Basic Information

Gene Symbol
topi
Assembly
GCA_949987695.1
Location
OX465290.1:74335814-74339285[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00016 0.027 16.5 0.3 3 23 283 304 281 304 0.92
2 11 0.19 31 6.9 0.7 2 23 358 379 357 380 0.94
3 11 5.4e-06 0.0009 21.2 3.2 1 23 385 408 385 408 0.96
4 11 0.48 81 5.6 0.8 2 23 425 445 424 445 0.95
5 11 0.012 2 10.6 3.0 1 23 459 481 459 481 0.93
6 11 9.7e-06 0.0016 20.4 1.5 1 23 490 513 490 513 0.97
7 11 9.5e-05 0.016 17.3 1.6 1 23 518 540 518 540 0.96
8 11 6.5e-06 0.0011 20.9 3.1 2 23 546 567 545 567 0.98
9 11 0.0023 0.38 12.9 2.4 1 23 573 595 573 595 0.97
10 11 0.00074 0.12 14.5 3.1 1 23 600 622 600 622 0.95
11 11 0.031 5.1 9.4 1.5 1 23 627 651 627 651 0.97

Sequence Information

Coding Sequence
ATGGTAATTCAATGTCGCGCTTGCCTTAATACAAACAACACCGCCTTTATACGCATGGAATCGAAGATTGCGGATGGCCTAGATTTTTTCACATGCTTTTGTATGTGCACCCGACTGAATGCAGCACTAAATGATGGATTACCAGGTATACTGTGCACCAATTGCTCTGAAGAGCTTCAAATAGCTTTTAACTTTGTGCAGAATGCACGACAAGCTGACACAATGCTTAGAGAGGTATTGACAACCAAGATCATACGCGGAGATGCGATAGAGACCTTAGACAGCCAAGACGTTTTAATAATAGAAGGCTCAGTAACGGAGGCAGAAGGTGAAGTTGATTCTTATGTACTTGAAGAACTGCTTGAGGATGAGTCCGATGATGTTATTGAGGATGATGGTAACATCTGTACAGTGGAGgtcaaaaaaataaaccgaGAAATTTCGGAAGAATCATTGCACGAATTAGATTTTATGGAAGGTAAACTGGCTATAGAGGAAATAGTTGAAGTGCAGGCAGAACAAATCAACACACGAGACTACTATGCTGAAGATGAGAGTGACGAGGTTTACTTGAGAGAGTACCAAGATAATGATAATGAAGTACACAGCAGCAATTGGAATATCACACCCAAAggcaaaaaatggaaatgtatTGAATGCAAACGTATCTTATGTGGTGATGTTTCCTATGAAGGTCATATGAATATGCATCGCTCATTGCGACCATACAAATGTGGTATGTGCGCATGTGCATTTCGTTGTAAAGTTATGCTTGAGAGACACACTCAATTTCGTCACCATCAAACACCTCCGGACAAAATGGAAGAAATGtctcCGTCTACCATCTGTGAAAtatgcacaaaaatatttacaacacCCACAGAATTACAAGAGCATCATGAATTAGTTCATTCTGACAGTTCTACAACCCAATGTAAAAAGTGTACGCGGATAGCACCATTTGCACGCACTGAAATCATTGAACATTTCCGTACAGAACATCCCGAAGACTATCAAAAACATTTTCCTACAGTAGAAATGCCCCTTAAACCAGTCACTCCGACATCATGGCAATGCGATGTTTGTAAGAGTTATCTAAGTTCAGAGGTAACTTTACAAGATCATCGAAATATACATCACAATGATCGTCCGCATGAATGTCAGTTTTGTAAAAAACGTTTTGCTACTACTAGTAACTTACGTCAACATATGCGTGGTGTACATACCAAGGAATATGAAAAATTGATGAACGGCGCTGGTGATACGATTGTACAATGTGAAACTTGTAAAAAACAACTATTGCAACGCAATCTGGACAAACACATGGCATTACATAGTAGAAAAGAACGTGAAGCAAAAGAAACTCAAACGAAATTCCTTTGCGCTTACTGTTCACGCGAgtgtaaaaaccaaaaatctCTTAATCAACACGAAAAGGCACATCAGGGTACATCACCAAACATTATTTATATATGTGATGATTGTAATCGTTCTTATGCAACGCAGCATTTATTACAACAACATCGTCGGCAAGCGCACAAAGAGCGAGATCATTTCTGTCCGATTTGCGGTAATGCTTTTAAGCTTAAAAACCAACTAAGTAATCATATGAAATTGCATTTGGAAAAGAATATACAATGTCCACATTGTGAGAAATGTTATGCACGTCGATTTGATTTAGATGTACATATGCGCACGCATACCGGAGAGCTGCCGTTCGCTTGTCATCTTTGCGATAAACGTTTCGCCATTAAAGTACGGCTAACATACCATTTACAAAAGCATTATGGCGTAAAACATCGTTGTAAAGACTGTGGTGCAGAATTTAATTCGAAGCAGAAATTAAAGGCACATAGTTATAAACATACAGGAATGCCATATCGCTGCGAAAAATGTGATGGGCATGGATTTGCTAATCGTGACGTCTTTAAACGACATTTGCAGCGCGTGCATTCTAGCAGTATGAGCGATGAAGAACTTGTTGCCATGTTTCAACAAAATACAGGCAAAACAACACGCATACGGCGTGTTAAGTACTATGAGGAGCACGTTGAGggaaaaataataagaattatTGATGATGAGTCAGGTGGCGTTGTTGGTGATGATACTTTGATTGATGCAGATGATATTGCACTTGAATCGGAGGTGATTCACAGCTGA
Protein Sequence
MVIQCRACLNTNNTAFIRMESKIADGLDFFTCFCMCTRLNAALNDGLPGILCTNCSEELQIAFNFVQNARQADTMLREVLTTKIIRGDAIETLDSQDVLIIEGSVTEAEGEVDSYVLEELLEDESDDVIEDDGNICTVEVKKINREISEESLHELDFMEGKLAIEEIVEVQAEQINTRDYYAEDESDEVYLREYQDNDNEVHSSNWNITPKGKKWKCIECKRILCGDVSYEGHMNMHRSLRPYKCGMCACAFRCKVMLERHTQFRHHQTPPDKMEEMSPSTICEICTKIFTTPTELQEHHELVHSDSSTTQCKKCTRIAPFARTEIIEHFRTEHPEDYQKHFPTVEMPLKPVTPTSWQCDVCKSYLSSEVTLQDHRNIHHNDRPHECQFCKKRFATTSNLRQHMRGVHTKEYEKLMNGAGDTIVQCETCKKQLLQRNLDKHMALHSRKEREAKETQTKFLCAYCSRECKNQKSLNQHEKAHQGTSPNIIYICDDCNRSYATQHLLQQHRRQAHKERDHFCPICGNAFKLKNQLSNHMKLHLEKNIQCPHCEKCYARRFDLDVHMRTHTGELPFACHLCDKRFAIKVRLTYHLQKHYGVKHRCKDCGAEFNSKQKLKAHSYKHTGMPYRCEKCDGHGFANRDVFKRHLQRVHSSSMSDEELVAMFQQNTGKTTRIRRVKYYEEHVEGKIIRIIDDESGGVVGDDTLIDADDIALESEVIHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01358317;
90% Identity
-
80% Identity
-