Basic Information

Insect: Melangyna quadrimaculata
Gene Symbol: L
Assembly: GCA_949320155.1
Location: OX439483.1:70051688-70067830[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 16 6.5e-06 0.0017 20.8 1.7 1 23 221 243 221 243 0.98

2 16 0.54 1.4e+02 5.3 5.8 1 23 249 271 249 271 0.98

3 16 2.8e-07 7.3e-05 25.1 3.1 1 23 277 299 277 299 0.99

4 16 1.3e-05 0.0034 19.8 0.3 1 23 305 327 305 327 0.98

5 16 3.2 8.3e+02 2.9 0.4 2 23 390 413 389 413 0.86

6 16 0.0044 1.1 11.9 0.4 2 23 432 454 431 454 0.97

7 16 0.024 6.2 9.6 1.4 1 23 536 558 536 558 0.97

8 16 0.00049 0.13 14.9 1.1 2 23 566 587 565 587 0.95

9 16 0.0002 0.052 16.1 1.0 1 23 595 620 595 620 0.88

10 16 0.0017 0.44 13.2 2.9 1 23 712 734 712 735 0.96

11 16 0.0012 0.32 13.6 4.6 2 23 923 945 922 945 0.96

12 16 0.14 37 7.1 0.1 1 23 951 973 951 973 0.92

13 16 4.4 1.2e+03 2.4 0.3 2 23 981 1002 981 1002 0.92

14 16 8.2 2.1e+03 1.6 0.3 2 23 1092 1113 1092 1113 0.92

15 16 0.01 2.7 10.7 0.0 1 23 1123 1145 1123 1145 0.96

16 16 2.7 7e+02 3.1 1.3 1 23 1152 1174 1152 1174 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	16	6.5e-06	0.0017	20.8	1.7	1	23	221	243	221	243	0.98
2	16	0.54	1.4e+02	5.3	5.8	1	23	249	271	249	271	0.98
3	16	2.8e-07	7.3e-05	25.1	3.1	1	23	277	299	277	299	0.99
4	16	1.3e-05	0.0034	19.8	0.3	1	23	305	327	305	327	0.98
5	16	3.2	8.3e+02	2.9	0.4	2	23	390	413	389	413	0.86
6	16	0.0044	1.1	11.9	0.4	2	23	432	454	431	454	0.97
7	16	0.024	6.2	9.6	1.4	1	23	536	558	536	558	0.97
8	16	0.00049	0.13	14.9	1.1	2	23	566	587	565	587	0.95
9	16	0.0002	0.052	16.1	1.0	1	23	595	620	595	620	0.88
10	16	0.0017	0.44	13.2	2.9	1	23	712	734	712	735	0.96
11	16	0.0012	0.32	13.6	4.6	2	23	923	945	922	945	0.96
12	16	0.14	37	7.1	0.1	1	23	951	973	951	973	0.92
13	16	4.4	1.2e+03	2.4	0.3	2	23	981	1002	981	1002	0.92
14	16	8.2	2.1e+03	1.6	0.3	2	23	1092	1113	1092	1113	0.92
15	16	0.01	2.7	10.7	0.0	1	23	1123	1145	1123	1145	0.96
16	16	2.7	7e+02	3.1	1.3	1	23	1152	1174	1152	1174	0.92

Sequence Information

Coding Sequence: ATGCATCCAATTAAGAAAGTGATTTATGCGGTTGTTCCGACGGGAACAACACACATCAAAAATCATCTGTACTCGACACACACCTCGTCCAGCTACTCGCCCTCCATGTCGGACGGGACAATTACTCCAAACTCGCTCCATCAccatcatcttcatcatcaccatcatcatcatcagcagcagcagcagaggcTGCATCACCACTTGCAGCAGCAATACCAATGTGAACAGCAACAGAACAGCGGCGGTCACAACCGCGACAGGCATCACAATCGACGTGTTTCAGCCTTAAATGGAGCAACTGCTACTGCTGGTGTGACTGGCGGTGAGGACGACGTTGAGAATGACGACGATGACGAGGCTGGAGACGGGGATGCAGATGAAGATGACGACGCCGCAAATTCTAGCGAGGAAAGGGTTTTCCTTACATCAAACGGTGGTGGTGCCAATGATGCTGTTGGAACAAACACCACAACCACCACTTCCACCACCTCGAACAGCATCAGTGGCGCAACCAGCGGCGGCGGTGTTGGCGGTGGCAGTGACAAACATTCCGTGAAAATACCAACGAAATTGCGGAAAATCGATAGGGATTCGGCAAAGTTGTTGGATAAGTTGACAAGTGATGGCATTAAGAGCGCGACCGACCGCGATGGATCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGCCTTGGGTATCTCAAGAAGCATGAACAGagtcaTGCCGAGCACCTACCATTCAAATGCGACTACTGTGCGAGACTTTTCAAACACAAACGGTCTCGTGACCGACACACCAAGTTGCATACTGGAGATAGACGATACAGGTGTCCACATTGTGAGGCGGCATTTTCAAGAAGtgATCATCTGAAGATCCACATGAAAACTCACGACAATCAAAAGCCATTTCAATGCACCATCTGCAATCGCGGCTACAACACAGCAGCTGCATTAACATCGCACATGCAAAATCACAAGAAACAAGCTGCAATCCTAGCTGCTGGTGGCAATCCGGCTGCACTCAATTACAGCCCCCGTTCAACTGGTTCCGGTTCAAGTAATGGCAGTCTACAAAAACGTCGCTACACATCTATTGCAAACACTAAAAGTCCAAGTCCGAGTTCATTGGAATATGCTAAGCGTATGCGCAGCTCTTTTATCACATGCATGTACTGTACAAAATCCGACTTCACATCAATGGAGCAGCTAAGCAGTCATATTCAAGCAATGCACGAGAAGGAAGCTCTGGCCAATCAATCGTCATCGGTGGCAAGTGGCTTTCAAATGTCATGTGAGTACTGCACAATGAAGTTTCCCAGTGTTCCGGCAATGTTTCAGCACATGCGAACTACACATATTGATCGTCTATCAAGCCCGAGTAGCTATTTTGAGCATTTTAATCGATTAGCTGCCACGGGGACTTTTAGTCCACGATTGCCAACTCCCAAGTCGACGAATGAAACAAAAGTCAAAGTTGAAGAACCCAGTCCTAAGGCTGAAGAAAAAACCGATGACGAACCAACTGATTTGAGTCAAAACAGGCGATCCATTCAGACTCCGTCGCATGAATCGGCCGAAGCTGGCGACCGGCCAGGTGTGTTCTTCTGCAATCAATGCAACGATGGTTTTCCCGATTTCGATAGTTTCCGCAATCACCTGAAGTCACACATTGTCCAAGGCCTCAGTCTGGTGTGTCACCATTGTGGCCAGACCCTGCGAGATCAACCAGAGTACGAAAGGCACATTGTTTCCCATTTTCTCATCACTTGCTCCGAATTCGCTTGCACAGAAAAGAACTGCAATAAGACCTTCTCCAAGCCGGACGAGCTGCAGAAGCACCTCTTCGACAATCACATTCAGACGTTGTTCAAATGTCTTCTGTGTTCGGATCTTTTCGAAACAAAAGTTGCGGTACAAGTTCACTTCGCTTGCATCCATTCCCCGGAGAAGAAGATTTTCCGCTGTTCAGCCTGCATGGACACCTTCCATGGAGAACAAGAGTTTCATATTCATGTGAAAACTCGCCACCAGACGATAGTTGGATCACCAATTCAATGCATGTTCTGCCGTGCTGTTTGTTCCACCGAACTCGAAATGCACTTCCATCTAGCGGCCCATGCCCGCCAGTTCCGTTGTCCGTCGTGCCCAGAGACTTTCCATGTCGAATTCCTACTCGATCGGCATATGCAAACTCATCATCACGGACAGAAAGAGGTTGAATCCATACCTTCTCCTGTCAATCCATCACCAGTGAACACGATCAATCCGCTTTATATGAGTGCTCTCTTCAACAAGCCTCCTTCATCAactcaaaacaacaacaacagcatccTGGACTACAATAATTTCGCAATGGGCAAGAATCTCTTCGGAAATGCCTCTGGGAACAAATTCTACAATCCTCTGCAAGTCGATACGGGATCGGCTATGAAACACCCATCGCTTGTTTACGCCAGCTTGAATCAACGCTACTTTGACACCAATCGAACTATTCTCGAAATGTACAATCAACATCAGCAGGATAAGCTTGGTGCTGGCCCCGTTGCCAGTATGTTCACCAGCCCcagcaacaataacaacaacaaccacaacagaAACATTCCAAAACCTCCGCAAGAATCCAACAAACCATCAGACAGAGCTATTCATTCCGGAGGCGGCTTCAGCTGCGGGATGTGTGAACGTAACGATTTCCGCACCGAAGCCGAAATTCACTCACATCGCAAGATCGTCCATAATCTCAAGACCGGGGTGAGTCTTCGTTGTGCTTATTGCAGTGGAAACTTTAAATCACGCAGTGAGCTGGAACACCACATGAAGACGTGTCACAATTCAACTGGCAAGCATAAATGTTTGATCTGCGATGAAATCTTCCCCTCGCCCGCAATACTCGCCGAGCATAAGTTGCAACACTCAAAGGTCGGGCAGTCTGGAAAGTGTTCCCACTGCGCCAAGGCTTTACCCGATGTCATGGCTTTCAAGGGACACCTTTTGGACCACAACACCGAGGGCCAGATGCCAGTTCAATGCATTTGCTGCCGCCAAACACTTCATTCAGATTTTGAAATTGGTCTTCATGCTAAATTCCACACTAAGTCATCGTCTGTTTCGGAGAGCGTTTGTGCCCTGTGCTTGGAAACAATACCCAACACAATCGATGCCAAGGTCTGCGATAAGTGCTGTCGCAAGCATAACCTCAACAACAAGTACTCCAACCAGCGAAGCAGCTTCGACAGCAAATCGGGACAGTCAAACTATGTGGAGAACCGTTGTAATCTCTGTAATGTCATCATGCCCCACGCCCAGAAACTCCAGGAACACTTGGTCGAGCACACGTTCGCCGGCTGCGAAGATAGAGGTTTCTCGTGCTACATCTGTTCGGCAGTCTTTACAGCTCCCGCTGGCTTGCTTACTCACATGACCGAGCACGGAGCCAATTCCCGACCCTACGACTGCAACCTATGCACTGACAAGTTCTATTTCCGCGCTGAATTGGACCACCATTTGGTCGATCACGAAACTCGAGATCGATCAAAGACCTCCCAACATGCCAGGGATGCAAGTCCTCTAACTGATGAAAACAAACCACCATTCACCGAACCATCACCACCTTCGGCCGCAGTAGTAGAAACTAAAAAGCTTGAGCTTAAAAATGAAGCCCTGGAAGAGAAACCAACTTTAGAAGAAGATGACGATGAATATATCGAAGTTGAGAAAGTTCCCGAAATCATCACATCGCAGGAGAAATCATCACATCCCTCCCATAAGGACGAATAG
Protein Sequence: MHPIKKVIYAVVPTGTTHIKNHLYSTHTSSSYSPSMSDGTITPNSLHHHHLHHHHHHHQQQQQRLHHHLQQQYQCEQQQNSGGHNRDRHHNRRVSALNGATATAGVTGGEDDVENDDDDEAGDGDADEDDDAANSSEERVFLTSNGGGANDAVGTNTTTTTSTTSNSISGATSGGGVGGGSDKHSVKIPTKLRKIDRDSAKLLDKLTSDGIKSATDRDGSYQCQFCDKSFPRLGYLKKHEQSHAEHLPFKCDYCARLFKHKRSRDRHTKLHTGDRRYRCPHCEAAFSRSDHLKIHMKTHDNQKPFQCTICNRGYNTAAALTSHMQNHKKQAAILAAGGNPAALNYSPRSTGSGSSNGSLQKRRYTSIANTKSPSPSSLEYAKRMRSSFITCMYCTKSDFTSMEQLSSHIQAMHEKEALANQSSSVASGFQMSCEYCTMKFPSVPAMFQHMRTTHIDRLSSPSSYFEHFNRLAATGTFSPRLPTPKSTNETKVKVEEPSPKAEEKTDDEPTDLSQNRRSIQTPSHESAEAGDRPGVFFCNQCNDGFPDFDSFRNHLKSHIVQGLSLVCHHCGQTLRDQPEYERHIVSHFLITCSEFACTEKNCNKTFSKPDELQKHLFDNHIQTLFKCLLCSDLFETKVAVQVHFACIHSPEKKIFRCSACMDTFHGEQEFHIHVKTRHQTIVGSPIQCMFCRAVCSTELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQTHHHGQKEVESIPSPVNPSPVNTINPLYMSALFNKPPSSTQNNNNSILDYNNFAMGKNLFGNASGNKFYNPLQVDTGSAMKHPSLVYASLNQRYFDTNRTILEMYNQHQQDKLGAGPVASMFTSPSNNNNNNHNRNIPKPPQESNKPSDRAIHSGGGFSCGMCERNDFRTEAEIHSHRKIVHNLKTGVSLRCAYCSGNFKSRSELEHHMKTCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCSHCAKALPDVMAFKGHLLDHNTEGQMPVQCICCRQTLHSDFEIGLHAKFHTKSSSVSESVCALCLETIPNTIDAKVCDKCCRKHNLNNKYSNQRSSFDSKSGQSNYVENRCNLCNVIMPHAQKLQEHLVEHTFAGCEDRGFSCYICSAVFTAPAGLLTHMTEHGANSRPYDCNLCTDKFYFRAELDHHLVDHETRDRSKTSQHARDASPLTDENKPPFTEPSPPSAAVVETKKLELKNEALEEKPTLEEDDDEYIEVEKVPEIITSQEKSSHPSHKDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01542500;
90% Identity: iTF_00427670;
80% Identity: -