Basic Information

Gene Symbol
-
Assembly
GCA_000572035.2
Location
NW:3041280-3074033[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 38 0.02 1.4 8.9 0.9 1 23 302 324 302 324 0.91
2 38 0.079 5.7 7.0 1.8 1 23 350 373 350 373 0.95
3 38 2.1 1.5e+02 2.5 5.0 2 23 483 504 482 504 0.97
4 38 0.015 1.1 9.3 1.8 2 23 515 537 514 537 0.94
5 38 0.065 4.6 7.3 1.3 1 23 547 570 547 570 0.96
6 38 1.3e-05 0.00093 18.9 1.6 1 23 576 599 576 599 0.96
7 38 0.037 2.7 8.0 0.8 3 23 606 627 604 627 0.94
8 38 0.00031 0.022 14.5 1.5 1 23 632 655 632 655 0.97
9 38 8.1e-08 5.8e-06 25.8 0.7 2 23 662 683 662 683 0.97
10 38 4e-06 0.00029 20.5 0.6 1 23 689 711 689 711 0.98
11 38 1.1e-06 7.9e-05 22.3 0.1 1 23 717 739 717 739 0.98
12 38 0.071 5 7.1 0.1 2 23 1150 1172 1149 1172 0.91
13 38 0.74 53 3.9 0.3 1 23 1184 1207 1184 1207 0.95
14 38 0.04 2.9 7.9 5.1 1 23 1220 1243 1220 1243 0.94
15 38 0.00047 0.034 14.0 5.4 1 23 1249 1271 1249 1272 0.95
16 38 0.055 3.9 7.5 0.5 3 23 1279 1300 1277 1300 0.94
17 38 0.0012 0.088 12.7 0.4 1 23 1305 1328 1305 1328 0.97
18 38 6.6e-07 4.7e-05 23.0 0.4 2 23 1335 1356 1334 1356 0.96
19 38 6e-07 4.3e-05 23.1 0.7 1 23 1362 1384 1362 1384 0.96
20 38 5.4e-05 0.0039 16.9 1.7 1 23 1390 1412 1390 1412 0.98
21 38 6.9 4.9e+02 0.9 0.3 1 11 1522 1532 1522 1536 0.86
22 38 0.29 21 5.2 0.2 2 23 1554 1576 1553 1576 0.90
23 38 0.028 2 8.4 4.7 1 23 1581 1604 1581 1604 0.98
24 38 0.045 3.2 7.7 1.6 3 23 1654 1675 1653 1675 0.96
25 38 0.00089 0.064 13.1 0.3 3 23 1682 1702 1680 1702 0.98
26 38 2.9e-05 0.0021 17.8 0.9 3 23 1714 1735 1712 1735 0.95
27 38 4.1e-05 0.003 17.3 4.4 2 23 1742 1763 1742 1763 0.98
28 38 2.5e-06 0.00018 21.2 0.5 1 23 1769 1791 1769 1791 0.98
29 38 1.9 1.4e+02 2.7 4.6 1 23 1846 1869 1846 1869 0.96
30 38 1.3e-05 0.00091 18.9 0.3 1 23 1875 1897 1875 1897 0.97
31 38 0.0027 0.19 11.6 5.2 1 23 1903 1925 1903 1925 0.98
32 38 0.0012 0.088 12.7 0.2 1 23 1931 1953 1931 1953 0.95
33 38 8.8e-05 0.0063 16.3 3.3 1 23 1958 1981 1958 1981 0.97
34 38 0.00016 0.011 15.5 1.3 1 23 1993 2016 1993 2016 0.97
35 38 0.0033 0.24 11.3 0.2 1 23 2024 2046 2024 2046 0.96
36 38 6.3e-07 4.5e-05 23.0 1.3 2 23 2053 2074 2052 2074 0.97
37 38 3.7e-06 0.00026 20.6 0.1 1 23 2080 2102 2080 2102 0.98
