Basic Information

Gene Symbol
topi
Assembly
GCA_949715475.1
Location
OX454421.1:59312450-59331233[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 5.6e-05 0.0057 18.2 3.0 1 23 190 212 190 212 0.97
2 10 1.3 1.3e+02 4.5 0.3 2 23 233 255 232 255 0.89
3 10 0.00055 0.056 15.1 0.5 2 23 317 338 316 338 0.95
4 10 0.052 5.3 8.9 2.1 2 21 385 404 384 408 0.89
5 10 0.0041 0.42 12.3 0.6 3 23 424 445 424 445 0.92
6 10 1.1e-06 0.00011 23.6 1.9 1 23 460 482 460 482 0.95
7 10 0.0013 0.13 13.9 1.0 1 23 488 513 488 513 0.96
8 10 0.53 53 5.7 1.7 1 23 519 541 519 541 0.88
9 10 6.4e-07 6.4e-05 24.3 0.3 3 23 549 569 547 569 0.98
10 10 0.0021 0.21 13.2 1.9 1 23 575 598 575 598 0.95

Sequence Information

Coding Sequence
ATGGACTCGCAACTAATTCCAAATACATTTGTCCACGAACCACTCACCGATTCTGCACAAGTTGAGTTGACTGAGAAGTGCGACGAAAACGGAATAGGACAGATTTCGAATCATAATTATCAAATGAGTGAACTAGTAGTTAACACCGTGAATGAAGAAAGCAATGATTCTCAATGTGTGAATAACTCCGAACAAACTGAATACGTTGTGGAGCTAAAATATGATGGTGAGAATACACAATTTGAATTGGTTCCAGCAAATGTGCTAGTCATGGATGAACTCGTCAAAAGAGATGACCAAAAATTGGCAGCTCCCAACTCTGCATTTATCATACATTGCCTGAATTGTGATAATCTATTTGAAGAGGCAGATTTCTTTATGCATATATGTGACTTTGACGAAAATAAAGTGCTCGTGAAAGACGAACAAGAGGTTGTTATTAAAACTGAAATTCCTGAGGAGCTTCTGTGCATAAGGCAATTACGTGAAAATAACGCGTTCATACGAAAGTGGCTAAAAGAAGAACTGAAAATGGATTTATCACGTTCGAGTAAAAAAGATGGACCTCATGAGTGTACAATATGTGAAAGAAAATTTGTTCATGAATCAGGTTTATCCAGGCATATGGACAAGCACGCTTTAGATTTAATTCCTACAGCGACCAATCCAAACAATAGTACCTTGAAAGTTTTAACCAAGTGTTTAATATGCGGACGTATATTGTTCTCCGCCGAAGAAGCGTTTAAACATGTTCACGAAGATCATGAAGTGTTTCAGAGTGAAGCGGAAGACGAAAATAAATCAATTGAAGATGAAGGAATAGAAGACATAACTTCTGATAATAGGGAGAGCATCACTGAGTATGCAGCTGAACTCTTGGAGtCATATAAAAAAGACGACCGAAATGTAATTCCTCATATTAAAGTTGTGATACTGAGCACTCTCCTGCAATGCGAATTCTGTGATCATTCATTTTCACAAGTATCAGACCTTTTGATACACGAAGCGTCACATGATCCACTAGCCGGCTTTTCCTGTGTATCCTGTGGAATAAGTGTTCAGACAATAAAGGATATAGTTCTTCACTGGCAAACGGAATGCGCATATGTCAAGGACCAAAACCGAAGAAATATCCTACTGCATAAGCATCTTGTTTGTAATGTTTGCGAGAATAAGTTTAACTCACACGATCATCTATTAGAACACCGCTATTCATCGCTCCATTTATTTCCTCGTCTCAGTAAGGATACAAGAAAAATGTTGATTGGATGTGAATATTGTGGAGTATTTTTCGAAAATGCTGAATCCTTACTAAAACATCATGATGAAAACCAtgccaaaaagacaaaaaaggaACCGACAACTAGATATCGACAATATTTGTGCGATGTATGCGGAAAATCATACACGCAATCTAGCCATCTTTGGCAGCATTTAAGATTTCACAGAGGCGTCAAACCGTTTGCATGCAAGGAGGCCGGATGCAATAGACGATTTACGATTCGTCCCGATCTCAATGATCATATACGAAAATGTCACACTGGAGAGCGACCATATCATTGCCTTGTATGCGGAAAACGGTTTTTGACCGGTTCGGTATTTTATCAACATCGACTTATTCATCGCGGCGAAAGACGTTATGGGTGCGATGAGTGTGGCAAACGTTTCTATCGTGCCGATGCACTGAAAAATCATCAACGAATTCATACGGGGGAGAAGCCATACAATTGTATGTATTGCAATAAAAACTTTAGACAACGGGGAGATCGTGATAAACATATCAAAGCGCGTCATGCCAATTGGGATGCAAACGCCCGAAGACTGCTGTCAAATCCAAAAGTGAGAACCCAAAATGTCGGTGATGTTGTCTATGTGGGCAACGTGCCATTCCCTACTAGTATGTTTAAACCGATTTTACGTGATATTGACGAAAATGTAAATTGA
Protein Sequence
MDSQLIPNTFVHEPLTDSAQVELTEKCDENGIGQISNHNYQMSELVVNTVNEESNDSQCVNNSEQTEYVVELKYDGENTQFELVPANVLVMDELVKRDDQKLAAPNSAFIIHCLNCDNLFEEADFFMHICDFDENKVLVKDEQEVVIKTEIPEELLCIRQLRENNAFIRKWLKEELKMDLSRSSKKDGPHECTICERKFVHESGLSRHMDKHALDLIPTATNPNNSTLKVLTKCLICGRILFSAEEAFKHVHEDHEVFQSEAEDENKSIEDEGIEDITSDNRESITEYAAELLESYKKDDRNVIPHIKVVILSTLLQCEFCDHSFSQVSDLLIHEASHDPLAGFSCVSCGISVQTIKDIVLHWQTECAYVKDQNRRNILLHKHLVCNVCENKFNSHDHLLEHRYSSLHLFPRLSKDTRKMLIGCEYCGVFFENAESLLKHHDENHAKKTKKEPTTRYRQYLCDVCGKSYTQSSHLWQHLRFHRGVKPFACKEAGCNRRFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHQRIHTGEKPYNCMYCNKNFRQRGDRDKHIKARHANWDANARRLLSNPKVRTQNVGDVVYVGNVPFPTSMFKPILRDIDENVN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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