Basic Information

Gene Symbol
-
Assembly
GCA_030762175.1
Location
CM060830.1:4971425-4992207[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 1.5e-07 1.8e-05 26.6 0.6 1 23 135 157 135 157 0.98
2 13 4.3e-07 5.3e-05 25.2 1.4 1 23 163 185 163 185 0.98
3 13 8.9e-07 0.00011 24.2 1.1 1 23 191 213 191 213 0.97
4 13 3.5e-05 0.0043 19.2 6.1 1 23 219 241 219 241 0.97
5 13 1.3e-06 0.00016 23.7 1.5 1 23 247 269 247 269 0.97
6 13 6.4e-07 7.8e-05 24.7 2.1 1 23 275 297 275 297 0.97
7 13 8e-05 0.0098 18.1 2.9 1 23 303 325 303 325 0.98
8 13 1.1e-05 0.0013 20.8 3.4 1 23 331 353 331 353 0.97
9 13 1.4e-07 1.7e-05 26.7 0.1 1 23 359 381 359 381 0.98
10 13 1.8e-06 0.00021 23.3 1.0 1 23 387 409 387 409 0.98
11 13 1.5e-06 0.00018 23.5 3.5 1 23 415 437 415 437 0.98
12 13 4.3e-05 0.0052 18.9 1.7 1 23 443 465 443 465 0.97
13 13 1e-07 1.3e-05 27.2 0.1 1 23 471 493 471 493 0.98

Sequence Information

Coding Sequence
atggacTTAAAGCTAGAAATTAAGGAAGAGCCCCTGGACTGTAGCATGACTTTGCTGGAGTTGAAACCAGAAACTGAGGAAGAAAGCTCCTCTTGTACCACTCATGACACTGAAGTAAAATGTGATAGAATGATAAAAGAATGCAGTGATTATGAGATAATGGACCCCAAGTTAGAGTTCAAGAAAGAACTGCTGTACCTCAAAAAAGATCCACTTGAGCTCATATTCAAAACTGAAGAGATTGCAAATAATGATGGTCTGGATACTATGCTGAAAAAAGAGATAAAGGAGCAGAAGGAGTCTGATGTAGCTTTAATGAAGCAGGAGATCACAATTGAGGAGTCAGACTTATCATACAGTGATTCAGGgaaacatcttttgattcatgagggcaagaagccacataagtgtgaagtttgtggaaagagctttatacGTGCATATGATTTGAGacaacatattttgattcatgagggcaagaaaccacataagtgtaaagtttgtggaaagagctttatttATGCATCTTATTTGAGGCagcatattttgattcatgagggcaagaagccacataagtgtgaagtttgtggaaagagctttatccgTGCGTCTGGTTTGAggaaacattttttgattcatgagggcaagaaaccacataagtgtgaagtttgtggaaagagctttatccaTGCATGTAATTTGAAGGCACATCATTTGATTCATGAGGACAAGAAgccccataagtgtgaagtttgtggaaagagctttatccaTGCATCTGATTTGAGGGCACATTTTTTGAtccatgagggcaagaagccccataagtgtgaagtttgtggaaagagttttacccaTGCTAGTGGTTTGAAGGTACATCGTTTGATTCATGAGgacaagaagccacataagtgtgaagtttgtggaaagagctttatcaAAGCATTTTGTTTGAGgctacatcttttgattcatgagggcaagaagccccataagtgtgaagtttgtggaaagagctttacccatgCAAGTGGCTTGAGGGGGCAtcatttgattcatgagggcaagaagctaTATATGTGTGaggtttgtggaaagagctttattcAAGCATCTGCTTTGAgaaaacatcttttaattcatgagggcaaaaagcctcataaatgtgaagtttgtggaaagaactttacCCAAGTACCAAATTTGAGGaagcatcttttaattcatgagggaaaaaagccccataaatgtgaagtttgtggaaagaactttacCCAAATATCACATTTGAggaaacatcttttaattcatgagggcaagaagtcccataagtgtgaagtttgtggaaagagttttacccaTGTAAGTGGTTTGAGTGGACATcgtttgattcatgagggcaagaagccataCATGTGTGAAgattgtggaaagagctttattcAAGCATCTGCTTTGGagaaacatcttttaattcatgagggcagAAATTCCCATAAATATGTAAAGTTTGTGGAACAAACATTATCCTAG
Protein Sequence
MDLKLEIKEEPLDCSMTLLELKPETEEESSSCTTHDTEVKCDRMIKECSDYEIMDPKLEFKKELLYLKKDPLELIFKTEEIANNDGLDTMLKKEIKEQKESDVALMKQEITIEESDLSYSDSGKHLLIHEGKKPHKCEVCGKSFIRAYDLRQHILIHEGKKPHKCKVCGKSFIYASYLRQHILIHEGKKPHKCEVCGKSFIRASGLRKHFLIHEGKKPHKCEVCGKSFIHACNLKAHHLIHEDKKPHKCEVCGKSFIHASDLRAHFLIHEGKKPHKCEVCGKSFTHASGLKVHRLIHEDKKPHKCEVCGKSFIKAFCLRLHLLIHEGKKPHKCEVCGKSFTHASGLRGHHLIHEGKKLYMCEVCGKSFIQASALRKHLLIHEGKKPHKCEVCGKNFTQVPNLRKHLLIHEGKKPHKCEVCGKNFTQISHLRKHLLIHEGKKSHKCEVCGKSFTHVSGLSGHRLIHEGKKPYMCEDCGKSFIQASALEKHLLIHEGRNSHKYVKFVEQTLS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-