38 38 4.9e-05 0.0035 17.1 0.6 3 23 2110 2130 2108 2130 0.98

Sequence Information

Coding Sequence
atGTCCTCTTTTGATTATTTGGATTTGTGCCGACTGTGTCTTGTGAAGGATCAAGTATCCGTCCCGATATTTGAAGGAGACGGCGATGCCAGACAAATATTCCACAAGATATCCTTCTGTCTGCCGGTCAAGGTGGACAGAGAAGACAAattgccaaaaaaaatatgcgaCGACTGTGCTTACAAAGTAGAACTCTGTTATCAGTTCTACAATACCACAGCCAATGCCGAAAAGCAACTGCTGCAATGGCTTGGAGAGGTTGGACTTGAAGACAAGCAGGATTATGAGCAAGAAGTCATGAACTcgGATATGATGAAGCAGGAACCGGACAACAGAATAAATGTGACAGTTTTGTCATCGGAAGAACAATCAAACAACATGGAGATAAATATGATTGATGGGATGAGCCTGAGCTTGCCGATCATCATGACAAATCAACAGATGCCCGCGGTGTCGATGAGCTCGACGGATAACTTGCAAAATATCCAGTCGGTAGCTGGTACCAGTGTCCAGACGACCCGGCGCATGCAAAAAGACGGCGGGCATGAGGAGATTGAAGACACTGAAGAGGACGACAACTCCGAGGACGAGTGTGATGTTGACGAGGGAATGCAAGTCGTGAAAGAGGAGAGCGAAAATTCGACGAGCGGCAGCAGGTCAATGGAGCCGACGACTTTTGTTAACGTCGCGTTATCATGCAACGAAGCCGGACCCTCGGGTCTACAGCAGCAAAAACTCGGTGAAATTTCAGAGATGGGTATCCAGCAATCGTCTGAAGGCGATACGAAAACTGGaGGGAAACAGAGGAAAGATTTGCTGATACTGGAACCTTCGAAGATGATCACAAGGTCacagactaaaaaaattagcccTCGGGTGACGGAAGTCAGAACAATAAATAGGTACTTTTGCGACAAGTGCAACATAAATTTCCCACTGGAGAGTATGTTGAATCGGCACAAAGTCTTTCACAATATCAGTCAGCGGTTGAACAAAATGGTGCTGAGGAAAATGGTCCCCAAGAAATTACTGAGTCAGAGAAGGGAATTCAATTGTCGGCTCTGTCAGTTTACGTGCGACAAACAGGAGGAGTTGATAGCGCACAGGGAACGGGAGCACAGCACCAAAGTGGACGAGGACGAGGACGAGATAAATGAGGATCTTGATATCAGCGggggtgaatttaaaatagtcaCTCAAGAAGAATTGTTGGCCGAGCTTAAAGGTTTTGAGAATCCGCAAATACCCTCGGCTGCTGATGTCATTGCTTTTGAGTCTCTACAAGAGGAAGCGCTTCAAGACGGACAAGGACAAGAGTTTATTGATGAGCAAGCTTTGGCTTTAGATGAAAATTCAAGCGGAAGCGAAGATGAAACTATTGATGAAGAAGCCTTGGATGAGGAATTGCTGCAGGAAAAAGAATTTCAAGAATCACTTGGTCAGCTGCAATGCAATTCCTGTGAATTTCGATGCGCTAATAAGAACACAATGTACTCTCACAAACGTCGCCACAGGAtattagaaaatgaaaatcttATTTTGTCTTGCGACGAGTGCGGCTACAAGGCCATTAAAAAATCATCGCTGCACAATCACATCTTCAAGAAACACACCATGAAGTCAAACGCACCGGAAGTGTATAATTGCAGTCTCTGcgagtacaaaaataaaaacaagtatGAGCTTAAAATTCATATAGCGCGAAAACACACTCAGGATTACAAGTTTACGTGCGAGTTCTGTGGaaagaaatttaaagtaaaaggCGACCTGACGAATCACGTGCGCTTTAGTCACAAGGAGCAGCCGGTAATTTGCGACGTCTGCGGCAAGACCTGTCTGAACAGCAACTCGCTGTACGTTCATCAGAAATTCGCCCACTACAAAGCGCAATTCGAGTGTCATATTTGCAAACGGCGAATGGTTACCCAGGAAAATCTTAACGAGCACATGATAAGACAGCATGAGAAGCGCGAGAAAGCCGTTTGCGACGAGTGTGGAAAGAGTTTCTCGCGCAACAGTCGGCTTAAAATTCACATGAGGATTCATACGGGCGACAGACCGTATGTTTGTCAGATTTGCAGTAAAACTTTTATCAGGCGAACGGCTTTGAAGCAGCATCTATTGATCCACACTGGCATCAAGCCTTACGTCTGCGATATCTGTGGAAAAGCCTTCACTCAGAAGCCCGGATTAATCAGTCATCGTAAATCACATCCTGGAAATCATCCTCCGCTGCCTCGAGTTCTCATTGATCATATTCTTGGCAATATTATGActaCCAATCACTGCCAATACGTCAATAAAACTGCTACTGCTACGACAAGAGCGAGGAATGAAGACGATTCTGGGGATCCACGGGGGTTTTTCATCTTTGAAAAAGAGTCGGTGGTGATGAGAAAGTGGCAAATATTGGAATTCGATGGGAAACCTTATTATGCATTTGTACCTGAAAACGAGGAGCCGATAAGTATGGAGAACATCCCGAGTAACGATGATGAGGCTGTCGATGACGATAATGATGGGAATAATAGTGACGAGATTGATTACATTATTCACCAGCAAGAGCAGGATCAGCTGGAGCAGGAGCGAAGGaatcaaatttcaaagttGGCGGGCCAGTGCAAGACTGAAGGTCCGAGCGAGGAAGATGAGCACGAGTTGGTGTCTGTGGGAAACGATGCCAGCTTTTATGATTATCAGTATGATGTCGAtgcaaatattataaataattcagatGAAATTGATGAGACTGAAATGAagccaattttaataaacgatATCTGTCGGACTGATAACGGCAAGGAGCCGACCCGAGGCGATTTGTATCAATTTAAAGTTGAGGGGAGCGTTGTAACGATTGAAAAACTTGCTGAGAACGTGATTTCCATAAAGAATGACGATCATGATAACTACAATGATAATGACAATGACAACGacaatgaaaatgataatgataatgacgaAAGTTGTGACGTAGATGAACATCATGAGGAGATTCAAGTTGAAGAGGAAGTTGTTGAACCGGAAGAAATTGAAATGGACCAGGAGCACATTTCGCAAAgtgaatttattgaagccGAGGAAGTGGGCGGAGAAGAGAGAATCGAGGACGAGGAAGAGATCGATGGAGAAGAAGAGGTAGAGGGAGATGGAGATGGTGATAGAGATGAAGATGGAGTTGGAGATGTTATGGGCCAAGTtgaagaagaggaagaggaTGAGGAAGAACAAGTCCAAGAAGTGCCGCAATATATTGATGCGGACAGTATAGATTCGCAAGTAATCGAGTACGCCAGTGAGAACGAAGAAGACGTAGACGATGTTGAGCCCGTTAGAGAGAAAACTTCCGAAGCGCCTGAGGGTCCGGTGCCCGTGGCGATCTCCACCAAGAGCCAAAGACAACCAAAGTATCGATCAATTCTCCCCAAAGGTACGCCAGCACTAAAGTGCAAAGCTTGCGCCGAGACCTTTACTTCAGCGATAGCCTTCCGGAAACACGTCGCCTGGACTCACAAAAAGAAAGTATGCATTCAAGAGGACGGCGCTTACATTTGCGCGGTCTGCGACTACCGGACACTCAAAAAGAGTCTCTTTGCTGCCCATTTAGAACGGAAGCACGAGACCTGGCCGAAAAAAGGCCCCAGCAATTTGGAGTTTCCCTGTGTCGTGTGTGGGTTCAAGTGTCGCTCCAAGCACTCGCTCCAGTCTCACTTTATCCGCAAGCACACCGACACCTACGAGCACCAATGCAAGTTCTGCCCGAAGCAGTTCAAAGTAAAAGGGGATCTAACGAACCACGTGCGTTTCCACCACAAAGAGAAGCCGATAAACTGCGACGTCTGCGGTAAGCTCTGTCAGAACACCGGGTCCCTCTACGTTCACCAAAAGTGGGCTCACTACAAGCCAAAATATGAGTGTACTATTTGCAAGCGCAGGATGGTAACGCAAGAAAATTTAGACCAGCACATGGTGACGCAACACGAAAAACGTGAGAAAATAGTGTGCGCAGAATGCGGTAAAACGTTCACTAAAAAAGATTCATTTAAACGACACATGGCTGTACATACGGGTAGCAAACCGCACAACTGTCCTATTTGCAACAAAGCCTTTGCTCGGCAGTCTCAATTACGCCAGCATGTACTTATCCATACGGGCAAACGTCCCTTTAAGTGTGATATATGCGGCAAGGCGTTCACACAAAAGCCCGGGCTTATTTGTCACCGCAAGACTCACCCCGGATCCCATCCTCCGCTTCCCGTCATGCCTATCGCCGACCTCGTTAAAGAATTCACCGCCGAGTATCTGATGGAAAACGGGAACGCGAATGACATCAACGACGAGGTTGAGGCTATCAGCGATTGATTAtcttattttAGTCTCCAAGTAACTGGAGCATGCGTTAAAGTTGTGGATACTAGCAGAGTTGAGGTACTGAGCTCAACGAGAGTTAAAATACTCCAGCAGCCGAAGGATCAGACGGAGAATTCAAACGGACGTGAGTTAAAGATTCCCCCGGTGGTTAACAAAAATTCGGTTACAGCGAAGGAGCCAATACTGAAGTACTATTGCAAGAGTTGCGGAGTTGTTTACTCAGGGCGAGCAAGTGACCCGCAGACGGAAGTGTTCAAGCGAATGCATTCGAAGAAACACTTCACCAAGTGCCTGCAATGTTCAGAGACATTTGCGTTGGCAAAAGATTACCTGAAGCATGTGGACGAGGCCCACGAGCTCAAGTACTACAAGTGCGAGCACTGCTGGTACCGGACGACGAGTGTCCGGCAGTATGAGAGCCACAAGAGAACTAGACACAGGCAAGTTTTGATGCAGGTGAAGAAGTTCTCCTGCGGGAGGTGTTTGGAAAAGGACATGACCCATTCCCAGTACCAGATCCACCTGTGCGCGGAAGACGACATTGCAAGAAAACGAGAGAAAGACAAGGAGGGAGAGATTCTGCTGTGCGAGTTCTGCGGCTACACGTCGCGGAAGAAAAAGTCGATGAAGTTGCACATAAACCAGTACCACGCTGAGCGTAAGTTTGGGTGCAATATCTGCGAGAAGAAGTTCATCAGCGATCAGGGGCTGGTAAAGCACATGAACTACCACAAGAATCCGGTGACCAAAGTCCGCAAACTCTTCTGCGACCACTGCGGCAAAGGTTTCAAGGACAAACCGGCTCTGAGGATGCACATCATGAACACCCACATGGGCATGAAGCTGGCCAAATGTTCAATTTGCCACAAGTCCTTCGCCAAGAAGACGACGTTGAGGCAGCATTTGCTCACCCACAGCGGCAAGCGCCCGTACACTTGTGATATCTGCGGAAAAACTTTTGTCCAGAAACCCGCGCTCAGTAGCCACCGGAAACAACACCCTGGAAAGCTTCCACCTATGCCTGTAGTTTATATTGATTCCTACATACGCGAGCTTGATCCCTCGATGGTCACTTCCTCGATTGTCCCGGTTCCGAAGCTCAGGACAGAatgTCAAGGGTTTCAGCGGATAAATCCTAAAGggaaaaaatctaaagatcCACACAAGTGTGTCAAGTGCGACGCGTATTTTTTCCACATGACTAAGCTAGTCGAGCATCTGAAGAATACTCACGGCATTGAGAACGCTTTCAACTGCGACGAGTGCGGGAAATCCTTCAAAAGTCCCATGAATATCGCGCGGCACAAATTGATCCACTCGGGgcttaaaaaattctcttgcGACGTCTGCGAGTACTCGTGCCACCAGAAGGCCAATTTAGAAACGCACAAACGGAGACACGCGCAAGATTATGCGTTCAAGTGCGGCGTTTGCAAAAAAGGTTTTGTCTCTAAAGCGGATTTTCTTGAGCACGAAATTTTGCACACGAACGTAAAGTTTCGATGCGAGatctgcaataaaaattattcttacaaACGAAATCTGGATGCGCACTTGAGGCTCTGTCACTACGAGCTGAGGAAAATGAATAAGACGAGTCAGTATAATTGTACCGAGTGCAAAGTGGCCTTCGCGACCCTCAGAACGCTGAAGAATCACCAGCGAAATCGTCACCGCGTTAAGAAGCGGCAAGAATATCTCTGCGACCTCTGCGGCGCAAAAGTATCCTCGAAAAAAGCTCTCGATATTCACACGCGGACGCACACCGGTGAGAGAAACGTCAGTTGCGATTTATGCCCGAAAAAATTCACCACCAAAGAGAACCTTAAAATTCACAGACGAACTCACACGGGAGAGAAACCGTATGTGTGCAACGAATGCGGTAAAGAATTTGCTCAGAGGTCTCCGCTGGTAATTCATTTGCGTTATCACAACGGCGAGACTCCCTACTGGTGTCCAGAATGTGGCAGAGGTTTTGTCACCAATAATTTTCTACAGAAACATCGAAAAAATCACGATATCTCGAAAATTGTCGTCCCGCGCTTCAAATACGAGCAACCGCTTCATTcttaa
Protein Sequence
