Basic Information

Insect: Mellicta athalia
Gene Symbol: ewg
Assembly: GCA_905220545.1
Location: HG992178.1:2872368-2881834[-]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 3.3e-89 3.1e-85 286.6 0.1 1 187 79 272 79 283 0.94

2 7 2.9e-18 2.8e-14 54.7 1.9 129 187 361 420 349 431 0.84

3 7 2.9e-18 2.8e-14 54.7 1.9 129 187 509 568 497 579 0.84

4 7 2.9e-18 2.8e-14 54.7 1.9 129 187 657 716 645 727 0.84

5 7 4.6e-18 4.4e-14 54.1 1.7 129 187 805 864 793 875 0.84

6 7 1.7e-18 1.6e-14 55.5 1.6 128 187 952 1012 940 1023 0.84

7 7 0.0015 14 6.7 0.1 128 158 1100 1131 1088 1134 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	3.3e-89	3.1e-85	286.6	0.1	1	187	79	272	79	283	0.94
2	7	2.9e-18	2.8e-14	54.7	1.9	129	187	361	420	349	431	0.84
3	7	2.9e-18	2.8e-14	54.7	1.9	129	187	509	568	497	579	0.84
4	7	2.9e-18	2.8e-14	54.7	1.9	129	187	657	716	645	727	0.84
5	7	4.6e-18	4.4e-14	54.1	1.7	129	187	805	864	793	875	0.84
6	7	1.7e-18	1.6e-14	55.5	1.6	128	187	952	1012	940	1023	0.84
7	7	0.0015	14	6.7	0.1	128	158	1100	1131	1088	1134	0.75

Sequence Information

Coding Sequence: ATGGTCCGGGAGAGTCAGGGGGATTCGGACTACAGCAACATGAACTCGGCCGTGAGCTCGGAGTCTATGGATTTGGCTGAGGAGGACATGTCGCAAGTGGACGGGTGCGGGCTGAGCGGCGGCTCGGAGGACGAGGACGAGTGCGCGTCGTCGCCGGCCGGCTCCGCCTACGAGGACGCGGACGTCGCCAAGAGCGCCATGAGCGACGAGGTCACCAAGCAGCTGGCGGCCGCCGGGCCAGTCGGCATGGCCGCGGCTGCCGCAATAGCGTCGTCAAAGAAACGCAAGCGACCACACTCCTTTGAAACAAATCCATCCGTTAGGAAGAGACACCAGAACAGGCTGCTCAGGAAACTTAGACAAACGATCGAGGAGTTCGCGACGCGCGTGGGCCAGCAGGCCGTGGTTCTGGTGGCGACGCCGGGCAAGCCCAACACGTCGTACCGGGTGTTCGGCGCCAAGCCGCTGGAGGACGTCGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCAGCAGTTCGGGCTGGGCGGGTGCCCGCaggcgccgccgccgccgctggACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACGCCCGTCGAGAAGATGACGCAGGCGCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAACGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAACGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAACGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAACGTACGAACCATCCGCTTGTCAACATTATTGGTCAGTGCGCGGCAAGCCGGGGTGGGGGCGCGAGTCGGGTcaggtgctgtaa
Protein Sequence: MVRESQGDSDYSNMNSAVSSESMDLAEEDMSQVDGCGLSGGSEDEDECASSPAGSAYEDADVAKSAMSDEVTKQLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQFGLGGCPQAPPPPLDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAEGTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRRYEPSACQHYWSVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAEGTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRRYEPSACQHYWSVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAEGTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRRYEPSACQHYWSVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAEGTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRRYEPSACQHYWSVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQNVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAEGTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRTYEPSACQHYWSVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKVRTIRLSTLLVSARQAGVGARVDAAAVVAQGPAVGQRAHGRALRGREAERTNHPLVNIIGQCAASRGGGASRRGRRGGPRTCRGPTCAWTRAPRTRSRTYEPSACQHYWSVRGKPGWGRESGQVL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -