Basic Information

Gene Symbol
L
Assembly
GCA_963662105.1
Location
OY759211.1:90031959-90041732[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 7.3e-06 0.0007 20.7 1.7 1 23 222 244 222 244 0.98
2 19 0.61 58 5.2 5.8 1 23 250 272 250 272 0.98
3 19 2.4e-07 2.3e-05 25.4 3.2 1 23 278 300 278 300 0.99
4 19 1.5e-05 0.0014 19.8 0.3 1 23 306 328 306 328 0.98
5 19 0.25 24 6.4 0.5 3 23 391 413 389 413 0.87
6 19 0.008 0.76 11.2 1.9 2 23 438 460 437 460 0.96
7 19 0.086 8.3 7.9 0.7 1 23 552 574 552 574 0.97
8 19 0.0019 0.19 13.1 0.9 2 23 582 603 581 603 0.96
9 19 0.0059 0.56 11.6 0.3 1 23 611 635 611 635 0.91
10 19 2.4 2.3e+02 3.3 0.0 1 19 640 658 640 660 0.93
11 19 0.29 28 6.2 0.4 2 23 671 693 670 693 0.94
12 19 0.028 2.6 9.5 2.6 1 23 732 754 732 755 0.96
13 19 8 7.7e+02 1.7 0.9 1 23 933 957 933 957 0.86
14 19 0.0014 0.13 13.5 4.6 2 23 966 988 965 988 0.96
15 19 0.16 15 7.0 0.1 1 23 994 1016 994 1016 0.92
16 19 5.8 5.6e+02 2.1 0.6 2 23 1024 1045 1024 1045 0.92
17 19 0.62 60 5.2 0.5 2 23 1139 1160 1139 1160 0.94
18 19 0.0052 0.5 11.7 0.0 1 23 1170 1192 1170 1192 0.97
19 19 2.3 2.2e+02 3.4 1.3 1 23 1199 1221 1199 1221 0.93

Sequence Information

Coding Sequence
ATGATGGCTTTGAAGATGCTGTATCGTGGACCCAGTTCGAGATTAGAGAatcttattgaaaaaattcaagcCACTAAGGAGGTGGTCGGCAcggATATCTACTCCACCCACACATCATCGAGTTACTCACCCTCCATATCGGATGGCACCATGACGCCCAATTCAATGCATTTGCTCCATCATCAACATCATATGCAACATCCACATGCACAACTACCACATTTGCCAACACAACAGCACGTGGATGAAGAAGGTGCACGAACGCGCAGGCAACGAGGTAACACTGATGCCGTTCAGAATAACGGTAACGGTAATGTGCCTGTTGCGGACCGAAGTAACGAAGCAGACGAAGATGATGCTGAAAACTCTAATACTGTTGAAGATGTTGATGttgacaaaaaacaaagtgaGGTGTCGTCATGCCTTAATGGTAAAAACAATCCAAGTGATAATTTGGTCGAACAaaggcaacagcaacaacactcACAACAACACCATCATCGTTATCGTCAGGGACGTTGTCGTACGACGGGCTTGGATGGGCATACCATAAAGTTACCAAATAAATTGCGTAAAACAGATAGGGATGCTGCCGCGGCAAGCGGAGCAGGAAAATTTGATAAGCTGACAAGTGATGGCATTAAAAGTGCAGCCGACGGATCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCACGACtgggttatttaaaaaaacatgaacAGAGCCATGCCGAACATCTGCCCTTTAAATGTGACTACTGTGCTCGATTGTTCAAACATAAACGTTCGCGTGATCGGCATACTAAATTGCATACAGGTGATAGACGCTATAAATGTCCACATTGTGAAGCTGCATTTTCAAGAAGCGATCACTTGAAGATTCACATGAAAACGCACGATAACCAGAAGCCTTTTCAGTGTACCATTTGCAATCGTGGTTACAATACTGCCGCTGCTTTAACTTCGCACATGCAAAATCATAAGAAACAAGCTGCCATTATTGCTGCTGGTGGCAACCCACAGGCACTCAACTATAGCCCTCGTTCAACTGGCTCTGCTTCGAGCAATGGAAGTTTGCATAAGCGTCGCTACGCAATGAACGCAGCCTCCGATAGCAGTCCAAGTCGCTTGGAATACCCAAAACGTTTGCGCAGTAATTTTCTCAACTGCACGTATTGCACCAAAAATGACTTTACCTCATTAGATCAGTTGAATGCGCACGTACAATCGATGCATGAAAAGGAGCTGGCACCGCCCGCACCAGCTCAGACTCCCACCAATGTAACAGATCTTCAGACTTTTCAACTTAACTGTGAGTACTGCACCATGAAGTTTCCCAATATTCCAACCATGTTTCATCATATGCGTACAACACACATCGATCGTTTGACTAGCCCTAATTCTTATTTCGAACACTTTAATCGCTTGGCTGCTTCGGGTACATTCAGTCCACGTTTGATTGCAACTGCAAAAACAATGCAACGCACTGAAGAGAGTAACATTAAGCTGGAGCAAAATTTGAGTCCTAAGAGTTGTCAAGAAACAAAACAGGAGGAACCCACTGATCTGAGCCAGAACAAACGACGTTCTGTGACACCAATTTCACCGCAACATAGCTCACCTAGAACTCCCGAGAAGCCACCAGGtgtgtttttttgtaatcaGTGTAATGCAGGCTTACCGGACTTTGAGAGTTTTCGCAATCATCTCAAATCACATATAGCACAAGGCTTAAATCTCGTCTGTCATCATTGTGGCTTAGCGTTGCGTGAGCAATCAGAATACGAACGGCATGTAATTTCGCATTTCCTCATTACGAATTCAGAGTTCAACTGTGCCAGTAATTGCAACAAGTCCTATGGAAAACCCGAAGAATTGCAAAAGCATTTGCTTGATACTCACGTAATCACCATGTACAAGTGCGCCCTTTGTTCAGAGCTATTTGAAACTAAGGTCGCTATACAAGTGCATTTTGCCTGTGCACATTCACAGGAGACAAAAATACTGCGTTGCTCCGCATGCATGGAAGTCTTTCGCAACGAACAGGACTTCAACGTGCATGTTAAGATGCGTCATCAAACAGTTAATGGTTCCTCAAGCAACAACACTTCACTTCAGTGCATGTTTTGTCGCACGGTTTGCTCATCAGATCTTGAAATGCATTTTCATCTTGCCGCACATGCGCGGCAATATCGTTGTCCTTCTTGCGCTGAAACTTTTCATGTCGAATTTTTACTGGATCGTCATATGCAAAGTCATCATGGCGGCAACGAGCGTTCACCAATGTTGCCAACGTCTAATAAGGACAATAACTTCGAAGAGCATTCACCTATTGCTGTCGCTGTcgtcaacaataacaacaaccaaATGAGTCCAATGAATTCGCTTTATGTTAATGCACTTTTCGGCAAATCACCGCTCATGCCGCTTGCTGCTcagcaaaataacaataacagtaTTTTAGACTATAACGTTGCTTTTGCAGCGGCACATCTCAACAAGGGTCTTTTTCCAGCTGCCGCCGCTGCTGCAGCATCAGCTGGCAAATTCTACAGTCCATTGCAGGTGGATACTGGTGCTATGAAACATCCAGCACTGATGTATGGTTTGGGTCAACGCTACTTTGATACCAATCGCACGCTCATTGATATGTACAATCAACATCAACAGGATAAAGTAACCATACCCTCCGGTGGTAGCTACTTTGTCAGTCCAAAAATGTCAACGAACTCAGCTCAAGAAGCTGCAGTTAACTCCTGTAAAACTTCCGCCGAACAGCATGTGATGTCAGGATTTAGCTGCGGTATGTGTGAACGTAATGACTTTCGTACCGATGCCGAATTGCATTCACACCGAAAAATCGTACACAACATAAAGACTGGCGTTAGTCTGCGCTGTGCCTACTGTTCGGGTAACTTCAAGTCACGTAGTGAATTGGAGCATCACATGAAGACTTGTCATAACTCTACTGGCAAGCATAAGTGTCTCATTTGTGACGAGATATTCCCATCGCCTGCTATATTGGCGGAACACAAATTGCAGCACTCAAAGGTGGGACAATCTGGAAAGTGTTCCCATTGTGCCAAACCGCTAAATGATGTTCAAGCATATAAAGGTCACTTGACGGAGCACAACACAGAAGGACAAATGCCAGTACAATGTATTTGTTGTCGCCAATCCTTGCACTCAGATTTCGAGATAAGTCTTCATGCAAAATTCCACACCAAATCATCTAATATACCTGAGACTGTCTGTGCGCTCTGTCTAGAACCGATACCAAATGCTACAAATGAGGCTAAAGTCTGCGAAAAGTGTTGTcgaaaacataatttaaataataaatttaataagcaACGCGAAAACTATGAGTCCCGTCCTTTGCCAAGTGAACCGCGACATTTTATCGAAAATCGTTGTAATCTCTGTAAGATGATACTGCCACATCCacaaaaattacaggaacatcTGGTTGAACATACATTTGCTGGCTGTGAAGATAGAGGCTTCATTTGCTATATTTGCTCTGCTGTTTTCACAGCGCCCGCAGGGCTGCTGAACCACATGAATGAGCATGGACAGAATGCACGTCCGTACGACTGTAATTTATGTACGGATAAATTTTATTTCCGCGCTGAATTGGACCATCATTTAGTAGAACATGAGCTGAGAGAAAACATTGTAAAAGAGCTAACAGCAACGCAAGTGCCAGATATCAAGGAGCAATCAAGAGCAGCACGCACTGAGCCACAAGAAAATAATAGCAACGTTATGCTAGCCGGTCTGTCTGCCGAGgttaaaaaggaaattttcgaGGAGCAATGCAAAAACCAAATGGGCGCCGAAGAGGAAGATGAATACATTGAAGTCGAAAAAGTACCAGAACGGGCTGAGACCGTTGCAGTAGTAGAGAATGAAAATCATCTCTCTGATGAAACAAATTGA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATKEVVGTDIYSTHTSSSYSPSISDGTMTPNSMHLLHHQHHMQHPHAQLPHLPTQQHVDEEGARTRRQRGNTDAVQNNGNGNVPVADRSNEADEDDAENSNTVEDVDVDKKQSEVSSCLNGKNNPSDNLVEQRQQQQHSQQHHHRYRQGRCRTTGLDGHTIKLPNKLRKTDRDAAAASGAGKFDKLTSDGIKSAADGSYQCQFCDKSFPRLGYLKKHEQSHAEHLPFKCDYCARLFKHKRSRDRHTKLHTGDRRYKCPHCEAAFSRSDHLKIHMKTHDNQKPFQCTICNRGYNTAAALTSHMQNHKKQAAIIAAGGNPQALNYSPRSTGSASSNGSLHKRRYAMNAASDSSPSRLEYPKRLRSNFLNCTYCTKNDFTSLDQLNAHVQSMHEKELAPPAPAQTPTNVTDLQTFQLNCEYCTMKFPNIPTMFHHMRTTHIDRLTSPNSYFEHFNRLAASGTFSPRLIATAKTMQRTEESNIKLEQNLSPKSCQETKQEEPTDLSQNKRRSVTPISPQHSSPRTPEKPPGVFFCNQCNAGLPDFESFRNHLKSHIAQGLNLVCHHCGLALREQSEYERHVISHFLITNSEFNCASNCNKSYGKPEELQKHLLDTHVITMYKCALCSELFETKVAIQVHFACAHSQETKILRCSACMEVFRNEQDFNVHVKMRHQTVNGSSSNNTSLQCMFCRTVCSSDLEMHFHLAAHARQYRCPSCAETFHVEFLLDRHMQSHHGGNERSPMLPTSNKDNNFEEHSPIAVAVVNNNNNQMSPMNSLYVNALFGKSPLMPLAAQQNNNNSILDYNVAFAAAHLNKGLFPAAAAAAASAGKFYSPLQVDTGAMKHPALMYGLGQRYFDTNRTLIDMYNQHQQDKVTIPSGGSYFVSPKMSTNSAQEAAVNSCKTSAEQHVMSGFSCGMCERNDFRTDAELHSHRKIVHNIKTGVSLRCAYCSGNFKSRSELEHHMKTCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCSHCAKPLNDVQAYKGHLTEHNTEGQMPVQCICCRQSLHSDFEISLHAKFHTKSSNIPETVCALCLEPIPNATNEAKVCEKCCRKHNLNNKFNKQRENYESRPLPSEPRHFIENRCNLCKMILPHPQKLQEHLVEHTFAGCEDRGFICYICSAVFTAPAGLLNHMNEHGQNARPYDCNLCTDKFYFRAELDHHLVEHELRENIVKELTATQVPDIKEQSRAARTEPQENNSNVMLAGLSAEVKKEIFEEQCKNQMGAEEEDEYIEVEKVPERAETVAVVENENHLSDETN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00258263;
90% Identity
iTF_01486632;
80% Identity
-