Basic Information

Gene Symbol
ZEB2
Assembly
GCA_949987695.1
Location
OX465290.1:153384123-153388638[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 2.1e-05 0.0035 19.3 2.4 2 23 261 282 260 282 0.96
2 12 0.001 0.17 14.0 4.9 2 23 360 381 359 381 0.95
3 12 0.00041 0.067 15.3 3.3 1 23 402 425 402 425 0.95
4 12 2.2e-05 0.0037 19.2 1.9 2 23 441 463 440 463 0.95
5 12 1.1 1.8e+02 4.5 0.9 1 16 474 489 474 493 0.83
6 12 0.012 2 10.6 6.9 2 23 516 538 516 538 0.95
7 12 8.1e-08 1.3e-05 26.9 0.5 1 23 544 566 544 566 0.98
8 12 0.021 3.5 9.9 1.6 1 23 572 594 572 594 0.96
9 12 0.00055 0.091 14.9 0.5 1 23 600 622 600 622 0.95
10 12 9.1e-06 0.0015 20.5 3.5 1 23 628 650 628 650 0.98
11 12 0.0013 0.22 13.7 2.1 1 23 656 678 656 678 0.98
12 12 0.00045 0.075 15.1 0.1 1 23 684 706 684 706 0.98

Sequence Information

Coding Sequence
ATGGcttcaacaaacaaacataatttcGATTGGCTGTGTCGGACTTGTATGCAAGAACTTGTTGGAGTGACCTTATTTGACGCAAACACTAAACCACAGCAACAATGGCGATCTATCGCTGATACAGTTGAGGAATGTGGCTCATTGCGGATCAGTGAATTGATATCGAATACAATATTGCATCTGGAAGTTCATCTAGGTGACGagctgccaaaaaaaatttgtcgatCATGTCTGCAGAGTTTTATAAACGCACATCGGTTACAACAGACGTGTCTAAAATCACAACAAAAGTACCACACATTGATTGCTAAACGAAATGCCGATTTAGCAATGGCGTTAACAGAGGTATCGTTTAAAGATGAGAAAAAAGTGgacgaatttttaaaacaagAACCAGTGTCAAAAGCAAGAAATAAGGGAATTGATTTTGAGTATGTTAACGCTTCAACAGTGTCTCCAATAACAGAACAAGCAGCGAAAGTTGAAATAAGctcaaatgaatttttaaatcaagaaCGTCCAGTAGCCATATATTATGGAAAGGAACTTGAGAAACTGGAAGTTACCCAATCAAATAACGATTCAGTTGAACAATATATAAAGTCGCAAGATGAATTAAGCGAATTCCTAAAAAATGAACCATGCGATGATGGAGAATGGAAAGTTGGAGATAGCCCTGGCGAGTTCGTTACAAATGAGCCATGTAATGATGTAGACAATAAAGTATTAATAGTAGAAACAGAGGAGGCACAAGCTATCTTAGACAATCCCACACTTAACTGTAGTTTATGCAATAAATCGTTTACGAGGCTGCGATATCTCAACACCCATttaaaaagtcataaaaaacCGGGTAAAGCGAAGAGAATGCATTGGAGAAATAAGCAAGTTGCTGATAATGAACCAAGTGTTGAAAGAAGTGGCGATATCGTTGCAAATGAGGCACGCAATGATGATGATAAATGTCTTGGAAATAGGAACAATGAAACAGTGCACTCAGGGGACACtgcaaaaagcaaaatatcagTAGTAGAAACAAAGGAGCAACAAATAAGCATGGGGTCTTCCGGAGTTCAGTGTCATCTGTGCTATAAAACGTTTAACCACAAACGATATTTGACAACACATTTGGATTGGCATAgaagaataaattttttggacCCCATACACTATGACAAACTGGATAAAAGTCTGCTGAAACATGTTTGTGACCTGTGTGATCAATCTTTTAGCTCGACCTTTTCATTAAAAAGGCATAACAGGTTAAAACATTCTGGCGATAAACCAAACAAACCAAATAACAGGAATAACGGGATACCGTGTGGAATGTGTCATAAAACTTTTAGTAAGCGTTTTTCATTAATCAGGCATATAAACAGTCAGCATTCTACAGAAAAAGTACTGAAAAGGTCAAAATTTATATGCGATAATTGTGGTGAAGCTTTTGTGTGTCAATCTACGCTAACGTTCCATGAACTACAGTTCGATTGTAGCAGCGACATGTCCAAGCACAAAACAAACCAAGAAGCGGTTATACCCAACGTGTGCGATTTCTGCAAAAAGAtttttaaatataGCTGTGAGCTAAGGCACCATATAAAGCATGTACACACAAGTGAGCGACCGTTCAAATGTCCCGAATGTGGCAAAGGGTTCAAAACAAAAGGCAGCCTAAGTCAGCATATTTTACGTCACAGCGAAGATAAGCCTTACGAATGCCCCTACTGTCCGCAGAGATTCAGTTGTATCGCAGATATGtccaagcacaaaaaaatacatGCAGAATTCAAACGGTTCCTTTGCGATATTTGCGGTAATAGCTTTGGCACGTCGCCTCAATTAAAGTATCATAAAATGAGGCATAGTAGTGAAAGACCGCATAAATGTGATTTTTGTGGAATGCGGTTTAATCGCGTTAAAAATCTGGGCCGTCACATGCGCACTCATACCGGTGCAAAACCATATAAATGCAAATACTGCGATCGCGCTTATGCTCAAAGTAACGATCATATCAAACATTTACGTGGTCATGTAGGTGATAAAGTTTATAGATGTGAATTATGCCCGTTGGCGTTCCGTTTAGCTTCAGAGTTGCGCTTACACTTTGCTACACATAAAAATGATGATGAAGAGACGCGTGAACGAAATATAAAAGCTTTGAAGGAAGAGGAAACTAAATTGCTGtccaaaacaacaacaccagagCAATATGGAAAATTGGCAGACATGATGGAGAGTAAGCCAGATAAAGCCAACGGTTTCCACAAGCGTCCGAAGGAAGATATCGTCGTTCCATATAGCACCTCAGCTTGCTCAATCCCCATACATGAGCGTCGTGATTGCACCCAAGATACCTAG
Protein Sequence
MASTNKHNFDWLCRTCMQELVGVTLFDANTKPQQQWRSIADTVEECGSLRISELISNTILHLEVHLGDELPKKICRSCLQSFINAHRLQQTCLKSQQKYHTLIAKRNADLAMALTEVSFKDEKKVDEFLKQEPVSKARNKGIDFEYVNASTVSPITEQAAKVEISSNEFLNQERPVAIYYGKELEKLEVTQSNNDSVEQYIKSQDELSEFLKNEPCDDGEWKVGDSPGEFVTNEPCNDVDNKVLIVETEEAQAILDNPTLNCSLCNKSFTRLRYLNTHLKSHKKPGKAKRMHWRNKQVADNEPSVERSGDIVANEARNDDDKCLGNRNNETVHSGDTAKSKISVVETKEQQISMGSSGVQCHLCYKTFNHKRYLTTHLDWHRRINFLDPIHYDKLDKSLLKHVCDLCDQSFSSTFSLKRHNRLKHSGDKPNKPNNRNNGIPCGMCHKTFSKRFSLIRHINSQHSTEKVLKRSKFICDNCGEAFVCQSTLTFHELQFDCSSDMSKHKTNQEAVIPNVCDFCKKIFKYSCELRHHIKHVHTSERPFKCPECGKGFKTKGSLSQHILRHSEDKPYECPYCPQRFSCIADMSKHKKIHAEFKRFLCDICGNSFGTSPQLKYHKMRHSSERPHKCDFCGMRFNRVKNLGRHMRTHTGAKPYKCKYCDRAYAQSNDHIKHLRGHVGDKVYRCELCPLAFRLASELRLHFATHKNDDEETRERNIKALKEEETKLLSKTTTPEQYGKLADMMESKPDKANGFHKRPKEDIVVPYSTSACSIPIHERRDCTQDT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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