Basic Information

Gene Symbol
-
Assembly
GCA_002803265.2
Location
NW:454942-462890[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 8.2e-05 0.006 16.4 6.6 1 23 94 117 94 117 0.97
2 19 3.5 2.5e+02 1.8 3.5 1 23 121 142 121 142 0.95
3 19 0.0083 0.6 10.1 4.2 1 23 171 193 171 193 0.98
4 19 2 1.4e+02 2.6 0.3 2 23 199 220 198 220 0.86
5 19 1.9 1.4e+02 2.7 2.8 1 20 225 244 225 246 0.88
6 19 0.017 1.2 9.1 0.6 2 21 261 280 260 285 0.92
7 19 0.0011 0.079 12.9 1.0 1 23 286 308 286 308 0.98
8 19 6.9 5e+02 0.9 1.3 2 23 523 545 522 545 0.79
9 19 0.001 0.074 13.0 1.0 1 23 551 573 547 573 0.89
10 19 0.00019 0.013 15.3 0.1 1 23 642 664 642 664 0.96
11 19 0.068 4.9 7.2 6.4 1 23 670 692 670 692 0.97
12 19 0.00011 0.0078 16.0 0.2 2 23 723 744 722 744 0.96
13 19 0.00018 0.013 15.3 3.5 1 23 750 772 750 772 0.98
14 19 0.0032 0.23 11.4 2.2 1 23 827 849 827 849 0.96
15 19 0.00095 0.069 13.1 1.4 1 23 855 877 855 877 0.97
16 19 0.00018 0.013 15.3 0.7 2 20 913 931 912 933 0.94
17 19 1.6e-05 0.0011 18.7 1.9 2 23 964 986 963 986 0.96
18 19 3e-05 0.0022 17.8 1.4 2 23 1026 1048 1025 1048 0.96
19 19 0.04 2.9 7.9 2.4 2 23 1056 1078 1055 1078 0.95

Sequence Information

Coding Sequence
ATGACTCCAATGAAAGATAACATGAAGGTTAAAGTCACTGGTGCTGTTGATGCTGTTACCAGGACTACAGTTGAAGATAATCATGTGTCtttgataattgaaaatactgAGAATGTTATAAAGATTGAAACTGATATATTCAATGATTATGTGTGGAATAGTACTATCGAAATTTCTAAAGATGTTGCCAACGATAATAATGTGAAGTTACCTTTGGAATCTCAgGGTGTCccagttaataatattgacttaAATCCTAaagatacaaattataaattattctactgCAAATATTGTGGAAAACAGTTTAAGTTCAGATTTGGTTTGAATAaacatattcaaaaatgtcataatcACACGCATGAATGCAAATTTTGTAAACTTACTATTGATAAGagtaaatataatgaacatGTTAAAAACCATGAAAAAGATGAAACTAGGATTGATATTACTCCTAATATAAAATCGCGCAAATTAAATGATGTTTGGAAAAgtgaaataaatgaatttaagtgtaatatttgttttcaaaaatgtcataGTGAAAAGAATTTAGTGGAACATATGGAAATTCATGACAACGATTCAATACAGTGTAATGATTGCTTaaagtatgtattaatttctaaattaaataatcatatgcaAGAATtgcataataaacatttttttaaatgtaagaaATGTAACTTACtatttgaaaaagaaaaatacttaaactgTCATTTAATGCTTTGCTTAAAAAGCTCTTATACCAAATTCAAGCCTAATTCAACGACTTGTTCTGCTTGTGGAATTgcttttaatagttatttatcattgaagAATCATATGACTATTGGTTGTGAGCattatacttgtaaatattGTGAACAGTTTTTTAATTCAAGGATTTTATGGTTAAGACATGTGAGTGTTCATGAAAAAGATGAACAATACGTAATGTTAACagtaaataacgataaaacaACTACAACTAGAGAACATAATCAAACTGAGGTTGTAAATGATTCTTCtttcaatacaaataaagGACAGTTATTATCTACCAATGTTACAGGAAGAAATAGCTTAGATCAAACTGATTTAGTCAGCAGCAATACAACAATTGTATCAACtgtttcaaataattcaataacaaataGTTGTGTTGTTTTGAATagtaatcaagaaaaaaacttGTGTATAATTAACAGAGAAACAAATAGTTCAGatcaaatgaatttaaaaaacaataatgaatcAATAATTTCGACTGTTTCACATAACTCAATAGTGAACAATTGccatatgttaaatattaaagaagaaaaaagcATAAGTACAAATGTCAGAGAAAGAAACAGTTTTGATCAAATGGATTTAGTGAATAGCGATGAACCAACTATAGCAAACAAACCTCTTGATTTAATGGCAAGCCCAAACCCTACTAGTATAGATAGTAATAGTGTTGCATCTATAGTTAGGGAAACACTTTACttctgtattaaaaaattgcctaatattaaaaatgtatcttgcAATGACAATTATGAACAGACATCGCACgtcaatgttatatttttatgtagaatttgtaaaaaatctccattttcaaatatacatttgtttgCATTGCATATGAGTGATCACCGTGAATGTAACATGCATGAATGTATTGTGTgtgataaaacatttaaaactgtatCTCTTTGGGTAAACCATATGATTGTTCATCAACAGcaattagatttaaatgtatcaaCAGTTCAGTGTTCTCCTATAAAAACTGAACCTCATACATTAGGCTCAatcaaagttgaaaatatgGAGTCTCAAATTTGTACAACttcaaaaaatagaaaatttatatctTCATCGCATGGTTCATATTCAGATAAAACAAGCTTGAATAAtagtgacaaaaaaaaaatatatcgatatGACTGtagtatatgtaaaaaattatttccttCAAAGGTTGCATTAGAAGCTCATCAAACACTTCATAATAAACCACAGTCATTTTCTTGTAAGTAttgtaaaagaatattttctaaaaaggCTTATTGTACAAATCATGAAAAATCtcacattaaaaatgaatataaaaacaaattatcagCTCCTACAGATATCgatttgaataattgtattaatttaagaaataagaagAAATGTACAGTTTGCACCAtttgtaataaacaatttgcAAGTGTTGGTTCCTTAAGCAATCACATGTATATTCATTTAGATCATAAATCATACGAATGTCaatattgtaacaaaaaatatattaagaaagCTTATTACATGAAACATGTGAAAAAACATGTATTCCAAAATGGAATTTTAAGTGCTTCCAaactagaaataaataatacaacagtTGAAGATAATGAAGTAccaaaaatcgaaaattgtGATGATTTTGAGTTAGTTCATAATCCAGTTGAtggatatttaaatgatacaaatttaactaacataaaattgtttacttgTGATGTATGTGAGGAAAAATTCTCTTGTCCATCTCAATTGAATCAACACCGAACGTTACATTCTGGTATTGTACCATATGTATGCAAAATTTGTAATAGATCTTTCCCCTTCAAATTCCGAtggaatttacatttaaaagaacattataaaaataatattaaaaatttacaaaataaacttcATACTAATAACCAAAACTCAAATATTGGTAAACAAAAGATTGAATCTTTTCATAATCAAGATACGATGAAAtgtcaatattgtaaaaaagaatttaactCAATATCTCAGTTGAAAAATCATTTAGGAAGGACCGAGGAATGTCGTCgccattgtaaaattaactttCCAGAACTTCCATCAAATCAAGCTTCAGAGAATTTTACCAAATCTTGTCGATCTCAATGCAATATTTGTAAGAAAACATTTAGTACCTCTTACAATCGATTTGTACATTTAAGAAatgttcacaaaatattagatacaaCAGTTTTGAATATTGATAATCATACCAGTTTTCAAAAAGACAAAGTGATGGAAATAGTTCAGAACCCAGTGACTAAGGAACAAAATAGAGATGAtcgtaaaaaatgtaagttttgtgataaattatacagtaatAAAGGTAATTTAAGTCGCCACATATCTATGGTTCACACAAACCGTTATGAACAAATAACCTGTCATATTTGTctaatgacatttaaaaacaaattttcatatataccacatttaaaaatgaaacacaACGACTATTTCAAAATGATgaattaa
Protein Sequence
MTPMKDNMKVKVTGAVDAVTRTTVEDNHVSLIIENTENVIKIETDIFNDYVWNSTIEISKDVANDNNVKLPLESQGVPVNNIDLNPKDTNYKLFYCKYCGKQFKFRFGLNKHIQKCHNHTHECKFCKLTIDKSKYNEHVKNHEKDETRIDITPNIKSRKLNDVWKSEINEFKCNICFQKCHSEKNLVEHMEIHDNDSIQCNDCLKYVLISKLNNHMQELHNKHFFKCKKCNLLFEKEKYLNCHLMLCLKSSYTKFKPNSTTCSACGIAFNSYLSLKNHMTIGCEHYTCKYCEQFFNSRILWLRHVSVHEKDEQYVMLTVNNDKTTTTREHNQTEVVNDSSFNTNKGQLLSTNVTGRNSLDQTDLVSSNTTIVSTVSNNSITNSCVVLNSNQEKNLCIINRETNSSDQMNLKNNNESIISTVSHNSIVNNCHMLNIKEEKSISTNVRERNSFDQMDLVNSDEPTIANKPLDLMASPNPTSIDSNSVASIVRETLYFCIKKLPNIKNVSCNDNYEQTSHVNVIFLCRICKKSPFSNIHLFALHMSDHRECNMHECIVCDKTFKTVSLWVNHMIVHQQQLDLNVSTVQCSPIKTEPHTLGSIKVENMESQICTTSKNRKFISSSHGSYSDKTSLNNSDKKKIYRYDCSICKKLFPSKVALEAHQTLHNKPQSFSCKYCKRIFSKKAYCTNHEKSHIKNEYKNKLSAPTDIDLNNCINLRNKKKCTVCTICNKQFASVGSLSNHMYIHLDHKSYECQYCNKKYIKKAYYMKHVKKHVFQNGILSASKLEINNTTVEDNEVPKIENCDDFELVHNPVDGYLNDTNLTNIKLFTCDVCEEKFSCPSQLNQHRTLHSGIVPYVCKICNRSFPFKFRWNLHLKEHYKNNIKNLQNKLHTNNQNSNIGKQKIESFHNQDTMKCQYCKKEFNSISQLKNHLGRTEECRRHCKINFPELPSNQASENFTKSCRSQCNICKKTFSTSYNRFVHLRNVHKILDTTVLNIDNHTSFQKDKVMEIVQNPVTKEQNRDDRKKCKFCDKLYSNKGNLSRHISMVHTNRYEQITCHICLMTFKNKFSYIPHLKMKHNDYFKMMN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-