Basic Information

Gene Symbol
-
Assembly
GCA_030347285.1
Location
JAQQBR010001835.1:622316-625228[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 6.9e-05 0.005 16.9 2.1 1 23 363 386 363 386 0.94
2 11 0.00051 0.037 14.2 0.5 1 23 395 418 395 418 0.96
3 11 0.0052 0.37 11.0 4.1 1 23 462 484 462 484 0.97
4 11 1.1e-06 8.2e-05 22.5 1.5 2 23 526 547 525 547 0.97
5 11 0.00019 0.014 15.6 2.0 1 23 552 575 552 575 0.95
6 11 1.9e-06 0.00014 21.8 1.0 1 23 612 634 612 634 0.98
7 11 7.8e-07 5.6e-05 23.0 0.9 1 23 644 666 644 666 0.96
8 11 8.4e-07 6.1e-05 22.9 1.2 1 23 672 694 672 694 0.99
9 11 1.1e-05 0.0008 19.4 0.2 1 23 700 722 700 722 0.98
10 11 0.0019 0.14 12.4 4.2 1 23 728 750 728 750 0.98
11 11 0.00041 0.03 14.5 0.3 1 21 756 776 756 777 0.94

Sequence Information

Coding Sequence
ATGGAAGTCAcaagtgaaaatgaaataattggaaaatttattgatacattTGAGTTACATGGTAATGAATGTCGTTTGTGTTTGAAAAAAGCAAACCAAATATGGGAACtatttgaaaatgatgatgaattaccaaaaaaaataatggcttGCGCTCATGTTCAGattaatcAAGGTGACGGACTTCCAACAATAATATGTTTAACATGCCGACAAATATTGGACGTGTcgtacaattttaaatttcaagtcGAAAAATCAGATGAAAAGTTACGACAAATGTATCATTTAAAAACATCATCACTTATGGAATATGAGCAGAAAGAAATTGGAGTAAATGATTCAGTAATACAATCAGTAAATCAAGCAATAACTGAAACAATAAATGATgtgaagaaaatgaatgaaaatgaatcaaTAACAGATAACCTCAAAAGTGGCGTTGAGTTGACAAAATTTGCAACTTCGGAGGAAACTATTGACAACAGAGAAAACCAAAATTGTAtcagtataataaatagattggacaatcataattttgatgataatcATCAAGAAAAAGCTTCGTTCAATGTTGACCTCAATCATGAtgattatatcaaaaataaacattgttaccataatattaataatgtgatagaagaagaaaaaaatatgaatgaaaagataattgatatttcacATGTTGCGGGACCGAAAAGTGATTTAATCGAGAAACTGGATCATTTTGAtactataaaagaaaaaaattgtattttagctgatgaagaaaatgagctatctaatgatgatgaaaatgaaaatgatgacgATCAAGTTTAtcacaataatgaaatatttcttgaGCAAGAGGGAAAAGTAGATTTCATTGAAAGAATTaatgaagagaatgaaaaaaagcaTAACGATAAAGATAATACCAATAtcgataatgataataatgatgatgaagatgatgaagatgatgaagataatgaaaatgatgatgatgaagatgatgataatgatgacaatgaaaatgatgatgatgataatgtagATGACGATGATGGTAAAAaggatgatgataaattgctGACATCAAGGCATAAATGTTTACATTGTGTAAAAGTATTTGCATCAACATCAGAATTGCGTCGACATATAGTAATAACtcacaataacaataaaacaaaattacgtTATGTTTGTTATATGTGCGATAAACAATTCGCTAccgtaattaaattaaaaaaccatGTTTTGCGCAGTCATGATAgtttaaaaaatgatgatataaataaagatgaagtaaataaaagtgaatataatGAGGAATtaggtgaaaaaataaatgagaaaaatttaatgaccGATGAAACAATCGAtagaaaaaattcgaaattttcaTGTAAACATTGTCCGAAACAATTTACGTATGAAAAACCATTTTTGACACATGCAAAACGTCATCCAGAATACatgaatcaacaaaaaaataaatcaatgaaaacgGATGCAGAATTAATGTCACGTAATATTGAACGTGAACGTTTATACGAATCTGAAGATGATGATATGCCGTTAGAAGGATTACAATGTACACAGTGtggtaaattatttgcaaCCAAACGAAATTTAACGAGACATTTATCTACACATACTGGTTTAAAGTTCAATTGTAAAACATGTACAAAAGAATTTTCACGTTTAGATAAACTCAAAGAACatgaacaaattaaacataaaaatgaattcttCGGACAATCGGATGATTATGATGACGACGATTCagataatgaaatgaaagccAACGGTTCGGAAAGTCCAAAAAagGACAAACACAATCGTCCACATAAATGTTCAATGTGTCCAAAGGCATTTGCTCAAGCCCAATCGTTAACTAATCATATGGAACGACATAAGCGTGTAAAAGATACACAAAAGCGTTTTTTGTGTGAAGTATGCAGCAAATGTTTTGCGCAAAGTGGCTCTTTAGTTGCGCATATGCGAACTCATACAGGCGTTAAAccatatgtatgtaatgtttGCAATCGGGCATTTACAAAATCAACATATTTACAGTTACATTTGCGAACACATAGTGGTGAAAAACCGTATATTTGTCAGTATTGCAGTCGAGCGTTTGCGCGTGCGAATACATTGGCACGACATATAACTATGCACACAGGCGAAGCAAAATATCATTGtcaaatatgtatgaaatcATTCAGACGTTTAACATCACTTAATGAACATACTTACACGCACACTGGTCAACGACCTTACGCATGTAAAATTTGTACTAAACGATATAATAATGCAGGCTCATTATATGCACATACGAAAAAATGTAAAGCCCAACAATTGAACACCAGCACAAGTAGTACACCATATCACAATATTACCGTACATGAAGatgttaataatcaaaatgttGATAATACAACGTCTGCTATGTTGATTTATTCTCAAAGGAAAATTCCGGATGACGTGACAAACGTTACTAATGCTGTTAGTGGTCAATCAATAACAGCATCATCACCGTCATTTTCGATTGCAAATAATGTTCATAATCAAAAATCATCATTaccaacaaatattattcagcAATATACAATCGAACATTCAAATGTCTACACACTCGACGCgaaacaatacaaaaatcCGTACTACACTATTTATCCAgggatataa
Protein Sequence
MEVTSENEIIGKFIDTFELHGNECRLCLKKANQIWELFENDDELPKKIMACAHVQINQGDGLPTIICLTCRQILDVSYNFKFQVEKSDEKLRQMYHLKTSSLMEYEQKEIGVNDSVIQSVNQAITETINDVKKMNENESITDNLKSGVELTKFATSEETIDNRENQNCISIINRLDNHNFDDNHQEKASFNVDLNHDDYIKNKHCYHNINNVIEEEKNMNEKIIDISHVAGPKSDLIEKLDHFDTIKEKNCILADEENELSNDDENENDDDQVYHNNEIFLEQEGKVDFIERINEENEKKHNDKDNTNIDNDNNDDEDDEDDEDNENDDDEDDDNDDNENDDDDNVDDDDGKKDDDKLLTSRHKCLHCVKVFASTSELRRHIVITHNNNKTKLRYVCYMCDKQFATVIKLKNHVLRSHDSLKNDDINKDEVNKSEYNEELGEKINEKNLMTDETIDRKNSKFSCKHCPKQFTYEKPFLTHAKRHPEYMNQQKNKSMKTDAELMSRNIERERLYESEDDDMPLEGLQCTQCGKLFATKRNLTRHLSTHTGLKFNCKTCTKEFSRLDKLKEHEQIKHKNEFFGQSDDYDDDDSDNEMKANGSESPKKDKHNRPHKCSMCPKAFAQAQSLTNHMERHKRVKDTQKRFLCEVCSKCFAQSGSLVAHMRTHTGVKPYVCNVCNRAFTKSTYLQLHLRTHSGEKPYICQYCSRAFARANTLARHITMHTGEAKYHCQICMKSFRRLTSLNEHTYTHTGQRPYACKICTKRYNNAGSLYAHTKKCKAQQLNTSTSSTPYHNITVHEDVNNQNVDNTTSAMLIYSQRKIPDDVTNVTNAVSGQSITASSPSFSIANNVHNQKSSLPTNIIQQYTIEHSNVYTLDAKQYKNPYYTIYPGI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01001582; iTF_01000759;
90% Identity
-
80% Identity
-