Basic Information

Gene Symbol
-
Assembly
GCA_963082815.1
Location
OY720425.1:48444737-48454551[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 0.00057 0.13 15.2 1.0 1 23 7 29 7 29 0.97
2 28 0.00094 0.21 14.5 0.6 1 23 34 56 34 56 0.98
3 28 0.00024 0.053 16.4 0.1 1 23 62 85 62 85 0.93
4 28 0.00018 0.041 16.8 3.6 1 23 90 112 90 112 0.98
5 28 0.00043 0.097 15.6 1.6 1 23 132 154 132 154 0.97
6 28 2.4e-05 0.0053 19.6 2.4 1 23 160 182 160 182 0.98
7 28 1.9e-05 0.0043 19.8 2.0 1 23 188 210 188 210 0.98
8 28 1.6e-05 0.0036 20.1 0.4 1 23 216 238 216 238 0.98
9 28 0.00083 0.19 14.7 5.1 1 23 394 416 394 416 0.99
10 28 0.00013 0.028 17.3 2.0 1 23 422 444 422 444 0.97
11 28 0.0027 0.61 13.1 9.2 1 23 449 471 449 471 0.98
12 28 3.2e-06 0.00073 22.3 0.4 2 23 478 500 477 500 0.96
13 28 0.0012 0.28 14.2 0.2 1 23 505 527 505 527 0.97
14 28 0.00038 0.085 15.8 4.2 1 23 561 584 561 584 0.96
15 28 9.8e-06 0.0022 20.8 0.4 1 23 591 613 591 613 0.98
16 28 2.1e-06 0.00048 22.8 5.1 2 23 620 641 619 641 0.98
17 28 2.4e-07 5.5e-05 25.8 2.9 1 23 647 669 647 669 0.99
18 28 0.0011 0.26 14.2 2.0 1 23 675 698 675 698 0.96
19 28 0.0016 0.35 13.8 5.2 2 23 726 747 725 747 0.96
20 28 0.00029 0.064 16.1 3.4 1 21 753 773 753 775 0.92
21 28 0.16 36 7.5 3.0 1 23 781 803 781 803 0.97
22 28 0.001 0.23 14.4 0.7 2 23 810 832 809 832 0.96
23 28 0.0002 0.045 16.6 0.2 1 23 837 859 837 859 0.97
24 28 6.8e-05 0.015 18.1 2.5 1 23 869 891 869 891 0.98
25 28 0.00012 0.026 17.4 0.1 1 23 898 920 898 920 0.97
26 28 1.5e-05 0.0033 20.2 0.4 2 23 927 948 926 948 0.96
27 28 4.8e-07 0.00011 24.9 1.8 1 23 954 976 954 976 0.99
28 28 0.043 9.7 9.3 1.8 1 23 982 1005 982 1005 0.96

