Basic Information

Insect: Megathymus ursus
Gene Symbol: zfh1
Assembly: GCA_003671415.1
Location: PDGT01000009.1:422180-433505[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0053 0.41 11.6 0.4 1 23 74 96 74 96 0.97

2 8 5.3e-06 0.0004 21.0 3.2 1 23 107 129 107 129 0.98

3 8 1.6e-06 0.00012 22.7 6.2 1 23 138 160 138 160 0.99

4 8 0.00011 0.0084 16.9 1.0 1 21 166 186 166 187 0.95

5 8 0.017 1.3 9.9 0.2 2 19 449 466 448 466 0.97

6 8 8.2e-06 0.00063 20.4 1.1 1 23 771 793 771 793 0.94

7 8 0.0002 0.015 16.1 7.3 1 23 799 821 799 821 0.98

8 8 0.058 4.4 8.3 7.1 1 21 827 847 827 848 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0053	0.41	11.6	0.4	1	23	74	96	74	96	0.97
2	8	5.3e-06	0.0004	21.0	3.2	1	23	107	129	107	129	0.98
3	8	1.6e-06	0.00012	22.7	6.2	1	23	138	160	138	160	0.99
4	8	0.00011	0.0084	16.9	1.0	1	21	166	186	166	187	0.95
5	8	0.017	1.3	9.9	0.2	2	19	449	466	448	466	0.97
6	8	8.2e-06	0.00063	20.4	1.1	1	23	771	793	771	793	0.94
7	8	0.0002	0.015	16.1	7.3	1	23	799	821	799	821	0.98
8	8	0.058	4.4	8.3	7.1	1	21	827	847	827	848	0.96

Sequence Information

Coding Sequence: ATGAAAGTGCTGGGCCCGCTTATGGGAGTCGGCGGGTGGTACGAACGGTTGGCGGCCGGCTGGCTCGCCGACATGCGGAGTAAGCAGGTCCCGACCTCCGCCACTTCGGCCAGGCGGCTCGCGGCCACCATCCGGCCGTTAACGGGCGGAGGTTCCGAAGGCAAACCTTCGGAGGAGGAAGAGGACCGAGGTGGTTCCCCCCTCGGACCCGGCGGCCCTTTCTCCTGTAGTCAGTGCCGCGGCGCATACCCCACGCGCGAGCAACTCGAGCGTCACGAGAAGCTGCACTCCCCCAACACACAGGTGGATAGAGTCAAATATACATGCAAGATTTGTCACAAGAGCTTTATCAACGTGTATCGTCTGCAACGACACATGATCAGCCACGACGAAAGCGCCCGGCTACGAAAGTTTAAATGCAATGATTGTGACAAAGCTTTTAAGTTTAAACATCATCTTAAGGAACATTTGCGTATCCACAGTGGAGAGAAGCCCTTCGAATGTGCCAATTGTGGAAAAAAATTTTCACACTCTGGCTCCTATTCGTCTCATATGACCTCAAAGAAATGTCTTGTGATGAACCTTAAAATGGGAAGAATAAAACCAAACAACCCTGCGCTTAACCCTGATCGAAGTCCTTCGAGAAAGCGATCGAACGCCATGGTTGCCTCACAgatcaataacaatataacaccAAATACCTCCTTTCTGCCTACCTTACCTAAATATAACACGGCAGCATTCTTTGCATGGACGCCAACGCCAGATAATAATTTTCCTCAATCAACGTTGCCGCAGCCAGGATTAAATCCTTTCTACATGCCACCAGGTGTACCAATGAGTCCCACTACTGGCATTGCTCCTTATACCATTCCGGCTTCTATAGGACAATTTTTTGCGCAACTAGCATCCTCGCAATATCCACTTAGAAAAATTGAGAAACCTATAAGCCCAAACCAACATGGTATTCCATTAGGAGACCCTGAAGATCTAATAGAAGAAGTCACTGAAGAGGATGATAAAAGATCGGAAGGAAGCGCTGAGCTTGTTATGGATATTGAAGATGACGCTATATCAGTTAAAAAAGAACAAGATGATCTAGAGGCAGATCCCAGGTCTCCTCAAAACTTTGAGTCCGTCCCTATGAATGACAACGATCATGAAGCTGGTAATAATCATGCAGgctttaaaacaatattggaGACAGTTAGCGCATCGGTAACAAAGCATTTCTTAAGGGCAAATATGGAAAAGCTTTCTCCGGTTTCTGGAAATGTTTGTCCGAGTATAGAATCGTCAGCTGCTCCAcatattgttgtaaaaaataaatatgtggatACAAATCAATGCTTAAAATGCAATGCTACTTTTAGCACTattgatgaattaattaaacatgaTAAATCTGATTGTGAAAACATGTTCAGGAAACATGAAGGGTTGGCAGCACAAGTTGCAGAGACTGTAGCATTAAATAGGTTGGAAGCTGAAATTCGGGCATCTATTCAAAGTGGTGTTAGTGCTAGCGAAGATGAGGATTTTGGAAGAGACGACCGCGAGGATAAAACTTCTTTAAATGACTCTGACAGAAAGATCCGAGTCCGTACTGCGCTAAGTGAGGAGCAACAGGTAATACTAAAGGAGCATTACACTATTAATCCAAGGCCGAATAGAGAAGAATTTAAGAAAATCGCTCAGCAAATTGGACTTGATAGTAGAGTTGTACAAGTTTGGTTCCAAAATAACAGAGCAAGGGTTCGACGCATGAATCAAACGGTTCTAATATCTGATCAACCATTAGATTTATCTACTAAAAAATCGAATGTATCAGTTACGTCAAGTCCTTCACCTTCGCCATCTTGCAGCATTTCAGTGACACATTCCGATTCTGAAGAAGCGGTAAATTTGAGCCAAAAATCGTCTCGTAGCACAACCCCGCAccatacacaatatttaaatacgtatccACATTCCAATTGTTCATCTTCGTCTATTACCGACTTTGGACTATCGCCCTCGCCCGGAGAGAATTTAAATGGTCACAAAAGGCCTTTACCTCAAAAAATACCTATTAATCCAATTTTACCTATGGACAAACTCTTACAATATAATGATCTTGCGAACGCTAGATCTCCTATTCTGAACAAACATATGCCGTCAGACACAAACTGGCAAGGGTCGAGCCCGTCATATGAACGAAATTCTTGGGGCGACGAACAACAAACTCCAAATGAATTCGATGATAAAACGTTAGTACTTAAGAAAAATAAGGCGAAGAAGAACGCTGAATTTAAAGAAAGTGAAGGACAATTTGTATGCGACCAATGCGACAAAACTTTCGTTAAACAAAGCTCATTAGCGCGACATAAATATGAGCACTCAGgtCAACGACCCTACAGATGTTTGGAGTGTCCGAGGGCTTTCAAGCATAAGCATCATCTGACCGAGCACAAGCGGCTCCATACCGGGGAAAAGCCTTTTCAATGCTGCAAGTGTCTCAAGAAGTTCTCCCACTCTGGCTCGTACAGTCAGCATATGAACCACAGGTTCGCTATTTGCAAACCGTACAGGGATTGA
Protein Sequence: MKVLGPLMGVGGWYERLAAGWLADMRSKQVPTSATSARRLAATIRPLTGGGSEGKPSEEEEDRGGSPLGPGGPFSCSQCRGAYPTREQLERHEKLHSPNTQVDRVKYTCKICHKSFINVYRLQRHMISHDESARLRKFKCNDCDKAFKFKHHLKEHLRIHSGEKPFECANCGKKFSHSGSYSSHMTSKKCLVMNLKMGRIKPNNPALNPDRSPSRKRSNAMVASQINNNITPNTSFLPTLPKYNTAAFFAWTPTPDNNFPQSTLPQPGLNPFYMPPGVPMSPTTGIAPYTIPASIGQFFAQLASSQYPLRKIEKPISPNQHGIPLGDPEDLIEEVTEEDDKRSEGSAELVMDIEDDAISVKKEQDDLEADPRSPQNFESVPMNDNDHEAGNNHAGFKTILETVSASVTKHFLRANMEKLSPVSGNVCPSIESSAAPHIVVKNKYVDTNQCLKCNATFSTIDELIKHDKSDCENMFRKHEGLAAQVAETVALNRLEAEIRASIQSGVSASEDEDFGRDDREDKTSLNDSDRKIRVRTALSEEQQVILKEHYTINPRPNREEFKKIAQQIGLDSRVVQVWFQNNRARVRRMNQTVLISDQPLDLSTKKSNVSVTSSPSPSPSCSISVTHSDSEEAVNLSQKSSRSTTPHHTQYLNTYPHSNCSSSSITDFGLSPSPGENLNGHKRPLPQKIPINPILPMDKLLQYNDLANARSPILNKHMPSDTNWQGSSPSYERNSWGDEQQTPNEFDDKTLVLKKNKAKKNAEFKESEGQFVCDQCDKTFVKQSSLARHKYEHSGQRPYRCLECPRAFKHKHHLTEHKRLHTGEKPFQCCKCLKKFSHSGSYSQHMNHRFAICKPYRD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00025472;
90% Identity: iTF_00971109;
80% Identity: iTF_00971109;