Basic Information

Gene Symbol
-
Assembly
GCA_905220565.1
Location
HG992236.1:8824622-8835157[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00055 0.059 14.6 1.5 1 23 235 257 235 257 0.98
2 10 1.3 1.4e+02 4.0 0.2 3 23 282 303 280 303 0.92
3 10 0.00063 0.067 14.4 0.4 2 23 325 346 324 346 0.95
4 10 0.00056 0.06 14.6 1.1 1 23 350 372 350 372 0.98
5 10 0.0044 0.47 11.8 0.2 1 23 379 402 379 402 0.95
6 10 2.8 3e+02 3.0 0.2 3 23 410 431 408 431 0.84
7 10 5.2e-05 0.0056 17.8 1.7 1 23 437 460 437 460 0.97
8 10 0.00011 0.012 16.8 1.4 1 23 466 488 466 488 0.98
9 10 2.2e-06 0.00023 22.2 1.0 1 23 494 516 494 516 0.99
10 10 3e-06 0.00032 21.7 5.9 1 23 522 544 522 545 0.96

Sequence Information

Coding Sequence
ATGGAAAACGTAATTGTGTCTAAGAAAAATCAGGGTCCTTTAATAGATCCCGCGCTGTGTCGATGTTGTCGTTCTATTAAAAAATGTCGCCTTTTAACATCGGAATATGAATTTATGGGAGCGAAGGAAGTTTACTCTGATATGTTTATGGATGTTTTTGGCTTGCTTTTATCGCATTTAGAGGAAGATAGCAAGGAATCATGCATATGTGCTACATGCGTGTCTCGTCTACGTGAAGCATGTGCTTTTCGACGGCAAGTACTGCAGTCTGAGCAAATGTTTTTAGAGGCTCGATTGCAGAATAAAGATGATACTGAGCAAAATCTAAAAGTGGAAATAAAAATGGAGCCCCCCTGCGAACCTGATTGTAATGACGTTGCTGATATGCAGGATGATCAGTATGAAGATGATGACATTGATACTAAGTTAGATACCCAAATACCAATAAAAGAAGATACTTTAGAGCGGAAAATGTCGTTAAGAAAAACGAGAAACAGTCAGAAGAGCAAAGTCGGTAAAGAATTGAGTAGTAAAAAAATGCAGAAATTAAGAATGAAATTGGATAAATTGATAAAAACAGATCCACCTCAGCCGAAGAAATTGAAGAAGCAGACCATCGACCACGACCAGATGGCCTACACCAACACAGTGACAATAGTTCACAATTCATATGTTTGTCCCTTCCACAACCGCATCAGTTTCTACTACTGCTACTATTGCAAGGATCAGTTTACAAATCCCAGTGAGTTGAGAGACCACACACTATCCCATGACCCAAAAGAATTGTTCGAAGATACAACAGAAAACAAGAAACCACCAAAAATCGATATTACTAGAATCGACTGCAGGCTCTGTTCAGAAAAAATCGACGATCTCGATACATTTAAAACGCACATCACTAACGTCCACGGCAAGGTCATGTACCCGGTCACCAATGAATTTTTAAAGTTTCGCCTTACATTAAACAATTTGACTTGTACTGAGTGTACTAGTGTGTTTCCTTACTTTGATTCTTTAAAAAAACATATGATCGACCATTTTGGCACGTTCACCTGTGATATGTGTGGAGCGTGCTTTTTAGAACAGGCATCCTTGAGAACCCATATAAACAAACATAAGAAGGTAGATGTGAATTTTCCATGTGAGGTCTGCGGTAAGAATTTGAAGTCAAAATACAGCAGGAGCTTGCATGTAGCCACTGTGCATGAAAAAAGGCCATTTGTCAATTGTTATAAATGCGATGCAACATTTCTATCCTACGCTCTTCGTAACCGTCACTTGATAGAAGTGCACGGTGACAAACGTACGTTCCCTTGTAAGTTATGTGACAAAGTTTACAATAGAAGAAAAACTTTAATGGAGCATAATAGACGAAACCATTTAAAGGTGTACAGGCATCAGTGCGATCTCTGTGATCAGAGGTTTTACTTGCCATCTCGGTTGAAGGAGCATATGGCAACGCACACAGGTGAAAGAAATTTTAGATGTGAGTTCTGCGATAAAAGCTATCCTCGGTTGCAATCATTACAAGAACATATAAGATCTCACAGCAGCGAGAAGAGATACAAGTGTGACGTCTGCAATACGTCGTTCACTCAGTGCGGTAGTCTGAAGAATCATATGAAGAGTCATCACCAAGTGTTTGAAATGGAGGGAAGCTTTAATTAA
Protein Sequence
MENVIVSKKNQGPLIDPALCRCCRSIKKCRLLTSEYEFMGAKEVYSDMFMDVFGLLLSHLEEDSKESCICATCVSRLREACAFRRQVLQSEQMFLEARLQNKDDTEQNLKVEIKMEPPCEPDCNDVADMQDDQYEDDDIDTKLDTQIPIKEDTLERKMSLRKTRNSQKSKVGKELSSKKMQKLRMKLDKLIKTDPPQPKKLKKQTIDHDQMAYTNTVTIVHNSYVCPFHNRISFYYCYYCKDQFTNPSELRDHTLSHDPKELFEDTTENKKPPKIDITRIDCRLCSEKIDDLDTFKTHITNVHGKVMYPVTNEFLKFRLTLNNLTCTECTSVFPYFDSLKKHMIDHFGTFTCDMCGACFLEQASLRTHINKHKKVDVNFPCEVCGKNLKSKYSRSLHVATVHEKRPFVNCYKCDATFLSYALRNRHLIEVHGDKRTFPCKLCDKVYNRRKTLMEHNRRNHLKVYRHQCDLCDQRFYLPSRLKEHMATHTGERNFRCEFCDKSYPRLQSLQEHIRSHSSEKRYKCDVCNTSFTQCGSLKNHMKSHHQVFEMEGSFN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2