Mdor009186.1
Basic Information
- Insect
- Megastigmus dorsalis
- Gene Symbol
- run_1
- Assembly
- GCA_900490025.1
- Location
- UELU01126578.1:4030-7872[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 7.7e-72 6e-68 227.1 0.0 2 129 17 144 16 144 0.98
Sequence Information
- Coding Sequence
- ATGCATTTGCCGGAGGGTCCGATCGGCATGGACAACTTCAACGCGATCCACGAGACACTGCGCGCCTGTCACGGCGACCTCGTGCAGACCGGCAGTCCAGCTATACTCTGCAGTCCTCTGCCTACCCATTGGCGATCTAACAAGTCGCTGCCCGTGGCCTTCAAGGTCGTCACCTTGGACGAGGTCAGCGACGGGACCCTCGTCACCATCAGCGCGGGCAACGACGAGAACTTCTGCGGCGAGCTGAGAAACTGCACGGCCGTCATGAAGAACCAAGTTGCCAAGTTCAACGATCTCAGATTCGTTGGACGCAGCGGCAGAGGAAAGTCGTTCTCACTGACGATACAAATCAGTACGGTGCCTTTTCAAGTAGCCACATACACGAAAGCCATCAAGGTTACCGTAGACGGACCAAGGGAACCTCGATCAAAGTCGAATTACCAATACGGACCTGGATTTCCGGCACTGGGACTATTGAATCCGTGGCTGGACGCGGCCTACCTCGGTCACGCCTGGCACCTGCCCCATCCCGCGCTCGTCAAAGGATCAATCGGCATGCCGCATACCGATCTCTTCGGTCCGAGCTTCCCACCAACGGTCATACCCTCGGCATATCCATTCGCCGACCACGTCAACAAGTACAACACAGCGACGGCGCAACCGCAAACCGACTTCATCAGCAGCCTCTCGCACAAGAGCTCCTCGGTCCACTCGACGAcgccaccgacgacgacgacacccTTGGCCAGCAGCCTACTCCTGGCGAACAGTCCGTCGCGCACACCGCCGCGCAGTCCGAGCGACACGGGCAGCGAGTCGGCACCCGAGGAAGTGCGCAGTGCCTTCGTGCCGATCCGTCTCAATCCTATGGCCAGTTCGGTTACGCCCTCCTCCTCGTCACCCGAGCGACTCAATACGAGGAGGCCCTTGGAGGGCACGAGGAACGAGCTCAAGGCGCCCACGGCACTCATATCGCACAGGACCAGCGTGGACAAGAGGAGTCCGCCGCCCACCAAGATCCAGGCGCCGCCTGCGGCCAAACCAGTCTGGAGGCCCTACTAG
- Protein Sequence
- MHLPEGPIGMDNFNAIHETLRACHGDLVQTGSPAILCSPLPTHWRSNKSLPVAFKVVTLDEVSDGTLVTISAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTIQISTVPFQVATYTKAIKVTVDGPREPRSKSNYQYGPGFPALGLLNPWLDAAYLGHAWHLPHPALVKGSIGMPHTDLFGPSFPPTVIPSAYPFADHVNKYNTATAQPQTDFISSLSHKSSSVHSTTPPTTTTPLASSLLLANSPSRTPPRSPSDTGSESAPEEVRSAFVPIRLNPMASSVTPSSSSPERLNTRRPLEGTRNELKAPTALISHRTSVDKRSPPPTKIQAPPAAKPVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00969352; iTF_00738849; iTF_00304292; iTF_00845069; iTF_00708353; iTF_00309285; iTF_01523816; iTF_01218857; iTF_00707618; iTF_00463783; iTF_01035984; iTF_01036804; iTF_01035221; iTF_00286115; iTF_01486895; iTF_01274257; iTF_00286970; iTF_01216565; iTF_00304865; iTF_00305437;
- 90% Identity
- iTF_00969352;
- 80% Identity
- -