Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_949715475.1
Location
OX454417.1:96702324-96704163[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00031 0.032 15.8 4.0 2 23 122 144 121 144 0.94
2 12 0.00077 0.078 14.6 0.4 1 23 174 196 174 196 0.97
3 12 8.7e-05 0.0088 17.6 4.9 1 23 244 266 244 266 0.96
4 12 0.00017 0.017 16.7 0.3 1 23 272 295 272 295 0.96
5 12 2.1e-07 2.1e-05 25.8 2.3 1 23 301 323 301 323 0.98
6 12 0.00092 0.093 14.4 1.2 1 23 329 353 329 353 0.95
7 12 1.5 1.5e+02 4.3 4.7 1 23 359 382 359 382 0.97
8 12 3.1 3.1e+02 3.3 4.4 1 23 414 436 414 437 0.70
9 12 0.00061 0.061 14.9 0.7 2 23 443 464 442 464 0.97
10 12 0.58 58 5.6 2.4 1 23 470 493 470 493 0.92
11 12 7.6e-06 0.00077 20.9 0.7 1 23 499 521 499 521 0.98
12 12 0.00042 0.042 15.4 1.0 1 23 527 550 527 550 0.98

Sequence Information

Coding Sequence
ATGCTGCCCCAAAAAATTTGCCACAGTTGCGAAAGAGACCTCAAAGTTGCGTACAATTTCAAAATTCGTTACGAAACGACCGATAAGTGTTTTCGTGACAGACTTATTTGTAAAATTGAGAAAACGCCTGAACGGATACAATTTGAAACCATTGATCACAACGCAACGGATCCAATATTGAATTTCGAGGGCATCACtgttaaagaagaagaaattgacGATTTATTTATAACCGAAAACGAATACAAACACGATGCGGAAATGGCCGTTGTGGAGGAAGTAGACGAGGTATATTTGGACGAGAAATGTTCGATCATGGTAAAATTAGAGGCTGATTCGGGTCATAGTTCTGAGAATCCGGTGACGTGTGAAATATGCAAAAGACACTTTACGGATAAATATACTTTAGAAAATCATGTAAAAGAATGTCATAAAGTGACAAACATATCCGATGCAAGTAAATCTGATGACGAAGCAAGCTTGATCCCCCATCTGGATACGCACAACACACAATCGATTTACGACTGTGATCAATGCCCTTCGACGTTCAAAACCGCCAATGAACTTATTCTGCATAAAACCACGCATAAAACCGAAGAATTGCAAGAACAAAGTAACAACACCTCGAACATAACGGGAAAGCCTTATGAATGCAAATTTTGTGGCCTGGAAAATGAAGAGTATGCAAAGCACATACAACACGTTCGCACTCATACCGGTAAAAAACGATTTACATGTGATGTATGCAACAAAGACTTCACTAGAAAAGATCATCTCGCAACACATAAGCATCTTCACACGAAAAACAAGCCTTATCCTTGCGATTTGTGCGAGAGGGCTTACAgtcaaaaaatacatttaagaGACCACGTACTATCAGCCCATACAAAAATAAAACCATATGCATGCAAACATTGTGGGGTGGCATTCacaacaaatttcaatttgaaaattcataTGCGTAAACATACCGGCGAAAAACCGTATAAATGTAAGCTTTGCGCGGAGCGGGTGGCATTCacaacaaatttcaatttgaaaattcataTGCGTAAACATACCGGCGAAAAACCGTATAAATGTAAGCTTTGCGCGGAGCGTTTCATTTGTTCAAAATATAGGAACGCACATATGAAAAGGAAGCATGATGCAAGGGAACGAAGCAAAATACTCGAGTCTGAGGATGATACAGTCGAGAGTCCGAAAGAAGTAGAAAAACGGGGAAAATTGAAACCAGCTTATAAATGCGAATACTGTGGCAAGGAAAACGGAAAATTGTCAAGTCATTTAAATCACCTTCGAATTCATAAAGATGAAGAACCGCTTGTTTGCAATATATGCAATAGCACTTTCATCTCAAAACCAAAATTCGATTATCATATGCGTACTCACACCTACGGTAAGCCTCATGTGTGCAAAGTGTGTTCAAAGGGTTTTCATGCAAAACAAAGTCGAGACAGGCATGTCAGAGCCGTTCATGACAGGATCAAAGCTTTTGTGTGCAAAGAGTGTGGGCAGGCTTTCGCAGCAAGCTGTAATTTGCAAATTCACTTGCGTAGACATACCGGCGAAAAACCGTATAAATGTAACCTATGTGAGGAGCGTTTCATAGGTTCAAGCCAGCGGAACAGACATCTACAGAAAGAGCATGCTGACCGACAAATCAATGTCGTTTCTAAGAATGACAAAGCCCAGGCTGCAATGGAGTGCGATAATAGCGATGATGACGTGGTAGAGGTCATTGTAATGAAAATAGAGGAGGAAGAAGAGCTTCAGTGa
Protein Sequence
MLPQKICHSCERDLKVAYNFKIRYETTDKCFRDRLICKIEKTPERIQFETIDHNATDPILNFEGITVKEEEIDDLFITENEYKHDAEMAVVEEVDEVYLDEKCSIMVKLEADSGHSSENPVTCEICKRHFTDKYTLENHVKECHKVTNISDASKSDDEASLIPHLDTHNTQSIYDCDQCPSTFKTANELILHKTTHKTEELQEQSNNTSNITGKPYECKFCGLENEEYAKHIQHVRTHTGKKRFTCDVCNKDFTRKDHLATHKHLHTKNKPYPCDLCERAYSQKIHLRDHVLSAHTKIKPYACKHCGVAFTTNFNLKIHMRKHTGEKPYKCKLCAERVAFTTNFNLKIHMRKHTGEKPYKCKLCAERFICSKYRNAHMKRKHDARERSKILESEDDTVESPKEVEKRGKLKPAYKCEYCGKENGKLSSHLNHLRIHKDEEPLVCNICNSTFISKPKFDYHMRTHTYGKPHVCKVCSKGFHAKQSRDRHVRAVHDRIKAFVCKECGQAFAASCNLQIHLRRHTGEKPYKCNLCEERFIGSSQRNRHLQKEHADRQINVVSKNDKAQAAMECDNSDDDVVEVIVMKIEEEEELQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
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