATGAGACGCGGGACAACAATGGGGtggattgtttttttaaaacttgtacGGAACTGATGAAACACGTGATTAATGCTCATTTATCGTCCTCGTCATTATCCTCGTCGTCATCGTCATCATTGTCCTTGTCATTGTCGTTATCGTCTGCGCAAGAACAAGATCGAATTACTCAAATGAGTTGTGGAATCGCTCAAGACACAACGAGAGTCTGcggtgaattatttttacgatGCTGTTTTTGTGGTGTACATTGTAATACAGAGGGTGATTTACAACGACACTTGGCAACCCACTCGACGTGCCTTTATAGATGCCCGATTTGTCGTCAAGGTTTTACTGTTGAATTTTTGCTGGACAAGCACATTGCTCAGATACATAACAATAATTcagctgctgctgctgctgctgttgataGTGTCTCgactactgctgctgctgctgataCTATGATAGATAGACATAATATTGTTAATCATTATAAAGTACAAGATGAGatgagatataaaagaaaacattCGTCGCCTGAATTAATTCAACAAAATCAATCAGATCATCGTTTATCAAACCaaaatgaattaaaaataaatcgctGTGAATATTGCGATCGGAAAGATTTTACAAGTGACTCAGAGTTACGCGCGCACAAAAAACTTGCCCacaaatcatcatcatcatcatcgttaGCAAAAGTAAATCAAACAAAATCGCTATCGCAGCAAATCTGTAGTTACTGCGGTGAATCAACGCGTTCACGTGGTGAATTAGAAGCTCACACAAGATTGCACCACGCGCCGAATGAATTAGCGAAGCGTCGTTTAAAGTGTAACATTTGCgatgaattattttcgacAAGTGGTATTTTAGCAGAGCATAAATTAGATAAAcattgcaaaataaaattgagcgACGTGTGCATCGTCTGCAGAGTCGTGCTACAAAGTGAAACAGATTTTATTGAACACGTACAGAAGCATAGTTTAGAATCGATTGATTCACATCAACAGAGACACGATGGTTTACTTTCAGCTCCTATTTCAGCAACAACTCAAACAGTTTCTCTTCCAACTAGTACTCTTACTCCTAACTCTAACACTAATACTAATACTAGTTTTAGTTCTAGCACCAGTATTAGTATTACAACTTCTGGCAGTACTCATGTCCCCGTTTACTGTGTTGTCTGCAGGCAGACTCTCATTAGCGAGTTCGATTGTCAATTACACGCCAAGTATCATTTACGATCACAATCTTCACTtgattctaattttatttctgttaataataataataataataaattaaattgttgcatttgtttacgagaatttgataatgataattctGTTATACCTTTGTCAGGAAATAGTTATGATATAGCAATTAGCGAACGTAAATTGAATGTCTGCAACAGATGTTACGTCAGACATTTGAACGGTTTGCCCATTttaggtaataatttttataataataatgataatgatgatgataaatttataaacgaaAATGCTGATCATGGTGATCATGGTGTTGATAATGAATATGAGACAAAGTGTATTAAATTAGAGAGTATGAATGATAatgaagatgatgaaaataatgataatgatgatgataaatttataaacgaaAATGCTGATCATGGTGATCATGGTGTTGATAATGAATATGAGACAAAGTGTATTAAATTAGAGAGTATGAATGATAatgaagatgatgaaaataatgataatgataatgacaacgatgatgatgatgatgaagatgaagatgaagatgtTAATGTGGATGTTGATGTTGACGTTGATGTTAATAATGAGTATGAGGGGCTGGGCAAAGACAAAGATGATAAACAAGGAGAAAACAAAGTGGAGGATAAGGAGGATGAGAATAAGAAAGGAGAGAATGATAAGAATAGTGTTTGTAATGATAAGAATAAAAGTAGTGCTGGCGTCCGTCCATATAACTGTCCTCAATGTACCCTCTTGTTTGCTTTTAAAGTTGAATTGGAGCATCACCTTAATGCTGtacatatgaataaaaatatgtcttgTATGGTTAATGCTACACCGAGGgagaataaatttactaaagtaGTTGGGAATTATCCTGATGTTAATGTGAAGGACAATGTGAGCGAACAAGAGGGTAAGGTTGTTGTAAAAGAAGAAGTTGTTAATAATGAGCCgactaatgattttaaaaaAGATCCAAAGACTTTTTCAGACAaaagtccgaaaaattttcaccagGGAAACTAG
Protein Sequence
MLFKGNSSRLEFLIEKIQAHKELSPSPLPDDKCTLRSREGLLSGIYSWRSEDDSLNGQRGGGTPSSCTTSTSLSFPSETETDVDVKLNSIDGSITSGPYPCQFCDKSFPSLSQLKKHEQTHGDQMPYRCSWCARLFKHKRSRDRHVKLHTGDRRYRCTRCEAAFSRSDHLKIHMKTHDNQKPYHCSECSRGYNTAAALTSHMQSHKRPHSLQLQLNNHLYSSPKTGETERNSLWASRGSSPSVSSPLPLSSSMPMHKLTSYSPDSSANESSSAVSFLRSSLTLACMYCAKDTFTSMEQLQLHVQAVHELNINNNPLNNLSSPSSSPSTATATSTSNKIVDNNYKRRKKKEDFKAKDDPTKVHRSNNDKVAINNNNDTSVSALMLTCPLCGISCSSPTVYAEHYVLEHCENRKVVADKMTDDKKNYEKKMMMSNNLTADVYSSSTLLCGQCGAALKDFESFRVHLAHHLKINNYQKQLNVNCPKCELNFHTQDEMINHLTKHYLNDSNIIKQRYCCDGCDRYYFDAESLKKHTFDEHTQQLYRCAVCRETFESSVAIQVHFTVKHTRECTVYQCTDCINNPGRAKSNETRDNNGVDCFFKTCTELMKHVINAHLSSSSLSSSSSSSLSLSLSLSSAQEQDRITQMSCGIAQDTTRVCGELFLRCCFCGVHCNTEGDLQRHLATHSTCLYRCPICRQGFTVEFLLDKHIAQIHNNNSAAAAAAVDSVSTTAAAADTMIDRHNIVNHYKVQDEMRYKRKHSSPELIQQNQSDHRLSNQNELKINRCEYCDRKDFTSDSELRAHKKLAHKSSSSSSLAKVNQTKSLSQQICSYCGESTRSRGELEAHTRLHHAPNELAKRRLKCNICDELFSTSGILAEHKLDKHCKIKLSDVCIVCRVVLQSETDFIEHVQKHSLESIDSHQQRHDGLLSAPISATTQTVSLPTSTLTPNSNTNTNTSFSSSTSISITTSGSTHVPVYCVVCRQTLISEFDCQLHAKYHLRSQSSLDSNFISVNNNNNNKLNCCICLREFDNDNSVIPLSGNSYDIAISERKLNVCNRCYVRHLNGLPILGNNFYNNNDNDDDKFINENADHGDHGVDNEYETKCIKLESMNDNEDDENNDNDDDKFINENADHGDHGVDNEYETKCIKLESMNDNEDDENNDNDNDNDDDDDEDEDEDVNVDVDVDVDVNNEYEGLGKDKDDKQGENKVEDKEDENKKGENDKNSVCNDKNKSSAGVRPYNCPQCTLLFAFKVELEHHLNAVHMNKNMSCMVNATPRENKFTKVVGNYPDVNVKDNVSEQEGKVVVKEEVVNNEPTNDFKKDPKTFSDKSPKNFHQGN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01006569;
90% Identity
iTF_01004603;
80% Identity
-