Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.6e-05 0.0022 18.0 1.1 1 23 194 216 194 216 0.96

2 5 0.00011 0.009 16.1 1.2 1 23 223 245 223 245 0.97

3 5 0.00011 0.0095 16.0 1.1 1 23 251 273 251 273 0.98

4 5 1.1e-05 0.00092 19.2 4.5 1 23 279 301 279 301 0.98

5 5 0.00037 0.031 14.4 0.1 1 22 307 328 307 328 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.6e-05	0.0022	18.0	1.1	1	23	194	216	194	216	0.96
2	5	0.00011	0.009	16.1	1.2	1	23	223	245	223	245	0.97
3	5	0.00011	0.0095	16.0	1.1	1	23	251	273	251	273	0.98
4	5	1.1e-05	0.00092	19.2	4.5	1	23	279	301	279	301	0.98
5	5	0.00037	0.031	14.4	0.1	1	22	307	328	307	328	0.95

Coding Sequence: ATGAAACAATCGACAGACTACGCAAAATCTTGCACGTCGAACGGTGGAATTTGTAGGTTATGCCTTCGCGTTGGGGACCGTTTAGTGCCGATATTCGCCGAGGAAGAAACATCGAAACAGCTGCTTTCTCGCATTTGGGATTGCTGTCCCATTACGCTGTTCGAAAACGACGACCTACCGAAGACGATCTGTCGCGAGTGCGAGGAAAAGATAGCAGTCACGTTCGAGTTTCGTGAGCTATGCAGGAAAACGGAACGCATCTTGAAATTACAATACGATTTGCGCCGCTCGAACGAATCCAACTGGAGGATTGCGTCGGATTGCAACGTTGAAAAGAACTCGAAAGCAGAGGAGGATGGGTCAGCGTACAAACGAACAGACGAGAAGAACGAGCAAGCGTTCGAAGGAGAACAGCAGGACTGGGATCGCGTTCGGAAAAATTCGGAAATCGCTGGTAGCGAAGACGCAGcagaaaaaaatgacgaagaTGCCGCAACAGGAAAAAACAGTGGTGGCGTCGATGGTAGCGGTAATGTACAAAGTTACGACGACAGAGTGGCATCCGTGACAGAAATCCGATACCTGTGCGACGTCTGCAGTAAAACGTTCGCCTCCAAGTCCGGGCTGCGATTTCACATGAAGTCGCACAGTTCAGCCGCGAAGGCTCATCCGTGCCGACACTGCGGCAAAGGATTTGCGATCCCGAGTTACGCGAGAAGGCATGAGAGAATTCACGCCGGTGACAAACGATTCGTCTGTCATTTTTGTAGCGCGGCGTTCGCCTCCTCGAACGGTTTGAAATATCACTTGAGGCTGCATTCCGGTGAGGCAAATTACCACTGCGAAACTTGCGGCAAGTCCTTCTATCGACGGAAGTATTTAAACGAGCACGTGTTCACGCACACAGGGGAGAGACCGTACGTTTGCAAGGCATGTGGCGCTTCTTACGCGAGCTCTGGCAGTCTGTTCGTCCATCAAAAACGATGCaagaataaatag
Protein Sequence: MKQSTDYAKSCTSNGGICRLCLRVGDRLVPIFAEEETSKQLLSRIWDCCPITLFENDDLPKTICRECEEKIAVTFEFRELCRKTERILKLQYDLRRSNESNWRIASDCNVEKNSKAEEDGSAYKRTDEKNEQAFEGEQQDWDRVRKNSEIAGSEDAAEKNDEDAATGKNSGGVDGSGNVQSYDDRVASVTEIRYLCDVCSKTFASKSGLRFHMKSHSSAAKAHPCRHCGKGFAIPSYARRHERIHAGDKRFVCHFCSAAFASSNGLKYHLRLHSGEANYHCETCGKSFYRRKYLNEHVFTHTGERPYVCKACGASYASSGSLFVHQKRCKNK

Sequence clustering based on sequence similarity using MMseqs2