MSSFDYLDLCRLCLVKDQVSVPIFEGDGDARQIFHKISFCLPVKVDREDKLPKKICDDCAYKVELCYQFYNTTANAEKQLLQWLGEVGLEDKQDYEQEVMNSDMMKQEPDNRINVTVLSSEEQSNNMEINMIDGMSLSLPIIMTNQQMPAVSMSSTDNLQNIQSVAGTSVQTTRRMQKDGGHEEIEDTEEDDNSEDECDVDEGMQVVKEESENSTSGSRSMEPTTFVNVALSCNEAGPSGLQQQKLGEISEMGIQQSSEGDTKTGGKQRKDLLILEPSKMITRSQTKKISPRVTEVRTINRYFCDKCNINFPLESMLNRHKVFHNISQRLNKMVLRKMVPKKLLSQRREFNCRLCQFTCDKQEELIAHREREHSTKVDEDEDEINEDLDISGGEFKIVTQEELLAELKGFENPQIPSAADVIAFESLQEEALQDGQGQEFIDEQALALDENSSGSEDETIDEEALDEELLQEKEFQESLGQLQCNSCEFRCANKNTMYSHKRRHRILENENLILSCDECGYKAIKKSSLHNHIFKKHTMKSNAPEVYNCSLCEYKNKNKYELKIHIARKHTQDYKFTCEFCGKKFKVKGDLTNHVRFSHKEQPVICDVCGKTCLNSNSLYVHQKFAHYKAQFECHICKRRMVTQENLNEHMIRQHEKREKAVCDECGKSFSRNSRLKIHMRIHTGDRPYVCQICSKTFIRRTALKQHLLIHTGIKPYVCDICGKAFTQKPGLISHRKSHPGNHPPLPRVLIDHILGNIMTTNHCQYVNKTATATTRARNEDDSGDPRGFFIFEKESVVMRKWQILEFDGKPYYAFVPENEEPISMENIPSNDDEAVDDDNDGNNSDEIDYIIHQQEQDQLEQERRNQISKLAGQCKTEGPSEEDEHELVSVGNDASFYDYQYDVDANIINNSDEIDETEMKPILINDICRTDNGKEPTRGDLYQFKVEGSVVTIEKLAENVISIKNDDHDNYNDNDNDNDNENDNDNDESCDVDEHHEEIQVEEEVVEPEEIEMDQEHISQSEFIEAEEVGGEERIEDEEEIDGEEEVEGDGDGDRDEDGVGDVMGQVEEEEEDEEEQVQEVPQYIDADSIDSQVIEYASENEEDVDDVEPVREKTSEAPEGPVPVAISTKSQRQPKYRSILPKGTPALKCKACAETFTSAIAFRKHVAWTHKKKVCIQEDGAYICAVCDYRTLKKSLFAAHLERKHETWPKKGPSNLEFPCVVCGFKCRSKHSLQSHFIRKHTDTYEHQCKFCPKQFKVKGDLTNHVRFHHKEKPINCDVCGKLCQNTGSLYVHQKWAHYKPKYECTICKRRMVTQENLDQHMVTQHEKREKIVCAECGKTFTKKDSFKRHMAVHTGSKPHNCPICNKAFARQSQLRQHVLIHTGKRPFKCDICGKAFTQKPGLICHRKTHPGSHPPLPVMPIADLVKEFTAEYLMENGNANDINDEVEAISD*LSYFSLQVTGACVKVVDTSRVEVLSSTRVKILQQPKDQTENSNGRELKIPPVVNKNSVTAKEPILKYYCKSCGVVYSGRASDPQTEVFKRMHSKKHFTKCLQCSETFALAKDYLKHVDEAHELKYYKCEHCWYRTTSVRQYESHKRTRHRQVLMQVKKFSCGRCLEKDMTHSQYQIHLCAEDDIARKREKDKEGEILLCEFCGYTSRKKKSMKLHINQYHAERKFGCNICEKKFISDQGLVKHMNYHKNPVTKVRKLFCDHCGKGFKDKPALRMHIMNTHMGMKLAKCSICHKSFAKKTTLRQHLLTHSGKRPYTCDICGKTFVQKPALSSHRKQHPGKLPPMPVVYIDSYIRELDPSMVTSSIVPVPKLRTECQGFQRINPKGKKSKDPHKCVKCDAYFFHMTKLVEHLKNTHGIENAFNCDECGKSFKSPMNIARHKLIHSGLKKFSCDVCEYSCHQKANLETHKRRHAQDYAFKCGVCKKGFVSKADFLEHEILHTNVKFRCEICNKNYSYKRNLDAHLRLCHYELRKMNKTSQYNCTECKVAFATLRTLKNHQRNRHRVKKRQEYLCDLCGAKVSSKKALDIHTRTHTGERNVSCDLCPKKFTTKENLKIHRRTHTGEKPYVCNECGKEFAQRSPLVIHLRYHNGETPYWCPECGRGFVTNNFLQKHRKNHDISKIVVPRFKYEQPLHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-