Sequence Information

Coding Sequence
ATGCTAAGGAAAGGTGATTTCTCATGTGCCGTTTGTGATAAAACATGCGAAACAAAGAGAGAACTTTGGGATCATGAAAAAATACACGGAAAGAAAAATTTCGAATGTAATATATGtggtaaaattattataaataaatttaaattgatccTGCATAAGAAACGACACGCTAAAAGTTACTCGTTCACTTGTTCGGAATGTGGAAAAGGTTATTACTCGGCCATGAATCTTCAGGTACATTCGGAAGTTGCACATAAAGGAGTTCGGTACTCATGCGAACGTTGTGGTAAAATATTCAAGGATAGAAATTACTTCCATGTACATTTAAGGAATCACGATGGATTGTCACAAGACAGACAGCAACAGAAGAAGGGAGCCAAAGAGAAGCGTAAACACGTGTGCCATAAATGTGGAAAGCAAATTTCATCAGCTTTCGCTTTGAAAGTTCATCTTAATGTTCACGGAGGCCGGAAGCCATACGAATGTGTGACTTGTGGCAAATGTTTCGCTTCACCTTCTGCGTATAATGTTCATCATCGACAGCATACAGGAGCAAGGCCGTATACGTGTAAACTATGTAATAAATCGTTTACTATTAAACATTCACTCGTGGTACATATTCGTGCCCATGTCGGTGAAAAACCTTACATTTGTGAGATTTGCCAGAAGGGATTTGCGTCACGTTCGAGACTAAATAAACACGTTCTAACCCATGGTAGTTTCTTAGGTTCTGAAGAAAAAGTTAAACCACACGTATGTGCCTATTGTTACAAAAGcTGTTTATATCACGAAAACAACTTATATACACCAAATTTTGATCCGATTACCACCGCACAAACGGAAGCACTAAATGTTGGTGCAAAATACTTACTAACACTTGCCGATTCAAAACCATCGTCGAATCTTTCCGACGTGAATCTTCTAGAAAGTGCTGAAGATCAGTTAAACGATACTGATcgtgaattattaaatttgttagcaGCAGAAGAGGATTGCTcagatattttgcaaaatattgcTAGTAacgagaattttgaaaatttaattaacgaagGAACTTCTTTTGGACAAGAAACTGTCATTGAAGATTTCACTAgtacaattaaaaatgttaccGCAGAAGTTAGCAAGGAAGAAATATCATACGGAGTAACAGTAAAGCAAAAGAAAGTGGGTAAATTCAAGTGCGACCAGTGTGACAAATTATGTACTacgaagaaattattaaaatatcatttgATGACTCATTTTGGTATTCGACAACATTCGTGTGAAATTTGCGGAAAAACTTTCAAGCTTAAGTACGAGGTTACCATTCATAAGTTGACTCACGGTAAACCCATGTTTCAGTGTGATATTTGTTCGAAAATGTTCGTGCATAAATCACATTTAACATGTCATAGACGTAGACATACGGGTGATTACGTAGTGTACTGTAATGATTGTGGTAAAGGATTCGTTACACAATCCTCTTATAGAAATCATGTTAATACCCAGCATAATAAACTTTTACACGTGTGTGACGTTTGTGGCATTCAGTTAAGTTCGATGTCCTCCCTTAAGGAACATTTAATCACTCATGATGTAAATTATGGTAATGAAAGATCACATGTTTGCGATATAGGAGGTTTAAAAATTCACATGGCTATACATGAGAAAGGTTACAGGGAGGCACGTAACTATAAGTGTAATAAATGCGGAAAAACATTTCTACAACAAGTATATTTAAGGCATCATTATAATAACGAGCACACCAAAGAAAGGCGGACGTTTATTTGTGACCTGTGCGGTAAAACCTTGTCGTCGAATACAAGTCTTCAAGAACATTTGCGAATGCACAAAGGTGTGAAAAGTGTTAAATGTGAACACTGCGGCAAATGTTTTGCTAGAAAGAATACGTTAACTTTACATATGCAAACTCACACAGGTGCTCGTCCGTATAAGTGTAACCAATGTAACAAAACTTTTACGCAACGTAGTACGTTAGTAATACATATGCGATATCATACCGGTGAGAAACCTTATTCGTGTGAAATATGCCATGAAGATTTTGTTAGTAAAAATGCACTAAGTActcattataaaaataaacataatatgttAAAGGTTGTTCAAATACTAGAATTGCAACAAGAAGACTtggctttattaaattttaatatagaacGCTTATGTGAATGTCAAATATGCGGGAAGAAATTTCTTCACaataattatctaaaaaaacATATGGTAACTCACAGTAACGAAAAACCATTCCTTTGCGATCTTTGTCCGAAAACcttcaaaagaaaatacgaACTTACACTTCACATTAAGTGCCATGATAATGTTAAACGATTTCAGTGTGATGTATGTCAGCGAAAATTGAAAACCGAAAAACAGTTACAATTTCATAAgaaccgccatttaaaaaaatacacgtTGTACTGTCCGTTATGTACAAagggattttataaaaaacaagaaatgaaGTGGCATATACAGAAATTGCACGAAAATATTGTGTATGCCTGTAACGTATGTCAGAAACCGATTAAAGATAAAGCGTATCTCAAGCGACATTTGGAAATACATGAAAACAATCacttaaacagtaaaaagtataaGTGTGAGATTTGTGATAAAGCTTACCACTTTAAAACCGCCTTAACACGACATTTGAAGGAACACACCGGAGAAAAAGCACAATTTATTTGTGATATCTGTGGAAAGGCTTTGTCGTCCAAAACGAGTTTGAGCGAACATTTAATCGTACATCAAGGTTTAAAACCTATAATGTGCCAAATATGTAATAAAGGTTTCGCTAAGAATAATAGTTTAAGAGTACATATGCGATTACATACTGGGGTTAAACCGTATCGCTGCGATGTTTGTAAGAAATCCTTCTCACAAAGGTCTACTTTGGTTATTCATTTACGAAAGCATACCGGTGAAAGACCGTATGCTTGTCATGCTTGTAAAGGTTGTTTCATTAGCAAGAATGCGCTTGTTGTACATCAAAAGAATGATCATAAAGTGTTATAA
Protein Sequence
MLRKGDFSCAVCDKTCETKRELWDHEKIHGKKNFECNICGKIIINKFKLILHKKRHAKSYSFTCSECGKGYYSAMNLQVHSEVAHKGVRYSCERCGKIFKDRNYFHVHLRNHDGLSQDRQQQKKGAKEKRKHVCHKCGKQISSAFALKVHLNVHGGRKPYECVTCGKCFASPSAYNVHHRQHTGARPYTCKLCNKSFTIKHSLVVHIRAHVGEKPYICEICQKGFASRSRLNKHVLTHGSFLGSEEKVKPHVCAYCYKSCLYHENNLYTPNFDPITTAQTEALNVGAKYLLTLADSKPSSNLSDVNLLESAEDQLNDTDRELLNLLAAEEDCSDILQNIASNENFENLINEGTSFGQETVIEDFTSTIKNVTAEVSKEEISYGVTVKQKKVGKFKCDQCDKLCTTKKLLKYHLMTHFGIRQHSCEICGKTFKLKYEVTIHKLTHGKPMFQCDICSKMFVHKSHLTCHRRRHTGDYVVYCNDCGKGFVTQSSYRNHVNTQHNKLLHVCDVCGIQLSSMSSLKEHLITHDVNYGNERSHVCDIGGLKIHMAIHEKGYREARNYKCNKCGKTFLQQVYLRHHYNNEHTKERRTFICDLCGKTLSSNTSLQEHLRMHKGVKSVKCEHCGKCFARKNTLTLHMQTHTGARPYKCNQCNKTFTQRSTLVIHMRYHTGEKPYSCEICHEDFVSKNALSTHYKNKHNMLKVVQILELQQEDLALLNFNIERLCECQICGKKFLHNNYLKKHMVTHSNEKPFLCDLCPKTFKRKYELTLHIKCHDNVKRFQCDVCQRKLKTEKQLQFHKNRHLKKYTLYCPLCTKGFYKKQEMKWHIQKLHENIVYACNVCQKPIKDKAYLKRHLEIHENNHLNSKKYKCEICDKAYHFKTALTRHLKEHTGEKAQFICDICGKALSSKTSLSEHLIVHQGLKPIMCQICNKGFAKNNSLRVHMRLHTGVKPYRCDVCKKSFSQRSTLVIHLRKHTGERPYACHACKGCFISKNALVVHQKNDHKVL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-