Basic Information

Insect: Melitaea cinxia
Gene Symbol: -
Assembly: GCA_905220565.1
Location: HG992235.1:10110484-10121223[+]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.0011 4.4 7.8 0.0 2 26 196 220 195 224 0.94

2 12 0.0011 4.4 7.8 0.0 2 26 306 330 305 334 0.94

3 12 0.0011 4.4 7.8 0.0 2 26 416 440 415 444 0.94

4 12 0.0011 4.4 7.8 0.0 2 26 526 550 525 554 0.94

5 12 0.00083 3.3 8.3 0.0 2 27 636 661 635 664 0.93

6 12 0.0011 4.4 7.8 0.0 2 26 856 880 855 884 0.94

7 12 0.0011 4.4 7.8 0.0 2 26 966 990 965 994 0.94

8 12 0.0011 4.4 7.8 0.0 2 26 1076 1100 1075 1104 0.94

9 12 0.0011 4.4 7.8 0.0 2 26 1184 1208 1183 1212 0.94

10 12 0.0011 4.4 7.8 0.0 2 26 1294 1318 1293 1322 0.94

11 12 0.0011 4.4 7.8 0.0 2 26 1404 1428 1403 1432 0.94

12 12 2.5e-22 9.8e-19 68.7 0.0 28 196 1491 1674 1479 1676 0.80

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.0011	4.4	7.8	2	26	196	220	195	224	0.94
2	12	0.0011	4.4	7.8	2	26	306	330	305	334	0.94
3	12	0.0011	4.4	7.8	2	26	416	440	415	444	0.94
4	12	0.0011	4.4	7.8	2	26	526	550	525	554	0.94
5	12	0.00083	3.3	8.3	2	27	636	661	635	664	0.93
6	12	0.0011	4.4	7.8	2	26	856	880	855	884	0.94
7	12	0.0011	4.4	7.8	2	26	966	990	965	994	0.94
8	12	0.0011	4.4	7.8	2	26	1076	1100	1075	1104	0.94
9	12	0.0011	4.4	7.8	2	26	1184	1208	1183	1212	0.94
10	12	0.0011	4.4	7.8	2	26	1294	1318	1293	1322	0.94
11	12	0.0011	4.4	7.8	2	26	1404	1428	1403	1432	0.94
12	12	2.5e-22	9.8e-19	68.7	28	196	1491	1674	1479	1676	0.80

Sequence Information

Coding Sequence: ATGAAAGGGTCAAATATTACTCAAGTAGGATTCAAAGAATTTGAGTCTAATTCTTGCACTGTCCCGACAGCGGTTCAACACGAGCGGAAGCCGATCGTGGACAAGTCAAAGGGCGATGAGCGCCAGTCTTCCGCCTACTCCAACCTCCTGGGGCAGGGCTCCCAGTTAAATACCAAAGATGAAGCGAACGACGCGTTTGGCGCCGTCACACCCGCTACACCAGCGTTCAACTTAGCGCTGGCTGCAGCTGTGGCCTTAAATAAAGGTAGTTCTGTGGCTCCGTACCTCGCAGCGGGTAACCCCGGCGATGTAGAAGGTGCAAGACGACAGCAGATCATCATACAGGCGCAGCTGGCGAAAAACTTGTTCAAGATGGGACAGTTTGGTGCAATAAACGAATACCTGCAATCAGCGTATAACAATGCAGACCTGCAGTCCACGGCCTCCGCCCCGCCCGCGGCCTCTACCCCCGCCGTTCCAGGCGACGATGACGGTGCTTGTGACGTGCTGAGTACTCCGGAAAGCGTTCAGCTACCGCTGAGTGTGCCCGCCTGCCCGAACCCTGCGCTGCGCTTACACGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACACACACGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACACACACGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACACACACGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACACACACGCCACCTGCGAGAGCGCCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGCTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACGCGCCACCTGCGAGAGCGCCTCGCGCCTGCTCGCCGCGCTGGCGCGTTGGGCGCTCGCGGTGCCACACTTCGCCGCCATGCCGTACGTACACACACACATACACACACACACACACGCCACCTGCGAGAGCGCCTCGCGCCTATTCGCCTCGTTGGTTTGAGATCCAGACGGGGCTGCTCCGCAAGTGCTGGCCGGAGTTGTTCGTGCTGGGGCTCGCTCGCTGGGCGGCGCCCATGGGGCTGAACATCATGCTGCCCATGCTGACGACGAACCTGCGGGCAGAACTGCGGGAGCGCTCGGAGCGACCCGCGCCCCGCCCGCCCCCGCCCTCCACCGAGATCACAATAGAAGACTACTCAGACGAACGCATCACGGAAGTGTTAGACCTAATGGGTCGTCTGCAGAAGTTTATAGCGTACATGGAACAACTGCAGGTTTCAGACCGCGAACACGCGCATCTACGTGCTCTGTGTCTCTTCTCCTCGGATGGTGCACCAGAATTCCTAATCCAAAAACTCGAAGAGCTACAGTCTAAAGTGATGCGTTCTCTGAAAACAACTTGCCAACTCAACGAAGATAGACTCGAGAAAATAATGCTGAAGCTGCCCAATCTGCGTAACTTTACTGGGAGCTTTCTCGAAGATGTGTTCTTTGTCGGTTTCCTTGGCGACATATGTATGGATGACGCTATACCGTATTTACTTTCTGGTGAACGTTAA
Protein Sequence: MKGSNITQVGFKEFESNSCTVPTAVQHERKPIVDKSKGDERQSSAYSNLLGQGSQLNTKDEANDAFGAVTPATPAFNLALAAAVALNKGSSVAPYLAAGNPGDVEGARRQQIIIQAQLAKNLFKMGQFGAINEYLQSAYNNADLQSTASAPPAASTPAVPGDDDGACDVLSTPESVQLPLSVPACPNPALRLHATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPXXXXXXXXXXXXXXXXXXXRAGALGARGATLRRHAVRTHTHTHTHTRHLRERLAPARRAGALGARGATLRRHAVXXXXXXXXXXXXXXXXXXPRWRAGRSRCHTSPPCRTYTHTYTHTHTPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRXXXXXXXXXXXXXXXXXXXALARWALAVPHFAAMPYVHTHIHTHTHATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHTHATCESASPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRAGRSRCHTSPPCRTYTHTYTHTRHLRERLAPARRAGALGARGATLRRHAVRTHTHTHTRATCESASRLLAALARWALAVPHFAAMPYVHTHIHTHAPPARAPRACSPRWRVGRSRCHTSPPCRTYTHTYTHTHTPPARAPRAYSPRWFEIQTGLLRKCWPELFVLGLARWAAPMGLNIMLPMLTTNLRAELRERSERPAPRPPPPSTEITIEDYSDERITEVLDLMGRLQKFIAYMEQLQVSDREHAHLRALCLFSSDGAPEFLIQKLEELQSKVMRSLKTTCQLNEDRLEKIMLKLPNLRNFTGSFLEDVFFVGFLGDICMDDAIPYLLSGER

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -