Math033492.1
Basic Information
- Insect
- Mellicta athalia
- Gene Symbol
- X-element\ORF2
- Assembly
- GCA_905220545.1
- Location
- HG992199.1:720791-733830[+]
Transcription Factor Domain
- TF Family
- THR-like
- Domain
- zf-C4|THR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 1.1e-24 2.8e-21 77.4 0.0 13 140 903 1029 895 1058 0.90 2 9 0.00054 1.3 9.8 0.0 106 140 1089 1122 1086 1151 0.86 3 9 0.00054 1.3 9.8 0.0 106 140 1182 1215 1179 1244 0.86 4 9 0.00054 1.3 9.8 0.0 106 140 1275 1308 1272 1337 0.86 5 9 0.00054 1.3 9.8 0.0 106 140 1368 1401 1365 1430 0.86 6 9 0.00054 1.3 9.8 0.0 106 140 1461 1494 1458 1523 0.86 7 9 0.00054 1.3 9.8 0.0 106 140 1554 1587 1551 1616 0.86 8 9 0.00054 1.3 9.8 0.0 106 140 1647 1680 1644 1709 0.86 9 9 0.00042 1.1 10.2 0.0 106 141 1740 1774 1737 1777 0.90
Sequence Information
- Coding Sequence
- ATGCATCCTGACGGTAAAGCATATGGTGGTTCAGCTATCCTTATCAAAGCTAATATAAGACATTACCAGAGTCAATCATACTGCAAGAACTACATCCAGGCAACCAACGTTGTAGTGTATGACTGGATTAGCAAGATTACTGTATCAGCCTTGTACTGCCCCCCAAgacataaaattaaagaaagtcAATTCTGCGACTACTTCAATATCTTAGGCCATCGCTTTATAGCAGCAGGTGATTACAACGCCAAACATACTTTTTGGGGGTCTAGGCTCGTCCAATCTAGGGGCCGGGAACTGTTAAAATGTATTCAAACAAATAGTCTGGATGTTGTTTCCACGGGTCAGCCGACATACTGGCCTTCGGACAGAAGTAAAATACCAGATCTTATTGACTTCGGTGTCACCAAAGGGATtgcgaaaaataaaatgttgtgtAATAGCTGCTGGGATTTATCATCAGATCACTCTCCCATTATTATCAGTGTTGAGTCTGAAATCCAGTCAAACCCGATGCCCATTATGTCGCTCCAAACATATTGGGACTTAATCaaggaaaaaagaaaaatgaggAAATTATGGCAACAGAATAGATGTCCTGATACGAAAAAACGATTAAACCACAAAGTAAAAGAACTGAAACAAGCACTGGAACAAGATCGAAACGCTTCGTTTCAAGCGTATCTGGGGGGCCTTGATGGAACAGCAGCCTCGGACTACTCCCTTTGGAAGGCCGCTAGGAAAATTAAAAGACCTGTGCTGTCAAGCCCAGCACTTAGAAAAACAGATCTCAGTTGGGCACGCAGCGACCAGGAAAAGGCGGACACATTTGCAGAGCACCTTGTAAAGGTTTTTCAACCCCATCCATACGAAGGTTCACCCGAGCATGAAAGaaaaattattgaatttattgATGCACCTGACCAGGATGACATCGAACCTGACCAATTCACTAAAAGTGAAGTAAAAAaagcaattaaaatattaaagtccAGGAAAGCTCCAGGCTATGACCTAATTACCAACAAAGTCCTGCAGGAATTACCAGAGTCTGGGATAGCATTGCTCACAGCCATTTATAATGCTATCACTAAACAAAAATTCATCCCAATCCAATGGAAGGTCGcacaaataataatgcttttgAAGCCAAACAAACAACCTGAGGACCCGAGATCATATAGGCCGATTAGCTTATTACCCATACCTGCGAAAATGTACGAATCGCTACTATCACTCCGACTGACACCGTTCATAGAACAGCGCAATTTGATCCCCAAACACCAATTCGGATTTCGTCGAAATCATGCTACAGTCGAACAGGTACACAGGCTAATTAGCGAAATTGACAAGGCCTTTGAATCTAAAAAAATATCTCAAGCCTTTGATAGCGTGTGGCATGAGGGCCtgttgtataaattaaaatcattacTCCCTAACTACATGTACAGAATCCTGAAATCGTTTTTAGAAAACAGACATTTCCTGGTCCAAAATGGCGAGGCGCTCTCAAGTCTCTGCCCTGTTAGAGCAGGGGTACCACAGGGCAGCGTGCTGGGCCCAACGTTGTACCTTATCTATACATCTGACATACCAACTTCAGAGTGCATCACCACGGGTACCTTTGCTGACGACACTGCGATTTTGGCATCTCACTCTGACCCGGCTACGGCGGCAGAACTTTTACAAGGTGGACTTAATGACATATCGATCTGGTTAAAAAAGTGGAGAATTAAGGctaatgaaacaaaatctaTTAATGTTACTTTTACATTAAGAAGAGGCATTTGTCCACCCGTCAGACTCAACAACTTAGAGGTTCCACAAGCAAACCACGTCAGGTATTTGGGATTGTATCTTGATAAACGACTTACCTGGcaaaaacacattttcacaAAACGTAAACAATTAGGGCTTCAACTGCGTGGGCTCTATTGGTTGATGGGTCGCCGGTCACAATTGTCGCTAACCAGCAAGCTTCTTTTATACAAAACGATCCTTAAACCAATTTGGACCTACGGAATACAACTCTGGGGGACAGCTTCCCAATCCAACATTGAAATCTTGCAACGATTCCAAAACAAAATATTGAGAATGATGACTGGTGCCCCCTACTACGTGACAAACGAGCAACTACATCACGACTTGCACATGAGAACAGTCAAACAGGAAATACTCTTCCATACAAACATGTACAAGAAAAGAATTGAACGCCATCCGAACAGCCTGACCAATACCTTGATGAAGGAAACCATTACAACACGTAGATTGAAACGGAAGATGCCCCAAGACACACTTAAgttaTCAATATTAACCAACGGTGAGAACGTAGCGCCCGTGTACGACAGAGAGGCCAAAGACCAACATGTGTGTGAAGAAATGCCATCGACGAGCAGCAACCCTGACGTCAACAAAGCTAGGGACATCCTGCAGGATGTTGAGAGGATAGAGCCAAATTCGATGGAGTCGATACTATGTGAAGCGATCAAACTGGAATTCGAAGCGTACACCTCAATTAGCAGTTGTAGCGGATCATCTCGGGAACTTAATGAGGTTGAAAGAGCAAAACTGAATGAACTCATCGTAGCTAACAAGGCATTGAACGCTCCCATCGACGATGACATCTCACAGCTCATCGGAGATACAACTAACGTGGGGCTTAAGGACGACGGTAACAAACACGATCCGCGATTGATAACTTTAGTGAACCTGACCGCGGTCGCGATACGTAGGCTGATTAAGATATCGAAGAAGATCAACGCCTTCAAGAACATGTGTGAAGAGGACCAGGTGGCGCTGTTAAAGGGTGGCTGTATAGAAATGATGGTCCTTCGAAGCACGATGACGTACGACGGACAAAGAAATCAATGGAAGCTGCCGCACAACCACGAGCAGTTCGGCAGCATCCGCACGGACGTGCTGAAGCTGGCGCCGGGCGACATCTACCGCTCGCACGAGGCCTTCATCCGGTCCTTCGCGCCGCGCTGGCGGACCGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGGTGTGTGGGCCGTGTGTGTGCTAGTGAGCGGGCGAGAGTGTGTACTAGTGACGGACGAGAACGTCATCCTCATCATGTCCGCCATCCTGCTGTTCTCGCCCGACCGGCCGCGTGTGGTGCACCGGGACGTCATCAAGCTGGAGCAGCGGTCGGGAATGTGTCCCAGTGAGCGATGGTCGGGAATGTGTGCCAGTGAGCGGTCGGGAATGTGCACTAGTGTGTGGTGGGGAATGTGTTGTAGTGAGCGGTCGGGAAGGTGTGCTAGTGAGCGGTGGTGGGGAATGTGTATAGTGAATGGTCAGGAATGTGCACTAGTGAGTGGTCGGGAATGTGTGGTAATGAGCGGTCGAGAAAATGTGCTAGTGAGCGGTCTGGAATGTACACTAGTGAGTGGTCGGGAATGTGTGGTAGTGAGTGGTCGGGAAAATGTGCTAGTGAACAGTCTGGAATGTGTACCAGTGGCGGTCGGTAATGTGTCCTAG
- Protein Sequence
- MHPDGKAYGGSAILIKANIRHYQSQSYCKNYIQATNVVVYDWISKITVSALYCPPRHKIKESQFCDYFNILGHRFIAAGDYNAKHTFWGSRLVQSRGRELLKCIQTNSLDVVSTGQPTYWPSDRSKIPDLIDFGVTKGIAKNKMLCNSCWDLSSDHSPIIISVESEIQSNPMPIMSLQTYWDLIKEKRKMRKLWQQNRCPDTKKRLNHKVKELKQALEQDRNASFQAYLGGLDGTAASDYSLWKAARKIKRPVLSSPALRKTDLSWARSDQEKADTFAEHLVKVFQPHPYEGSPEHERKIIEFIDAPDQDDIEPDQFTKSEVKKAIKILKSRKAPGYDLITNKVLQELPESGIALLTAIYNAITKQKFIPIQWKVAQIIMLLKPNKQPEDPRSYRPISLLPIPAKMYESLLSLRLTPFIEQRNLIPKHQFGFRRNHATVEQVHRLISEIDKAFESKKISQAFDSVWHEGLLYKLKSLLPNYMYRILKSFLENRHFLVQNGEALSSLCPVRAGVPQGSVLGPTLYLIYTSDIPTSECITTGTFADDTAILASHSDPATAAELLQGGLNDISIWLKKWRIKANETKSINVTFTLRRGICPPVRLNNLEVPQANHVRYLGLYLDKRLTWQKHIFTKRKQLGLQLRGLYWLMGRRSQLSLTSKLLLYKTILKPIWTYGIQLWGTASQSNIEILQRFQNKILRMMTGAPYYVTNEQLHHDLHMRTVKQEILFHTNMYKKRIERHPNSLTNTLMKETITTRRLKRKMPQDTLKLSILTNGENVAPVYDREAKDQHVCEEMPSTSSNPDVNKARDILQDVERIEPNSMESILCEAIKLEFEAYTSISSCSGSSRELNEVERAKLNELIVANKALNAPIDDDISQLIGDTTNVGLKDDGNKHDPRLITLVNLTAVAIRRLIKISKKINAFKNMCEEDQVALLKGGCIEMMVLRSTMTYDGQRNQWKLPHNHEQFGSIRTDVLKLAPGDIYRSHEAFIRSFAPRWRTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQVCGPERARVCTSDGRERHPHHVRHPAVLARPAACGAPGRHQAGAGVWAVCVLVSGRECVLVTDENVILIMSAILLFSPDRPRVVHRDVIKLEQRSGMCPSERWSGMCASERSGMCTSVWWGMCCSERSGRCASERWWGMCIVNGQECALVSGRECVVMSGRENVLVSGLECTLVSGRECVVVSGRENVLVNSLECVPVAVGNVS*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -